CORRECTION OF ANGULAR DEFORMITY BY ASYMMETRIC PHYSEAL GROWTH AND BONE REMODELLING

Angular deformities of 25 or 37 degrees valgus were created by transverse wedge osteotomies in the diaphysis of the radius in 3-month-old Cocker Spaniels. Spontaneous correction was judged from radiographs until skeletal maturity. The magnitude of correction was estimated, using the opposite normal leg as a control. Asymmetrical physeal growth corrected the induced angulation between the proximal and distal radial joint plane surfaces (joint plane angle). The average correction of the joint plane angle was 80% in the 25 degree group, and 72% in the 37 degree group. Bone remodeling of the radial shaft corrected the induced diaphyseal angulation by 50% in both groups during the study.     

Ope Pot Synthesis and Characterization of Safener R-28725

The title compound was synthesized by a one pot synthesis method with ethanolamine,ketone and dichloroacetyl chloride.The product was characterization by IR,^1H-NMR,UV,and elementary analysis.     

含N三臂类肽的合成

利用胺分子中氮原子成键的空间特征，接上3个含有S，N杂原子的氨基酸侧链从而合成了穴醚状含N三臂类肽，其独特的分子结构对客体识别具有重要的实践价值．     

三氟甲基侧取代氧、氮、硫杂大环化合物的合成和分子结构

合成了两个三氟甲基侧取代氧、氮、硫杂大环化合物（１、２），用ＩＲ、＾１ＨＮＭＲ、ＭＳ和元素分析作表征；用ＡＭ１方法计算了它们的电子结构，并根据计算结果给出了几何构型。     

芝麻苗期干旱生理生化指标响应特征及其基因表达分析

为建立芝麻抗旱性快速鉴定体系及筛选芝麻抗旱品种，采用盆栽反复干旱法，设置正常水分（CK）和干旱胁迫（DS）两种处理，对31份芝麻材料进行生理生化指标测定和综合评价，同时利用qRT-PCR检测SOD合成相关基因的表达量。结果表明：芝麻苗期O^₂、可溶性糖（SS）、脯氨酸（Pro）含量和超氧化物歧化酶（SOD）、过氧化物酶（POD）活性与CK相比均显著上升，各指标综合抗旱系数和抗旱指数的变异系数最高的分别是SOD（98.64%）和O^₂（154.01%）；抗旱指数与O^₂含量、SOD活性呈极显著正相关关系，这两个指标可作为芝麻苗期抗旱性鉴定的重要指标。聚类分析将31份芝麻材料划分为5类抗旱类型，分别为高抗型、中抗型、低抗型、低感型和高感型。利用综合评价方法，筛选出高抗材料2份（‘汾芝10号’和‘豫-11-1’），中抗旱材料4份，低抗旱材料9份，敏感材料10份，高感材料5份；筛选出O^₂含量和SOD活性可作为芝麻种质资源苗期抗旱特性快速鉴定的指标。     

Chemical Synthesis and Structure-Activity Relationship Study Yield Desotamide a Analogues with Improved Antibacterial Activity

Desotamides A, a cyclohexapeptide produced by the deep-sea-derived Streptomyces scopuliridis SCSIO ZJ46, displays notable antibacterial activities against strains of Streptococcus pnuemoniae, Staphylococcus aureus, and methicillin-resistant Staphylococcus epidermidis (MRSE). In this study, to further explore its antibacterial potential and reveal the antibacterial structure-activity relationship of desotamides, 13 cyclopeptides including 10 new synthetic desotamide A analogues and wollamides B/B1/B2 were synthesized and evaluated for their antibacterial activities against a panel of Gram-positive and -negative pathogens. The bioactivity data reveal that residues at position II and VI greatly impact antibacterial activity. The most potent antibacterial analogues are desotamide A4 (13) and A6 (15) where l-allo-Ile at position II was substituted with l-Ile and Gly at position VI was simultaneously replaced by d-Lys or d-Arg; desotamides A4 (13) and A6 (15) showed a 2–4-fold increase of antibacterial activities against a series of Gram-positive pathogens including the prevalent clinical drug-resistant pathogen methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 8–32 μg/mL compared to the original desotamide A. The enhanced antibacterial activity, broad antibacterial spectrum of desotamides A4 and A6 highlighted their potential as new antibiotic leads for further development.     

益智药乙拉西坦的合成和结构表征

以2-溴丁酸甲醵为起始原料，经氨解反应、N-烷基化反应合成了乙拉西坦，总收率为45.6％，改进后的工艺路线反应时间缩短、收率提高;并用IR、^1HNMR、^13CNMR对乙拉西坦进行了结构表征．     

湖南林业综合行政执法改革试点研究报告

2004年3月,根据国家林业局的部署,湖南省在会同县进行了“现有的资源林政执法队伍明确为林业综合行政执法机构”试点。重点对林业综合行政执法的发展前景及实施综合行政执法对林业主管部门行政管理体制改革的影响,进行了探索和研究。调研表明:林业综合执法势在必行,它能够排解现行林业行政执法体系中存在的问题,缓解林业执法体系中传统惯性大、磨合期长的不利因素。     

偏置双曲柄滑块机构设计

偏置双曲柄滑块机构不仅具有k>3的超急回运动特性,而且具有可变急回运动特性,机构中各构件尺寸一定时,仅仅改变其相对安装位置,便可获得不同的行程速比系数。本文分析偏置双曲柄滑块机构的急回运动特性,给出了按最小传动角设计偏置双曲柄滑块机构的设计方法和设计曲线。     

2,3,4-三羟基二苯酮的催化合成研究

讨论2了2，3，4=三羟基二苯酮的催化合成诬蔑应运 焦性没食子酸为起始原料，在惰性气体保护和催化剂（ZnCl2,AlCl3或SOCl2)的存在下，在芳香烃与水组成的二元混合溶剂中，与三氯甲苯反应，经过芳香烃溶剂的后处理，可以得到2，3，4-三羟基二苯酮，产率最高达87%，该方法的优点在于原料易得，操作条件简单，易于控制，收率稳定，产品质量高，成本低。