梯级引水工程水位优化调度模型研究

大型引水工程整个系统在进入稳态运行后,在各站的抽水流量或首级站进口水位发生变化的情况下及时做出运行决策,调整各梯级站间的水位,达到整个系统总能耗最小的目的。针对这一问题提出了大型引水工程各梯级站水位优化调度的数学模型,并对其解法进行探讨。     

灌溉渠系运行计算机模拟技术的开发

借鉴日本以及其他国家在灌溉渠系水管理方面的成果和经验，结合我国灌区的实际情况，建立了较完整的渠系运行模型，编制了具有一定通用性和可扩充性的计算机模拟软件。实践表明，该软件对于测试和评价渠系的力学特性、工程控制特性和管理调度特性是有效的，它为改进灌区水管理提供了一个科学、简便、可行的技术手段。     

梯级泵站供水系统水资源优化调度模型研究

采用系统分析理论 ,研究了梯级泵站供水系统的水资源优化调度问题 ,建立了具有提调水量和泄弃水量两个决策变量及多级泵站、多个水库、多个供水片的多目标水资源优化调度模型 ,给出了自优化模拟调度方法。经实例研究表明 ,模型是可行和实用的     

采棉机跨区作业导航电子地图的制作

为了使采棉机跨区作业管理中的监控定位更为准确,采用Alos和TM遥感影像、商用电子地图为基本材料,通过对Alos影像进行矢量化并结合外业调查得到作业区域的交通、田块、POI等空间信息图层。同时对TM遥感影像进行监督分类,识别出棉花地块以及面积等信息,在MapInfo桌面GIS软件中对其进行整合得到作业区地图,再与商用电子地图进行图层叠加处理,最后制得高精度、要素丰富、适用于采棉机作业过程中导航定位的电子地图。该采棉机跨区作业导航电子地图使采棉机跨区作业过程中的监控定位更加准确,管理更加有效,既能适应大区域的调度,也能做小范围的作业定位和监控。因此,该采棉机跨区作业导航电子地图的制作方法为制作农业生产应用电子地图提供了技术手段。     

Screening of Human CYP1A2 and CYP3A4 Inhibitors from Seaweed In Silico and In Vitro

Phenolic compounds and carotenoids are potential inhibitors of cytochrome P450s. Sixteen known compounds, phenolic compounds and carotenoids from seaweed were examined for potential inhibitory capacity against CYP1A2 and CYP3A4 in silico and in vitro. Morin, quercetin, and fucoxanthin inhibited the enzyme activity of CYP1A2 and CYP3A4 in a dose-dependent manner. The IC₅₀ values of morin, quercetin, and fucoxanthin were 41.8, 22.5, and 30.3 μM for CYP1A2 and 86.6, 16.1, and 24.4 μM for CYP3A4, respectively. Siphonaxanthin and hesperidin did not show any significant effect on CYP1A2, but they slightly inhibited CYP3A4 activity at high concentrations. In silico modeling of CYP’s binding site revealed that the potential inhibitors bound in the cavity located above the distal surface of the heme prosthetic group through the 2a or 2f channel of CYPs. This study presents an approach for quickly predicting CYP inhibitory activity and shows the potential interactions of compounds and CYPs through in silico modeling.     

The Evaluating Model of the BSC in the Audit of the Capacity of Sustainable Operation

With the increasingly economic competition in the World, the audit industry, numerous investors and the enterprises pay more and more attention on the audit of company's sustainable operation. In view of existing situation that the audit on the capacity of sustainable operation attach main importance to the finance of the audited company, in the result, it is difficult to recognize it completely. The model of the balanced scorecard is used, an indicator system that combine company's finance condition and non-finance condition is built in the sustainable operation audit. Basing on the way to process non-dimensional quantities of indicators, the audit use the analytic hierarchy process to determine the weights of the evaluating indicators and take the degree of gray incidence as the evaluation criteria.     

农民家庭经营性收入分配变动实证研究——基于浙江省农村金融发展的视角

长期以来,农村居民内部收入差距始终呈现一种不断扩大的趋势,但基于收入来源分解所得的农民家庭经营性收入差距,却在维持了很长一段时间的相对稳定态势之后,才出现快速上升的现象,其背后的深层次原因是什么?该文从农村金融发展的角度加以解释,认为长期以来的农村金融抑制限制了农户家庭经营性收入差距的扩大,而不断深化的农村金融体制改革打破了传统的家庭经营模式,从而拉大了农户间的收入差距。随后,以浙江省为例进行实证检验,结果支持上述论断,并发现浙江省农村金融发展短期内开始扩大农民家庭经营性收入差距,但长期来看两者存在倒U型关系。农村金融持续发展将有助于改善农村收入分配关系。     

毛细管电泳及其在药物分析中的应用

阐述了不同操作模式毛细管电泳的分离机制，介绍了其在药物分析中的应用。     

模块式苗木抚育机辅助作业臂模块动力学分析

应用Solid Works软件及ADAMS仿真软件,对模块式苗木抚育机辅助作业臂模块进行了虚拟样机建立与动力学仿真。结果表明:应用软件建立三维模型以及动力学仿真,验证了抚育机辅助作业臂模块翻转、升降、恢复的动作过程,说明虚拟样机运行良好。借助ADAMS软件,对正载及偏载工况下辅助作业臂模块进行了动力学仿真,分别得到了辅助作业臂模块在不同工况下翻转油缸以及升降油缸受力曲线和关键铰点的受力曲线,辅助作业臂模块受力变化情况吻合辅助作业臂模块实际受力情况。应用虚拟样机技术,对抚育机辅助作业臂进行动力学仿真,有着过程高效、低成本、输出结果直观形象、仿真效果好等特点。     

A combined application of molecular docking technology and indirect ELISA for the serodiagnosis of bovine tuberculosis

BackgroundThere is an urgent need to find reliable and rapid bovine tuberculosis (bTB) diagnostics in response to the rising prevalence of bTB worldwide. Toll-like receptor 2 (TLR2) recognizes components of bTB and initiates antigen-presenting cells to mediate humoral immunity. Evaluating the affinity of antigens with TLR2 can form the basis of a new method for the diagnosis of bTB based on humoral immunity.ObjectivesTo develop a reliable and rapid strategy to improve diagnostic tools for bTB.MethodsIn this study, we expressed and purified the sixteen bTB-specific recombinant proteins in Escherichia coli. The two antigenic proteins, MPT70 and MPT83, which were most valuable for serological diagnosis of bTB were screened. Molecular docking technology was used to analyze the affinity of MPT70, MPT83, dominant epitope peptide of MPT70 (M1), and dominant epitope peptide MPT83 (M2) with TLR2, combined with the detection results of enzyme-linked immunosorbent assay to evaluate the molecular docking effect.ResultsThe results showed that interaction surface Cα-atom root mean square deviation of proteins (M1, M2, MPT70, MPT83)-TLR2 protein are less than 2.5 A, showing a high affinity. It is verified by clinical serum samples that MPT70, MPT83, MPT70-MPT83 showed good diagnostic potential for the detection of anti-bTB IgG and M1, M2 can replace the whole protein as the detection antigen.ConclusionsMolecular docking to evaluate the affinity of bTB protein and TLR2 combined with ELISA provides new insights for the diagnosis of bTB.