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51.
52.
Canine oral melanoma   总被引:2,自引:0,他引:2  
Melanoma is the most common oral malignancy in the dog. Oral and/or mucosal melanoma has been routinely considered an extremely malignant tumor with a high degree of local invasiveness and high metastatic propensity. Primary tumor size has been found to be extremely prognostic. The World Health Organization staging scheme for dogs with oral melanoma is based on size, with stage I = <2-cm-diameter tumor, stage II = 2- to <4-cm-diameter tumor, stage III = > or = 4cm tumor and/or lymph node metastasis, and stage IV = distant metastasis. Median survival times for dogs with oral melanoma treated with surgery are approximately 17 to 18, 5 to 6, and 3 months with stage I, II, and III disease, respectively. Significant negative prognostic factors include stage, size, evidence of metastasis, and a variety of histologic criteria. Standardized treatments such as surgery, coarse-fractionation radiation therapy, and chemotherapy have afforded minimal to modest stage-dependent clinical benefits and death is usually due to systemic metastasis. Numerous immunotherapeutic strategies have been employed to date with limited clinical efficacy; however, the use of xenogeneic DNA vaccines may represent a leap forward in clinical efficacy. Oral melanoma is a spontaneous syngeneic cancer occurring in outbred, immunocompetent dogs and appears to be a more clinically faithful therapeutic model for human melanoma; further use of canine melanoma as a therapeutic model for human melanoma is strongly encouraged. In addition, the development of an expanded but clinically relevant staging system incorporating the aforementioned prognostic factors is also strongly encouraged.  相似文献   
53.
建立了苦参苍术口服液中三氯甲烷残留量的气相色谱检测方法,采用DB—FFAP毛细管柱,柱温为程序升温,氢火焰离子化检测器(FID),检测器温度为250℃,进样口温度为220oC,载气为氮气。试验结果三氯甲烷在6.0464~120.928μg/mL浓度范围内呈良好的线性关系(r=0.99995),加样回收实验平均回收率为98.01%(RSD=1.6%)。本方法简便、快速、准确、重现性好,可作为苦参苍术口服液中三氯甲烷残留量的检测方法。  相似文献   
54.
The bioavailability of three formulations of ivermectin was determined following oral administration to dogs. The average peak plasma level (C max) of ivermectin administered in the standard tablet formulation at 6 and 100 µg/kg of body weight was 2.97 and 44.31 ng/g, respectively. This suggest dose-dependent pharmacokinetics.C max and total ivermectin bioavailability, as assessed from the area under the plasma curve (AUC), were similar between two tablet formulations of ivermectin administered at 100 µg/kg. Furthermore,C max was similar following administration of radiolabelled ivermectin at 6 µg/kg in either a beef-based chewable formulation or in the standard tablet formulation.  相似文献   
55.
Two horses, presented for investigation of chronic weight loss despite normal to increased feed intake, had flat oral glucose absorption curves, suggesting malabsorption. The cause of the apparent malabsorption was not evident grossly or on light microscopic examination of the intestinal tract. Both horses survived long term and at follow-up examination had regained weight and their capacity to absorb glucose. These cases illustrate that flat glucose absorption curves may occur in horses with no obvious intestinal lesions, that they may revert to normal and that the results of these tests should be interpreted with caution.  相似文献   
56.
Feline chronic gingivitis/stomatitis (FCGS) is a painful inflammatory disease in cats. Extraction of teeth, including all premolars and molars, has been shown to be the therapy of choice in cats not responding sufficiently to home care (e.g. tooth brushing) and/or medical treatment (corticosteroids and/or antibiotics). In this study, we hypothesize that a cat food with an omega‐6 polyunsaturated fatty acid (ω6 PUFA) to ω3 PUFA ratio of 10:1 reduces inflammation of the FCGS and accelerates soft tissue wound healing of the gingiva after dental extractions, compared to a cat food with a ω6:ω3 PUFA ratio of 40:1. The cats were fed diets with chicken fat and fish oil as sources of fatty acids. In one diet, part of the fish oil was replaced by safflower oil, resulting in two diets with ω6:ω3 PUFA ratios of 10:1 and 40:1. This double‐blinded study in two groups of seven cats revealed that dietary fatty acids influence the composition of plasma cholesteryl esters and plasma levels of inflammatory cytokines. The diet with the 10:1 ratio lowered PGD2, PGE2 and LTB4 plasma levels significantly, compared to the diet with the 40:1 ratio (p = 0.05, p = 0.04, and p = 0.02 respectively). However, feeding diets with dietary ω6:ω3 PUFA ratios of 10:1 and 40:1, given to cats with FCGS for 4 weeks after extraction of all premolars and molars, did not alter the degree of inflammation or wound healing.  相似文献   
57.
为了探究新疆一枝蒿口服液的最佳制备工艺,采用水提醇沉法提取新疆一枝蒿中的总黄酮,经单因素、响应面试验获取最佳的制备工艺参数,并通过薄层层析与含量限度测定对新疆一枝蒿口服液建立初步的质量控制。结果表明:新疆一枝蒿最佳制备工艺为料液比1:14,煎煮时间为1.5 h,醇沉浓度为50%。供试品色谱中,在与对照品色谱相应的位置上,显相同颜色的斑点,含量限度测定黄酮含量范围在28.67~29.59 mg/mL,平均值为29.10 mg/mL,最低限度为23.28 mg/mL。  相似文献   
58.
从语音和词汇两个层面探讨了将文体学理论应用于英语专业低年级口语教学的必要性和可行性,提出培养学生的文体意识在提高学生口头交际能力上具有重要的作用。  相似文献   
59.
随着国际间的频繁交往以及中国政治经济地位的不断提升,对具备英语口语表达能力的人才也提出了更高的要求,大学毕业生应能和外国人进行英语交流、用英语完成求职面试、出国旅游等.因此,提高大学生英语口语水平尤为重要,教育者应尝试新的教学模式,用一种新的理论来指导大学英语口语教学,本文从系统功能语法这个纯理论角度探讨了如何以一种新的模式来提高口语能力.  相似文献   
60.
在构建L.lactis表达载体pNZ8148-fae G的基础上,将该载体转化到L.lactis NZ9000中,重组菌经5 μg/Lnisin诱导3 h,SDS-PAGE结果显示,FaeG在L.lactis中表达的目的蛋白相对分子质量大小约为27 000,表达产物的量达菌体可溶性总蛋白的10.89%.Western blot分析结果表明,该目的蛋白具有良好反应原性.将重组L.lactis口服免疫BALB/c小鼠,小鼠产生特异性IgG及黏膜slgA.本试验为进一步研究仔猪口服重组L.lactis疫苗,诱导其产生抗ETEC K88黏膜免疫的同时,发挥L.lactis的益生功能,预防仔猪腹泻奠定了基础.  相似文献   
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