Clementine observations of the aristarchus region of the moon

Multispectral and topographic data acquired by the Clementine spacecraft provide information on the composition and geologic history of the Aristarchus region of the moon. Altimetry profiles show the Aristarchus plateau dipping about 1 degrees to the north-northwest and rising about 2 kilometers above the surrounding lavas of Oceanus Procellarum to the south. Dark, reddish pyroclastic glass covers the plateau to average depths of 10 to 30 meters, as determined from the estimated excavation depths of 100- to 1000-meter-diameter craters that have exposed materials below the pyroclastics. These craters and the walls of sinuous rilles also show that mare basalts underlie the pyroclastics across much of the plateau. Near-infrared images of Aristarchus crater reveal olivine-rich materials and two kilometer-sized outcrops of anorthosite in the central peaks. The anorthosite could be either a derivative of local magnesium-suite magmatism or a remnant of the ferroan anorthosite crust that formed over the primordial magma ocean.     

Volcanism on Mercury: evidence from the first MESSENGER flyby

The origin of plains on Mercury, whether by volcanic flooding or impact ejecta ponding, has been controversial since the Mariner 10 flybys (1974-75). High-resolution images (down to 150 meters per pixel) obtained during the first MESSENGER flyby show evidence for volcanic vents around the Caloris basin inner margin and demonstrate that plains were emplaced sequentially inside and adjacent to numerous large impact craters, to thicknesses in excess of several kilometers. Radial graben and a floor-fractured crater may indicate intrusive activity. These observations, coupled with additional evidence from color images and impact crater size-frequency distributions, support a volcanic origin for several regions of plains and substantiate the important role of volcanism in the geological history of Mercury.     

Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4

The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d (extended loop) are surprisingly different. Nonetheless, a critical sulfotyrosine on CCR5 and on 412d induces similar structural rearrangements in gp120. These results now provide a framework for understanding HIV-1 interactions with the CCR5 N terminus during viral entry and define a conserved site on gp120, whose recognition of sulfotyrosine engenders posttranslational mimicry by the immune system.     

Atmospheric Effects of Pollutan: Pollutants which affect clouds are most likely to produce modifications in weather and climate

We have argued that aerosols are probably the principal agents by which pollutants may affect weather and climate. They are most likely to act by influencing the structure and distribution of clouds. On the local scale, the effects of pollutants on some aspects of weather are unmistakable. The effects of man-made pollutants on global climate are a matter of debate, but they may already be significant.     

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies

The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs) exist that broadly neutralize HIV-1, HIV-1 envelope immunogens do not induce these antibody specificities. Here we demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin. Thus, current HIV-1 vaccines may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus. These results may have important implications for generating effective neutralizing antibody responses by using HIV-1 vaccines.     

Bottom Velocity Observations Directly under the Gulf Stream

Speeds as high as 44 centimeters per second were observed 200 meters above the ocean bottom under the Gulf Stream at 70 degrees W longitude and were associated with time-dependent motion that had a speed range of 40 centimeters per second and a time scale of about 30 days. These deep current fluctuations appear to be coupled with fluctuations in the surface position of the Stream and with surface and bottom current fluctuations 200 kilometers to the north.