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71.
Yan Chen Ge Zou Wencong Yang Yingying Zhao Qi Tan Lin Chen Jinmei Wang Changyang Ma Wenyi Kang Zhigang She 《Marine drugs》2021,19(2)
One new diterpenoid, diaporpenoid A (1), two new sesquiterpenoids, diaporpenoids B–C (2,3) and three new α-pyrone derivatives, diaporpyrones A–C (4–6) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a comparison of the specific rotation. Compound 1 had an unusual 5/10/5-fused tricyclic ring system. Compounds 1 and 4 showed potent anti-inflammatory activities by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW264.7 cells with IC50 values of 21.5 and 12.5 μM, respectively. 相似文献
72.
Hee Jae Shin Gam Bang Pil Soo-Jin Heo Hyi-Seung Lee Jong Seok Lee Yeon-Ju Lee Jihoon Lee Ho Shik Won 《Marine drugs》2016,14(1)
Chemical investigation of a marine-derived fungus, Penicillium steckii 108YD142, resulted in the discovery of a new tanzawaic acid derivative, tanzawaic acid Q (1), together with four known analogues, tanzawaic acids A (2), C (3), D (4), and K (5). The structures of tanzawaic acid derivatives 1–5 were determined by the detailed analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis. These compounds significantly inhibited nitric oxide (NO) production and the new tanzawaic acid Q (1) inhibited the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins and mRNA expressions in RAW 264.7 macrophages. Additionally, compound 1 reduced the mRNA levels of inflammatory cytokines. Taken together, the results of this study demonstrated that the new tanzawaic acid derivative inhibits LPS-induced inflammation. This is the first report on the anti-inflammatory activity of tanzawaic acid Q (1). 相似文献
73.
Natalya N. Besednova Boris G. Andryukov Tatyana S. Zaporozhets Tatyana A. Kuznetsova Sergey P. Kryzhanovsky Svetlana P. Ermakova Irina V. Galkina Mikhail Yu. Shchelkanov 《Marine drugs》2022,20(4)
Inflammatory reactions are part of a complex biological response that plays a vital role in the appearance of various stimuli resulting from tissue and cell damage, the invasion of pathogenic bacteria, and the formation of the subsequent adaptive immune response. The production of many triggers and mediators of inflammation, which are inducers of pro-inflammatory factors, is controlled by numerous differentiation programs, through which inflammation is resolved and tissue homeostasis is restored. However, prolonged inflammatory responses or dysregulation of pro-inflammatory mechanisms can lead to chronic inflammation. Modern advances in biotechnology have made it possible to characterize the anti-inflammatory activity of phlorotannins, polyphenolic compounds from brown seaweed, and the mechanisms by which they modulate the inflammatory response. The purpose of this review is to analyze and summarize the results of numerous experimental in vitro and in vivo studies, illustrating the regulatory mechanisms of these compounds, which have a wide range of biological effects on the body. The results of these studies and the need for further research are discussed. 相似文献
74.
Chia-Chi Peng Tzu-Yin Huang Chiung-Yao Huang Tsong-Long Hwang Jyh-Horng Sheu 《Marine drugs》2021,19(5)
Two new isosarcophine derivatives, cherbonolides M (1) and N (2), were further isolated from a Formosan soft coral Sarcophyton cherbonnieri. The planar structure and relative configuration of both compounds were established by the detailed analysis of the IR, MS, and 1D and 2D NMR data. Further, the absolute configuration of both compounds was determined by the comparison of CD spectra with that of isosarcophine (3). Notably, cherbonolide N (2) possesses the unique cembranoidal scaffold of tetrahydrooxepane with the 12,17-ether linkage fusing with a γ-lactone. In addition, the assay for cytotoxicity of both new compounds revealed that they showed to be noncytotoxic toward the proliferation of A549, DLD-1, and HuCCT-1 cell lines. Moreover, the anti-inflammatory activities of both metabolites were carried out by measuring the N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced generation of superoxide anion and elastase release in the primary human neutrophils. Cherbonolide N (2) was found to reduce the generation of superoxide anion (20.6 ± 6.8%) and the elastase release (30.1 ± 3.3%) in the fMLF/CB-induced human neutrophils at a concentration of 30 μM. 相似文献
75.
76.
