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Association of hyponatremia and hyperglycemia with outcome in dogs with congestive heart failure 总被引:1,自引:0,他引:1
Colleen A. Brady DVM DACVECC Dez Hughes BVSc MRCVS DACVECC Kenneth J. Drobatz DVM MSCE DACVECC DACVIM 《Journal of Veterinary Emergency and Critical Care》2004,14(3):177-182
Objective: To evaluate plasma sodium and glucose concentrations in dogs with congestive heart failure (CHF) prior to treatment and evaluate the differences between survivors and non‐survivors. Design: Retrospective study. Animals: Fifty‐nine dogs with CHF prior to receiving cardiac medication. Interventions: None. Measurements and main results: The mean plasma sodium concentration in dogs with CHF was below the reference range (144–156 mmol/L) and significantly lower (P=0.009) in non‐survivors (141±6 mmol/L) compared with survivors (147±4 mmol/L). The mean plasma glucose concentration was above the reference range (76–117 mg/dL) and significantly higher (P=0.004) in non‐survivors (128±52 mg/dL) compared with survivors (100±13 mg/dL). Forty‐four percent of non‐survivors had concurrent low plasma sodium and high plasma glucose concentrations, whereas no survivors had both abnormalities (P<0.0001). Conclusions: Lower plasma sodium and higher plasma glucose are associated with a worse outcome in dogs with CHF. 相似文献
13.
Julie M. Barr BS Safdar A. Khan DVM MS PhD DABVT Sheila M. McCullough DVM MS DACVIM Petra A. Volmer DVM MS DABVT DABT 《Journal of Veterinary Emergency and Critical Care》2004,14(3):196-202
Objective: To correlate the sodium chloride dosage and the serum sodium concentration to clinical signs, to determine if the dosage of homemade play dough (and, therefore, sodium chloride) is the most reliable way to predict clinical signs and prognosis, and to review previously reported treatment options. Design: Retrospective case series. Animals: Fourteen dogs with a history of homemade play dough ingestion. Procedure: Cases were examined for each animal's signalment including body weight, age, approximate amount of play dough ingested, the estimated sodium chloride dosage, clinical signs, serum sodium concentration, and outcome when available. The literature was reviewed to determine pathophysiology and treatment regimens. Results: Twelve of 14 dogs (86%) that ingested homemade play dough showed clinical signs. Vomiting (9 of 14, 64%), polydipsia, and seizures (4 of 14 each, 29%) were the most common signs followed by polyuria, tremors (3 of 14 each, 21%), and hyperthermia (2 of 14, 14%). The lowest calculated dosage associated with objective clinical signs was 1.9 g/kg. Seizures were reported in all animals with serum sodium levels greater than 180 mEq/L. Conclusions and clinical relevance: Homemade play dough ingestion can be a serious and life‐threatening problem. Many factors can contribute to the toxicity of homemade play dough. This study indicates that the serum sodium concentration is a more reliable indicator of the clinical course of the toxicity rather than the amount of play dough and, therefore, the dosage of sodium chloride ingested. Treatment should be based on a clinical evaluation of the patient and laboratory results, and consists of controlling seizures, reducing serum sodium concentrations slowly, and supportive care. 相似文献
14.
