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Abstract CASE HISTORY: A 5-year-old entire female Huntaway from a sheep and beef farm was one of four dogs that developed clinical signs including hypersalivation, depression, blindness and ataxia after the death of another dog. A 4-year-old female Huntaway farm dog from a second farm was observed to be sitting down more often than usual on the day after being fed part of a calf carcass that had been treated with an abamectin pour-on. CLINICAL FINDINGS: The first dog was ataxic and depressed but did respond to sound. The second dog presented with an acute onset of blindness, mydriasis, absence of a menace response, hypersalivation, gait abnormalities (e.g. high stepping gait and ataxia), and depression. Other presenting signs included muscle tremors, dehydration and difficulty eating. No abnormalities were detected from routine haematology and biochemistry. Analysis of samples of plasma from both dogs revealed concentrations of abamectin of 0.149 mg/L and 0.260 mg/L for the first and second dogs, respectively. Buccal swabs taken from the first dog for DNA testing for the ABCB1 gene mutation, gave a negative result. DIAGNOSIS: In addition to the presenting signs which suggested a toxicosis, both dogs had measurable concentrations of abamectin in plasma confirming exposure. CLINICAL RELEVANCE: Farm dogs exposed to concentrated pour-on products containing abamectin have been poisoned and recover or die. The product labels do not carry any warnings as to the risk of poisoning to dogs. This paper discusses two incidents affecting six farm dogs, but the authors are aware of more toxicoses in farm dogs exposed to abamectin. 相似文献
23.
An 11-year-old Thoroughbred mare was diagnosed with sialolithiasis of the right parotid salivary duct. A firm nonpainful subcutaneous mass was palpable in the right maxillary region adjacent to premolar 4 (tooth 108). Radiographic and ultrasonographic examinations identified a discrete mineralised ovoid mass that was hyperechoic and produced an acoustic shadow. Surgical excision of the mass was performed under standing sedation using a transcutaneous approach and the excised sialolith submitted for histopathological and mineral composition analyses. Histological examination found no evidence of a nidus at the sialolith's core. Mineral analysis of the sialolith revealed its composition to be 40% calcium phosphate (apatite) and 60% calcium carbonate. The mare recovered with no post-operative complications and was clinically unremarkable 2 years later. 相似文献
24.
Evaluation of Patients with Community‐Acquired Pneumonia Caused by Zoonotic Pathogens in an Area with a High Density of Animal Farms 下载免费PDF全文
E. G. W. Huijskens L. A. M. Smit J. W. A. Rossen D. Heederik M. Koopmans 《Zoonoses and public health》2016,63(2):160-166
Intensive animal farming could potentially lead to outbreaks of infectious diseases. Clinicians are at the forefront of detecting unusual diseases, but the lack of specificity of zoonotic disease symptoms makes this a challenging task. We evaluated patients with community‐acquired pneumonia (CAP) with known and unknown aetiology in an area with a high livestock density and a potential association with animal farms in the proximity. Between 2008 and 2009, a period coinciding with a large Q fever outbreak in the Netherlands, patients with CAP were tested for the presence of possible respiratory pathogens. The presence and number of farm animals within 1 km of the patients' home address were assessed using geographic information system (GIS) and were compared between cases and age‐matched control subjects. Of 408 patients with CAP, pathogens were detected in 275 (67.4%) patients. The presence of sheep and the number of goats were associated with CAP caused by Coxiella burnetii in a multiple logistic regression model (P < 0.05). CAP with unknown aetiology was not associated with the presence of animal farms (P > 0.10). The use of GIS in combination with aetiology of CAP could be potentially used to target diagnostics and to identify outbreaks of rare zoonotic disease. 相似文献
25.
A study compared the spread of sweet potato virus disease (SPVD) into crops of two moderately resistant and initially SPVD-free sweet potato cultivars in northern and southern Mpigi, Uganda. Whiteflies, the vector of sweet potato chlorotic stunt crini virus (SPCSV), a component cause of SPVD, were similarly abundant in farmers' sweet potato fields around Namulonge in northern Mpigi, and Kanoni in southern Mpigi. However, mean incidence of SPVD in farmers' crops neighbouring the trials was higher at Kanoni (13.3%) than at Namulonge (2.8%). Furthermore, spread of SPVD into initially SPVD-free sweet potato plots of two only moderately resistant cultivars was greater in plots at Kanoni than in plots at Namulonge. The SPVD-resistant New Kawogo was the most common cultivar grown in farmers' fields at Namulonge and had few diseased plants, whereas susceptible cultivars with relatively high incidences of disease predominated at Kanoni. Final SPVD incidence in each trial was positively correlated with a measure combining the proximity and level of inoculum in surrounding fields. The study demonstrates the importance of local SPVD inoculum in determining the rate of spread of the disease into fields and implies that the widespread cultivation of a resistant variety limits infection of susceptible cultivars grown nearby. 相似文献
26.