Yen-You Lin Sung-Chun Lin Chien-Wei Feng Pei-Chin Chen Yin-Di Su Chi-Min Li San-Nan Yang Yen-Hsuan Jean Ping-Jyun Sung Chang-Yih Duh Zhi-Hong Wen 《Marine drugs》2015,13(5):2559-2579
In recent years, several marine-derived compounds have been clinically evaluated. Diterpenes are secondary metabolites from soft coral that exhibit anti-inflammatory, anti-tumor and cytotoxic activities. In the present study, we isolated a natural diterpene product, excavatolide B, from cultured Formosan gorgonian Briareum excavatum and investigated its anti-inflammatory activities. We found that excavatolide B significantly inhibited the mRNA expression of the proinflammatory mediators, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in lipopolysaccharide (LPS)-challenged murine macrophages (RAW 264.7). We also examined the anti-inflammatory and anti-nociceptive effects of excavatolide B on intraplantar carrageenan-induced inflammatory responses. Excavatolide B was found to significantly attenuate carrageenan-induced nociceptive behaviors, mechanical allodynia, thermal hyperalgesia, weight bearing deficits and paw edema. In addition, excavatolide B inhibited iNOS, as well as the infiltration of immune cells in carrageenan-induced inflammatory paw tissue. 相似文献
77.
《Journal Of Aquatic Food Product Technology》2012,21(10):1092-1104
ABSTRACTSeaweeds are consumed as staple food items in the cuisines of many Asian countries and are considered as essential components of a healthy diet. The pharmacological potential of ethyl acetate-methanol (EtOAc-MeOH) extract of 10 species of seaweeds belonging to the subclasses Dictyotophycidae, Rhodymeniophycidae, and Corallinophycidae against progressive lifestyle diseases was determined by various in vitro models. Among the studied species, the organic extracts of Gracilaria salicornia and Padina tetrastromatica exhibited potential dipeptidyl-peptidase-4 inhibiting activity (IC50 ~ 0.03 mg mL−1) and angiotensin converting enzyme-I inhibitory property (ACE-I) (IC50 0.12 mg mL−1) compared to those displayed by other studied species. The organic extracts of G. salicornia and P. tetrastromatica also displayed significantly greater attenuation properties against pro-inflammatory cyclooxygenase-2 and 5-lipoxygenase (IC50 0.98–1.34 mg mL−1, P < .05) compared to those derived from other species (IC50 1.99–5.02 mg mL−1). The nuclear magnetic resonance-guided dereplication of organic extracts of the studied seaweed species recognized the co-linearity between the bioactive potential and downfield electronegative functionalities. These results recognized the significance of the organic extracts of G. salicornia and P. tetrastromatica to isolate compounds for functional food applications against oxidative stress and induced diseases, such as diabetes, hypertension, and inflammation. 相似文献
78.
[目的]为了探明阿魏酸的抗炎机制.[方法]采用组织块培养法获得奶牛子宫内膜上皮细胞.用噻唑蓝(MTT法)检测细胞活力.采用荧光定量PCR方法,分别对对照组、模型组、药物作用高、中、低剂量组在LPS作用3h、6h炎症基因IL-1β、IL-6、IL-8和TNF-α的mRNA变化进行检测.[结果]阿魏酸在一定浓度范围内对细胞增殖无显著影响.药物预处理细胞能够显著降低LPS诱导的IL-1β、IL-6、IL-8和TNF-α的mRNA表达.[结论]阿魏酸能够显著降低LPS刺激细胞后炎症细胞因子的表达,说明阿魏酸是通过抑制炎症因子的表达发挥其抗炎作用. 相似文献
79.
80.
五谷虫粗提物的抗炎效果及对小鼠免疫调节的影响 总被引：1，自引：0，他引：1
为探讨五谷虫粗提物对急性炎症的抑制效果以及对机体免疫机能的影响,利用耳肿胀法判断五谷虫粗提物对小鼠的抗炎效果,通过免疫器官指数、血清部分生化指标、血清溶血素含量及碳廓清指数的测定来考察五谷虫粗提物对小鼠免疫功能的影响。结果表明：五谷虫粗提物能够明显降低小鼠的耳肿胀程度,显著提高小鼠脾和胸腺指数,能够提高血清中球蛋白的含量,同样能够显著提高小鼠半数溶血值及吞噬指数。由此可以推断,五谷虫粗提物有抗炎作用,且能够提高小鼠的免疫功能。 相似文献