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111.
M Fevrier 《Comparative immunology, microbiology and infectious diseases》1985,8(2):159-170
Antibody response to an antigen involves the co-operation between three types of cells: macrophages, T cells and B cells. The cognate interactions between these cells play a fundamental role in the expression of a specific antibody response, but the last is modulated by antigen-nonspecific soluble factors produced either by macrophages or by T cells. Macrophages elaborate a spectrum of molecules modulating the function of lymphoid cells; among them are IL1 and prostaglandins of the E series, which are respectively enhancer and inhibitor of the antibody response in vitro. These molecules alter T cell and B cell activities through different mechanisms involving activation or inhibition of IL2 production, or alteration of cells surface antigens. However, the cellular events following the fixation of soluble factor on its receptors are not known. 相似文献
112.
The purpose of the study was to correlate electroretinogram (ERG) parameters with increasing levels of plasma, erythrocyte and ocular tissue cholinesterase inhibition using the beagle dog as a model for human neurovisual toxicity. The anticholinesterase compound physostigmine was administered at various steady-state intravenous infusion rates based on pharmacokinetic estimates of plasma and red blood cell cholinesterase inhibition. The most sensitive parameter was the b-wave amplitude of the rod response, which was significantly depressed compared to pretreatment at all levels of acute cholinesterase depression. The overall maximal ERG response demonstrated a trend of declining a-and b-wave amplitudes, which corresponded with the increased levels of cholinesterase depression, but these differences were not significant. The depression of the electroretinogram rod and cone amplitudes appeared to parallel plasma cholinesterase inhibition more closely than erythrocyte cholinesterase activity. Ocular tissue cholinesterase activity was significantly depressed in the retina (70%), cornea (60%) and dorsal rectus extraocular muscle (46%). Electroretinography may be a useful physiological tool for evaluating the ocular toxicity of certain chemicals or pharmaceuticals associated with cholinesterase biomarker activity.Abbreviations AChE
acetylcholinesterase
- Amp
amplitude
- BuChE
butyrylcholinesterase
-
C
p
plasma level
-
C
ss
steady-state plasma concentration
-
D
L
loading dose
- e
–kt
the rate of elimination over time (t)
- ERG
electroretinogram
-
k
elimination rate constant
- Lat
latency
- MBW
metabolic body weight
- O1–O5
consecutive oscillatory potential wavelets
- PreTx
pretreatment
-
R
rate of infusion
-
R
Inf
rate of infusion
-
V
d
volume of distribution 相似文献
113.
114.
研究了盐酸介质中 ,在氯化纳的催化作用下 ,溴酸根离子氧化甲基红褪色的最佳条件 .吸收波长为 5 18nm .表观摩尔吸光系数为 7.2×10 4 L· m ol- 1 · cm- 1 ,溴酸根离子在 3.0~ 18μg/2 5 m L范围内符合比尔定律 .方法用于化学试剂中微量溴酸根的测定 ,结果令人满意 . 相似文献
115.
本研究是在呼和浩特市的自然条件下,对紫羊茅种子产量在不同播种量和不同行距情况下进行了试验。结果表明,紫羊茅的最适播量7.50kg/hm2,行距为30cm,在此播种体系中种子产量平均可达662.5kg/hm2。 相似文献
116.
117.
采用顶空固相微萃取气质联用(SPME–GC–MS)的方法检测红银花与金银花新鲜花蕾和
干花蕾的挥发性成分。4 种花蕾样品共鉴定出67 种挥发性物质,其中新鲜红银花与金银花分别检测出48
种和46 种,经烘干处理的干红银花与金银花分别检测出34 种和37 种。[3.2.1.0(1,5)]三环辛烷、β–
芳樟醇、5–甲基–2–己醇和以及十六烷是4 种样品共有的成分。其中红银花挥发性成分主要以烃类、
醇酮类为主,β–芳樟醇含量显著高于金银花;样品在由新鲜到烘干这一过程中,烃类和酯类挥发性物质
含量降低,醛类和醇酮类挥发性物质显著增加。 相似文献
118.
棉花高光谱及其红边特征(I) 总被引:3,自引:0,他引:3
通过大田和室内试验,测定了2个品种的棉花冠层、完全展开倒1、3叶在不同时期的高光谱反射率及对应叶片的叶绿素、类胡萝卜素含量。结果表明:随发育期推移,棉花冠层光谱反射率在可见光范围降低,在近红外区域增高;叶片背面光谱反射率略高于正面,透射率小于反射率;叶面积指数、鲜叶重和干叶重与冠层反射光谱变量ρ800 ρ550、ρ800 ρ680、ρ680 ρ570之间存在显著相关;叶片叶绿素和类胡萝卜素浓度与其反射光谱变量ρ680 ρ570、ρ673 ρ640、ρ680 ρ550、PSSRa、PSNDa、RCh之间也呈显著相关。 相似文献
119.
120.
Eighteen clones involving Erianthus, as one of the parents, were evaluated in a randomised block design under sub-tropical conditions of Karnal (Haryana, India).
Fifteen characters, which contribute towards stalk yield and juice-quality, were studied. The growth of these clones was monitored
during peak winter months of December and January. Significant variability existed among the clones for all the traits studied,
except for pol % in juice at 10-month crop age, indicating potentiality of the clones to select desirable types. Nine clones
showed significant increase in stalk length during winter months over the better standard Co 1148. Whereas 6 clones developed
more number of leaves than Co 1148. Both these characters showed high genetic variability, high heritability and hence, high
expected genetic gain. Path analysis revealed that these traits contributed about 16%, 5% and 4% to the total genetic variability
in juice quality traits (pol % and CCS %), stalk yield and CCS yield, respectively. Growth in winter months has resulted in
an increase in stalk yield and CCS yield. This may help in reducing the yield gap between tropical and sub-tropical regions.
Majority of clones showed resistance to red rot disease (major disease of sugarcane in sub-tropical region). Hence, hybridization
of Erianthus with sugarcane has resulted in introgression of genes for cold tolerance and red rot resistance. As Erianthus is known for its hardiness, resistance, of these clones, to other abiotic and biotic stresses is to be ascertained.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献