Joseph R. Sara Wilmien J. Luus-Powell Susan B. Fogelson Hannes Botha Theresa C. Guillette Willem J. Smit Andre Hoffman Katlego D. Kunutu Jeremy P. Koelmel John A. Bowden 《Journal of fish diseases》2020,43(10):1185-1199
Pansteatitis is the leading cause for the decline in Nile crocodile populations and the sporadic mortality of fish in the Olifants River System, South Africa. To determine the prevalence of this disease in lentic systems, Mozambique tilapia, Oreochromis mossambicus, were collected from Lake Loskop, Lake Flag Boshielo, Phalaborwa Barrage and Lake Luphephe-Nwanedi. The former three impoundments are located within the main stem of the Olifants River, while the latter, which is geographically isolated and situated in the Limpopo River System, served as a reference site. Mesenteric adipose, liver, serosa of the swim bladder, gill and the skeletal muscle of fish sampled were examined for gross and microscopic evidence of pansteatitis. Microscopically observed changes were used to statistically compare pansteatitis prevalence between samples and sites. Based on histopathological evaluation, the adipose tissue in the liver, swim bladder serosa and coelom from severely debilitated individuals showed the most significant pathological changes. Lesions indicative of steatitis were observed in fish collected from Lake Loskop (75%), Lake Flag Boshielo (22%) and Lake Luphephe-Nwanedi (15%). Further investigation is warranted to understand the pervasiveness and mechanisms driving pathological changes of pansteatitis at Lake Flag Boshielo, Phalaborwa Barrage and Lake Luphephe-Nwanedi. 相似文献
27.
Ingeborg van den Beukel Remco Klaassen Guus B Smit Regina G
D
M van Kleef Marga Oortgiesen 《Pest management science》1999,55(10):1031-1033
Species-specific agonist binding regions of nicotinic acetylcholine receptors (nAChR) were examined. Imidacloprid and physostigmine (Phy) selectively activated insect nAChR composed of Drosophila second alpha-like subunit (SAD) and chick β2, in contrast to rat α7 nAChR. The Phy-activated currents were α-bungarotoxin (α-BGT) sensitive, suggesting activation at the agonist binding loop C. Several SAD-α7 chimeras were constructed, by switching agonist binding regions, and expressed in oocytes. Though none of the chimeras was activated by a range of nicotinic agonists, [125I]α-BGT binding revealed homomeric assembly of all chimeric cDNAs. Phy differentially displaced [125I]α-BGT from the nAChR chimeras, suggesting that the β subunit is not involved in Phy binding, and that Phy targets the insect agonist binding loop C. 相似文献
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29.
To explore whether litter quality could alter differences in N-dynamics between soil types, we compared spruce and beech growing
on soils with parent material sandstone and limestone, and beech and hornbeam on acid marl and limestone. We measured pH,
organic matter content, C:N ratio, soil respiration and net N-mineralization of the organic layer and the mineral topsoil
in a laboratory incubation experiment and estimated gross N-mineralization and immobilization with a simulation model. Species
effects were restricted to the organic layer, but higher mass for low-degradable species was compensated by higher process
rates for high-degradable ones, so N-dynamics per square metre did not differ. Also, the mineral topsoil was not affected
by litter quality, which may have been overruled by soil conditions. Forest soils formed from different parent materials,
however, clearly differed in N-dynamics, although different from expectations for net N-mineralization. Sandstone showed low
respiration and gross N-mineralization, but net N-mineralization was higher than expected, probably due to low microbial N-demand.
In contrast, limestone, and to some extent acid marl, showed high respiration and gross N-release, but lower net N-mineralization
than expected, because microbial immobilization was also high. Simulated gross N-mineralization even showed a negative instead
of positive correlation with net N-mineralization, probably due to the strong increase in immobilization when gross N-mineralization
is high. The shift in microbial N-demand may in turn be related to a more general shift from bacteria to fungi over pH-gradients. 相似文献
30.
Oliveira Bruna R. F. Smit Martijn P. J. van Paassen Leon A. Grotenhuis Tim C. Rijnaarts Huub H. M. 《Journal of Soils and Sediments》2017,17(1):286-298
Journal of Soils and Sediments - In delta areas, dense networks of canals have been developed through time and have to be periodically dredged. Lowering the groundwater level in delta areas deepens... 相似文献