不同锌源对断奶小鼠生长及机体抗氧化能力的影响 总被引:9,自引:1,他引:9
选用断奶小鼠72只作为研究对象,随机分为3组(对照组,硫酸锌组和蛋氨酸锌组),每组设4个重复。测定体重、组织锌含量及相关生理生化指标,以研究硫酸锌、蛋氨酸锌2种不同锌供给形式对机体的生长效应及抗氧化能力的影响。结果表明,硫酸锌组和蛋氨酸锌组均能不同程度地提高小鼠体重,蛋氨酸锌组小鼠体重显著高于对照组与硫酸锌组(P<0.05)。饲粮中添加硫酸锌可提高小鼠肝脏和血清中的锌含量(P>0.05);蛋氨酸锌组小鼠肝脏和血清锌含量高于对照组(P<0.05)及硫酸锌组(P>0.05)。2种锌源均显著提高碱性磷酸酶(AKP)、谷胱甘肽过氧化物酶(GSHPx)活性(P<0.05),不同锌源间无明显差异(P>0.05)。添加不同的锌源不同程度地提高总抗氧化能力(TAOC)、总SOD(TSOD)、铜锌超氧化物歧化酶(CuZnSOD)活性(P<0.05),蛋氨酸锌组TAOC、TSOD显著高于硫酸锌组(P<0.05)。添加锌显著降低NO含量(P<0.05),蛋氨酸锌效果显著强于硫酸锌(P<0.05);一氧化氮合酶(NOS)活性表现出与NO相反的趋势(P>0.05)。 相似文献
15.
Effects of Moringa oleifera silage on milk yield,nutrient digestibility and serum biochemical indexes of lactating dairy cows 下载免费PDF全文
B. Zeng J. J. Sun T. Chen B. L. Sun Q. He X. Y. Chen Y. L. Zhang Q. Y. Xi 《Journal of animal physiology and animal nutrition》2018,102(1):75-81
This study investigated the effects of Moringa oleifera (MO) as a partial substitute of alfalfa hay on milk yield, nutrient apparent digestibility and serum biochemical indexes of dairy cows. MO was harvested at 120 days post‐seeding. Fresh MO was cut, mixed with chopped oat hay (425:575 on a DM basis), ensiled and stored for 60 days. Sixty healthy Holstein dairy cows were allocated to one of three groups: NM (no MO or control), LM (low MO; 25% alfalfa hay and 50% maize silage were replaced by MO silage) or HM (high MO; 50% alfalfa hay and 100% maize silage were replaced by MO silage). The feeding trial lasted 35 days. The LM and HM diets did not affect dry matter (DM) intake, milk yield or milk composition (lactose, milk fat, milk protein and somatic cell count). The apparent digestibility of DM and NDF was lower for HM group than NM group. Additionally, there were no significant differences in serum biochemical indexes between the LM and NM groups. The HM group had lower serum concentrations of total cholesterol, high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol and higher serum concentrations of urea than the NM group. The partial replacement of alfalfa hay (≤50%) and maize silage with MO silage had no negative effects on milk yield, in vivo nutrient apparent digestibility or serum biochemical indexes of lactating cows. 相似文献
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17.
B. Poźniak K. Motykiewicz‐Pers T. Grabowski M. Świtała 《Journal of veterinary pharmacology and therapeutics》2018,41(1):163-165
The aim of this study was to assess the influence of growth on the pharmacokinetics of sodium salicylate (SS) in male turkeys. SS was administered intravenously at a dose of 50 mg/kg. Plasma drug concentrations were assessed by high‐performance liquid chromatography, and pharmacokinetic parameters were calculated by noncompartmental analysis. As the age increased from 6 to 13 weeks (body weight increase from 2.35 to 9.43 kg), median body clearance decreased from 1.34 to 0.87 ml/min/kg. This caused a significant increase in the median mean residence time from 3.42 to 4.44 hr. Elimination phase proved to be biphasic and two elimination half‐lives (T1/2el) were distinguished. Whereas T1/2el1 was found to increase with age by 128%, T1/2el2 represented a later but faster and less age‐dependent phase of elimination (increase by 56% in the respective groups). Volume of distribution decreased with age. These effects may lead to different therapeutic response to SS in turkeys of different age and body weights. 相似文献
18.
