The construction and application of a population physiologically based pharmacokinetic model for methadone in Beagles and Greyhounds

Methadone is an opioid analgesic in veterinary and human medicine. To help develop appropriate pain management practices and to develop a quantitative model for predicting methadone dosimetry, a flow‐limited multiroute physiologically based pharmacokinetic (PBPK) model for methadone in dogs constructed with Berkeley Madonna? was developed. The model accounts for intravenous (IV), subcutaneous (SC), and oral administrations, and compartmentalizes the body into different components. This model was calibrated from plasma pharmacokinetic data after IV administration of methadone in Beagles and Greyhounds. The calibrated model was evaluated with independent data in both breeds of dogs. One advantage of this model is that most physiological parameter values for Greyhounds were taken directly from the original literature. The developed model simulates available pharmacokinetic data for plasma concentrations well for both breeds. After conducting regression analysis, all simulated datasets produced an R ² > 0.80 when compared to the measured plasma concentrations. Comparative analysis of the dosimetry of methadone between the breeds suggested that Greyhounds had ~50% lower 24‐hr area under the curve (AUC) of plasma or brain concentrations than in Beagles. Furthermore, population analysis was conducted with this study. This model can be used to predict methadone concentrations in multiple dog breeds using breed‐specific parameters.     

基于纵向传导的蔬菜批零价格关系研究——以北京市果类蔬菜为例

从蔬菜产业的纵向看,批发和零售是两个重要环节,蔬菜批发价格和零售价格的走势以及它们之间的关系是各界关注的焦点。本文以北京市场为例,以番茄和黄瓜两种果类蔬菜的按日批零价格为对象,运用有限分布滞后模型和误差修正模型进行实证分析,研究蔬菜批零价格间的传导关系,并在此基础上揭示蔬菜批发价格在蔬菜价格形成中的作用。研究发现:蔬菜批零价格走势基本一致,相关系数很高;批零价格间存在批发价格向零售价格单向传导的因果关系;批零价格的传导是顺畅的,但不同种蔬菜传导的时间效应有所不同;批发价格在蔬菜价格形成中占据主导作用,当蔬菜价格受到冲击时,若零售价格过高则其会向着批发价格下调,若批发价格过高则零售价格会随之走高。     

高校心理健康教育网络课程模式的构建与实例分析

计算机多媒体技术和网络技术日新月异的发展,教育信息化的推进,为努力实现高校心理健康教育课程教学内容、教学手段和教学方法的全面创新,本文以《心理健康教育》网络课程为例,尝试剖析其在模式构建、教学设计、交互安排、教学应用等方面的特征,以期为开辟高校心理健康教育课程的新模式提供思路。     

小兴安岭天然林不同树种的树高曲线模型

选用10种树高曲线模型作为候选模型,以决定系数(R~2)、残差平方和(S_(se))和均方差(M_(se))作为模型优劣的评价指标,对小兴安岭天然林中的云杉(Picea asperata)、红松(Pinus koraiensis)、水曲柳(Fraxinus mandschurica)、椴树(Tilia tuan)4种树种的树高曲线模型进行优选。结果表明:云杉、红松和椴树的最优模型均为Logistic模型,水曲柳的最优模型为抛物线模型;云杉和红松两种针叶树种,最优模型的优势不明显,水曲柳和椴树两种阔叶树种最优模型的优势较明显;比较R~2的大小,得出较适合小兴安岭云杉和红松两种针叶树种的树高曲线模型(R~20.8),对小兴安岭阔叶树种的适用程度不具有普遍性,对椴树的适用性好(R~2最大达0.94),对水曲柳的适用性较差(R~20.8)。对水曲柳的树高进行分段研究得出:水曲柳在树高低于9 m时,树高曲线模型较适宜(R~20.8),其中抛物线模型为最优模型;树高较高时,没有适用的树高曲线模型。     

基于EEF模型的昆明市生态系统发展状态评价

运用能值分析理论改进的生态足迹模型(EEF),对昆明市2002~2011年能值足迹的动态变化进行分析,并应用GM(1,1)模型,对未来10年人均能值进行预测。结果发现:EEF模型的计算数值明显高于传统模型;昆明市生态系统出现盈余,处于可持续发展状态;在自然环境、经济状况不发生"突变"的前提下,2012~2020年人均能值盈余呈下降趋势且年均递减率为20.57%,尽管生态系统没有赤字,但生态安全面临严峻挑战。本研究对"新昆明"建设及其生态系统的可持续发展将有着重要的启示。     

Long-term fertilization effects on active ammonia oxidizers in an acidic upland soil in China

The effects of long-term fertilization of acidic soils on ammonia-oxidizing archaea (AOA) and bacteria (AOB) communities and its ecological implications remain poorly understood. We chose an acidic upland soil site under long-term (27-year) fertilization to investigate ammonia oxidizer communities under four different regimes: mineral N fertilizer (N), mineral NPK fertilizer (NPK), organic manure (OM) and an unfertilized control (CK). Soil net nitrification rates were significantly higher in OM soils than in CK, N or NPK soils. Quantitative analysis of the distribution of amoA genes by DNA-based stable isotope probing revealed that AOA dominate in CK, N and NPK soils, while AOB dominate in OM soils. Denaturing gradient gel electrophoresis and clone library analyses of amoA genes revealed that Group 1.1a-associated AOA (also referred to as Nitrosotalea) were the most dominant active AOA population (>92%), while Nitrosospira Cluster 3 and Cluster 9 were predominant among active AOB communities. The functional diversity of active ammonia oxidizers in acidic soils is affected by long-term fertilization practices, and the responses of active ammonia oxidizers to mineral fertilizer and organic manure are clearly different. Our results provide strong evidence that AOA are more highly adapted to growth at low pH and low substrate availability than AOB, and they suggest that the niche differentiation and metabolic diversity of ammonia oxidizers in acidic soils are more complex than previously thought.     

优化施肥对春小麦产量、氮素利用及氮平衡的影响

2009 ～ 2010年,在宁夏引黄灌区分别以宁春11号和宁春16号小麦为供试作物,利用田间试验研究了优化施肥(OPT)和习惯施肥(CON)对春小麦产量、氮素吸收利用和土壤硝态氮累积的影响,表观评估了土壤—小麦体系氮素平衡.结果表明,相对于CK处理,OPT和CON都显著提高春小麦籽粒产量地上部生物量,并促进籽粒N和地上...     

线性红利界下带干扰风险模型的破产概率

考虑到保险公司在实际经营中收益所具有的不确定性和分红策略，建立一类具有线性红利界和带随机扰动的双复合Poisson风险模型，利用鞅方法给出模型关于破产概率的一个定理及上界．     

秃杉人工林施肥效应试验初报

采用不同肥料种类和施肥剂量对秃杉人工林进行施肥对比试验。观测胸径、树高和蓄积生长量,分析不同肥料种类和施肥剂量对秃杉人工幼龄林高、粗和蓄积生长量的效应。试验结果表明,合理的施肥措施对秃杉人工林生长有明显促进作用,与对照相比,年高生长增加34%,粗生长增加26%,蓄积生长增加35%。     

“互联网+农业”模式下食用菌的营销策略

在"互联网+农业"融合发展背景下,食用菌企业需要借助互联网,构建市场主导、数字驱动的全新营销战略,助力产品营销。以"互联网+农业"模式为研究视角,分析食用菌产品营销现状,提出发挥技术优势、挖掘用户需求和建设优质平台等营销建议,以助力食用菌产品市场营销与效益转化。