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21.
Michael R. Metcalf DVM MS Lloyd P. Tate DVM Loouis C. Sellett MS 《Veterinary radiology & ultrasound》1989,30(2):80-87
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过氧化物酶体增殖剂受体与脂质代谢调控 总被引:5,自引:0,他引:5
综述了过氧化物酶体增殖剂受体在动物体内的分布、结构与转录调节机制及其对脂肪细胞分化、脂质代谢的调控。 相似文献
23.
Randomized placebo-controlled crossover studies were carried out in dogs to evaluate how two non-steroidal anti-inflammatory drugs (NSAID) might modulate an acute post-traumatic inflammatory reaction. Two "identical" surgical interventions were performed on the forelimbs of each animal with an interval of 28 days, to enable a paired comparison of the inflammatory signs and the wound/bone healing processes. At one operation 8 dogs received 300 mg phenylbutazone twice daily for 8 days starting on the day before surgery, and at the other operation matching placebo tablets were given. In a similar placebo-controlled trial another group of 8 dogs received 5 mg indomethacin twice daily. With phenylbutazone the post-operative swelling was not significantly reduced compared to placebo, but there was less pain and limping. With indomethacin the swelling was somewhat reduced, but there was no consistent difference to placebo in the pain and limping assessments. None of the drugs appeared to distinctly effect the wound or fracture healing, as evaluated by clinical inspection, comparison of radiographs and comparison of bone sections from the sites of surgery. It proved difficult to select an appropriate dosage of indomethacin due to its high potential to induce GI ulceration and bleeding in dogs. In this experimental surgical model with an acute inflammation, neither phenylbutazone nor indomethacin showed impressive anti-inflammatory or analgesic properties. In the same model paracetamol has proved to significantly and more efficiently, reduce both swelling and pain without any noticeable adverse effects, and appears to be a better alternative than the two presently tested NSAID. 相似文献
24.
The use of cultured hepatocytes from goats and cattle to investigate xenobiotic oxidative metabolism
C. Montesissa P. Anfossi G. Van't Klooster M. Mengelers 《Veterinary research communications》1996,20(5):449-460
The oxidative metabolism of aldicarb (ALD), a carbamate pesticide, and fenbendazole (FBZ), an anthelmintic, was studied using cultured hepatocytes obtained from 4 goats and a bullock and incubated with ALD (50 mol/L) and FBZ (10 mol/L). The parent compounds and the metabolites were measured by HPLC. Both compounds are metabolized at the sulphur atom via two sequential oxidations, first to the sulphoxide (aldicarb sulphoxide and oxfendazole, respectively) and then to the sulphone. Oxfendazole and fenbendazole sulphone from FBZ, and aldicarb sulphoxide from ALD were found in both species. Aldicarb sulphone was not produced by the hepatocyte preparations from the bullock. The good correlation obtained comparing the in vitro results of FBZ metabolism with published in vivo dat obtained on FBZ kinetics in the same species confirmed the usefulness of in vitro models for predictive analysis of in vivo xenobiotic biotransformations.Abbreviations ALD
aldicarb
- ALDSON
aldicarb sulphone
- ALDSOX
aldicarb sulphoxide
- BSA
bovine serum albumin
- ID
internal diameter
- EGTA
ethylene glycol bis(-aminoethyl ether) N,N,N,N-tetraacetic acid
- FBZ
fenbendazole
- FBZSON
fenbendazole sulphone
- HBSS
Hanks' balanced saline solution
- HPLC
high-pressure liquid chromatography
- LDH
lactate dehydrogenase
- MFO
mixed function oxidase
- NCS
newborn calf serum
- OXF
oxfendazole
- WME
Williams' Medium E 相似文献
25.
C. Jacyn Baker Daniel P. Roberts Norton M. Mock Bruce D. Whitaker Kenneth L. Deahl Andrey A. Averyanov 《Physiological and Molecular Plant Pathology》2005,67(6):1322
The plant apoplast is an important mediator of communication between the cell cytoplasm and its surroundings. Plant cell suspensions offer a convenient model system to gain insight into apoplastic physiology. Here, we describe a novel phenomenon that took place when two naturally occurring phenolics were added together to either soybean or tobacco cell suspensions. Acetosyringone (AS) and/or hydroxyacetophenone (HAP), phenolics found in the extracellular/apoplast of tobacco cells, were added to soybean or tobacco cell suspensions undergoing an oxidative burst. Individually, AS appeared to be utilized as a typical peroxidase substrate to scavenge hydrogen peroxide, while HAP was utilized at a much lower rate. However, when added together the rate of utilization of both phenolics increased and surprisingly resulted in the production of hydrogen peroxide. We have further characterized this novel phenomenon in suspension cells. This study demonstrates that certain phenolics in plants can cause co-oxidation which, as in animals, could alter the structure and bioactivity of surrounding phenolics. 相似文献
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选择3周龄健康、无病、体重无显著差异的肉仔鸡96只,随机分为3组,每组设4 个重复,每个重复8只。分别饲喂蛋白质水平(19.5%)相同而能量水平不同(3.0 Mcal/kg、 3.08 Mcal/kg、3.16Mcal/kg)的3种饲粮。试验结果表明:前两周饲料转化(采食/增重)均以 中能量组(3.08 Mcal/kg)最好,为1.4416±0.1199,但三种不同能量水平对肉仔鸡平均日增 重、平均日耗料、饲料转化率均差异不显著(P>0.05);后两周饲料转化仍以中能量组最好,为 1.6362±0.1346,且显著优于高能量组(P<0.05),而与低能组和中能组之间差异不显著,各 能量处理组蛋白质、粗纤维、钙的代谢率均差异不显著(P>0.05),而磷的代谢率却存在显著 差异(P<0.05),其中,以中等能量组的磷代谢率最高,平均为90.73%;3种能量水平下肉仔鸡 半净膛率、全净膛率均差异不显著(P>0.05),表明能量水平并不影响肉仔鸡屠宰性能。 相似文献
29.
日粮中添加柑桔皮粉对产蛋后期蛋鸡钙磷代谢的影响 总被引:1,自引:1,他引:1
雷风 《青海畜牧兽医杂志》2004,34(3):7-8
将 48周龄黄金褐蛋鸡 10只随机分成两组 ,对照组喂基础日粮 ,试验组用 2 5 %的柑桔皮粉等量替代基础日粮中的玉米 ,结果表明 :试验组钙磷表观代谢率为 65 79%、46 3 9% ,钙比对照组 (62 3 0 % )提高了 3 49个百分点 (P <0 0 5 ) ,磷比对照组 (4 7 5 2 % )降低了 1 13个百分点 (P >0 0 5 )。 相似文献
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