A pot experiment was conducted in a climate‐controlled greenhouse to investigate the growth, physiology and yield of potato in response to salinity stress under biochar amendment. It was hypothesized that addition of biochar may improve plant growth and yield by mitigating the negative effect of salinity through its high sorption ability. From tuber bulking to harvesting, the plants were exposed to three saline irrigations, that is 0, 25 and 50 mm NaCl solutions, respectively, and two levels of biochar (0 % and 5 % W/W) treatments. An adsorption study was also conducted to study the Na+ adsorption capability of biochar. Results indicated that biochar was capable to ameliorate salinity stress by adsorbing Na+. Increasing salinity level resulted in significant reductions of shoot biomass, root length and volume, tuber yield, photosynthetic rate (An), stomatal conductance (gs), midday leaf water potential, but increased abscisic acid (ABA) concentration in both leaf and xylem sap. At each salinity level, incorporation of biochar increased shoot biomass, root length and volume, tuber yield, An, gs, midday leaf water potential, and decreased ABA concentration in the leaf and xylem sap as compared with the respective non‐biochar control. Decreased Na+, Na+/K+ ratio and increased K+ content in xylem with biochar amendment also indicated its ameliorative effects on potato plants in response to salinity stress. The results suggested that incorporation of biochar might be a promising approach for enhancing crop productivity in salt‐affected soils. 相似文献
19.
硼氢化钠的水解产物是一种新的储氢材料,其良好的可逆储氢能力在5MPa氢气压力真空条件下3分钟后在室温下吸收氢150。根据报道,它已被证明,这两种改变的催化剂NaBH4水解和添加催化剂直接插入接口是两个非常有效进一步提高接口的储氢容量。对hpsb-y2o3脱氢TiO2分别掺杂均达到重量2.4%和重量4.6%。重要的是对hpsb-y2o3可逆的脱氢能力不下降后成功———超循环。相比之下,对hpsb-ceo2可逆脱氢高达到重量5.9%,在室温下5分钟后3MPa氢气压力150氢吸附。 相似文献
20.
Estimating future fluxes of CH4 between land and atmosphere requires well-conceived process-based biogeochemical models. Current models do not represent the anaerobic oxidation of methane (AOM) in land surface soils, in spite of increasing evidence that this process is widespread. Our objective was to determine whether AOM, or potential AOM, commonly occurs in 20 hydromorphic soils spanning a wide range of chemical properties. Bulk soil samples were collected under shallow water near the shoreline of 15 recently drained fish ponds in southern Bohemia (Czech Republic), as well as from below the water table at 3 peatland locations in northeast Scotland and 2 acid sulfate soils on the southern coast of Finland. Each soil slurry was incubated under both oxic and anoxic conditions, with or without the addition of alternative electron acceptors (SO42− and NO3−) or H2PO4−. Here, “oxic” and “anoxic” conditions refer to anoxic soil respectively incubated in a headspace containing air or argon. Using the isotope dilution method, we determined the gross production and oxidation rates of CH4 after 2 days incubation under oxic headspace conditions, and after 2, 21 and 60 days incubation under anoxic conditions. Large differences in net CH4 fluxes were observed between soil types and between incubation conditions. AOM was detected in each of the 20 bulk soil samples, which spanned >6 pH units and 2 orders of magnitude in organic C content. Significant positive relationships were found between AOM and gross CH4 production rates under anoxic conditions, resulting in AOM rates that were sometimes higher than CH4 oxidation rates under oxic headspace conditions. There was no relationship between net and gross CH4 production rates, such that 2 soil types could display similar low net rates, yet conceal very large differences in gross rates. The effects of alternative electron acceptors on AOM were idiosyncratic and resulted in no net trend. We did find, however, a negative effect of SO42− and H2PO4− on gross CH4 production rates under anoxic and oxic conditions respectively. Under oxic headspace conditions, CH4 oxidation was related to soil organic C content. Taken collectively, our results suggest that AOM, or potential AOM, is prevalent over a wide range of soil types, that AOM may contribute substantially to CH4 oxidation in soils, and that AOM in soils should be integrated to current process-based CH4 cycling models. 相似文献