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排序方式: 共有354条查询结果,搜索用时 31 毫秒
81.
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Buescher JM Liebermeister W Jules M Uhr M Muntel J Botella E Hessling B Kleijn RJ Le Chat L Lecointe F Mäder U Nicolas P Piersma S Rügheimer F Becher D Bessieres P Bidnenko E Denham EL Dervyn E Devine KM Doherty G Drulhe S Felicori L Fogg MJ Goelzer A Hansen A Harwood CR Hecker M Hubner S Hultschig C Jarmer H Klipp E Leduc A Lewis P Molina F Noirot P Peres S Pigeonneau N Pohl S Rasmussen S Rinn B Schaffer M Schnidder J Schwikowski B Van Dijl JM Veiga P Walsh S Wilkinson AJ Stelling J Aymerich S 《Science (New York, N.Y.)》2012,335(6072):1099-1103
83.
P Jull E Browne BS Boufana S Schöniger E Davies 《Journal of Feline Medicine and Surgery》2012,14(9):646-649
Clinical summary: A 4-year-old Birman cat was presented with marked obtundation and non-ambulatory tetraparesis. Two well-demarcated, intra-axial T2-hyperintense, T1-hypointense structures, which did not contrast enhance, were evident on magnetic resonance imaging (MRI). Histopathology of the structures revealed metacestodes that were morphologically indicative of larval stages of Taenia species. Polymerase chain reaction amplification of a fragment within the 12S rRNA gene confirmed the subspecies as Taenia serialis. Practical significance: This is the first report of MRI findings of cerebral coenurosis caused by T serialis in a cat. Early MRI should be considered an important part of the diagnostic work-up for this rare clinical disease, as it will help guide subsequent treatment and may improve the prognosis. 相似文献
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Massey EJ Sundstedt A Day MJ Corfield G Anderton S Wraith DC 《Veterinary immunology and immunopathology》2002,87(3-4):357-372
Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease commonly employed as a model for multiple sclerosis. Extensive studies have demonstrated that EAE may be prevented or ameliorated by the intranasal administration of soluble peptides representing encephalitogenic epitopes. There is increasing evidence that this peptide administration may function via the generation of regulatory cells. The mechanism of action of these cells remains controversial and it seems likely that it may vary between experimental models. At present the majority of work on regulatory cells has centred on characterising naturally occurring regulators, or those generated artificially ex vivo, and less is known about induced regulatory cells produced following peptide administration. This report aims to briefly outline the evidence for the existence of natural regulatory T cells and to introduce the sub-types of induced regulatory T cells now recognised.In several of these regulatory cell systems investigated to date, interleukin-10 (IL-10) has been shown to be important in cell function. This has not been directly investigated in a model employing peptide therapy to induce peripheral tolerance, hence the purpose of this study was to investigate the role of IL-10 in the generation of these regulatory cells. This work has employed both a TCR transgenic mouse system, for predominantly in vitro studies of cell function, and an IL-10 knock-out mouse strain to investigate in vivo disease protection. The results summarised in this report demonstrate that IL-10 is fundamentally important in the generation of disease protection following intranasal peptide therapy. 相似文献
87.
Effect of hemi-circumferential periosteal transection and elevation in foals with experimentally induced angular limb deformities 总被引:1,自引:0,他引:1
Read EK Read MR Townsend HG Clark CR Pharr JW Wilson DG 《Journal of the American Veterinary Medical Association》2002,221(4):536-540
OBJECTIVE: To evaluate the effect of hemi-circumferential periosteal transection and elevation (HCPTE) in foals with, experimentally induced angular limb deformities. DESIGN: Prospective study. ANIMALS: 10 healthy foals. PROCEDURE: When foals were 30 days old, transphyseal bridge implants were placed on the lateral aspects of both distal radial physes. At 90 days of age (or when 15 degrees of angulation had developed), implants were removed, and HCPTE was performed on 1 limb. Foals were confined in small pens after surgery; the front feet of the foals were rasped weekly to maintain medial-to-lateral hoof wall balance. Dorsopalmar radiographic projections of the carpi were obtained before HCPTE and 2, 4, 6, 8, and 48 weeks later. RESULTS: At the time of transphyseal bridge removal and HCPTE, both treated and control limbs were observed to have a significantly greater carpal valgus, compared with the initial degree of angulation at 30 days of age. Following HCPTE or sham surgery, all limbs straightened over the subsequent 2 months of the study. Median angulation was not significantly different between treated and control limbs at any time during the study. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that in foals with experimentally induced limb deformities, HCPTE was no more effective than stall confinement and hoof trimming alone for correction of the deformity. 相似文献
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Jesús Jaime Guerra-Santos Rosa María Cerón-Bretón Julia Griselda Cerón-Bretón Diana Lizett Damián-Hernández Reyna Cristina Sánchez-Junco Emma del Carmen Guevara Carrió 《林业研究》2014,25(1):129-134
We report the results of carbon stored in soil and aboveground biomass from the most important area of mangroves in Mexico,with dominant vegetation of Red mangrove(Rhizophora mangle L.),Black mangrove(Avicennia germinans L.),white mangrove(Laguncularia racemosa Gaertn.)and button mangrove(Conocarpus erectus L.).We sampled soils with high fertility during the dry season in 2009 and 2010at three sites on Atasta Peninsula,Campeche.We used allometric equations to estimate above ground biomass(AGB)of trees.AGB was higher in C.erectus(253.18±32.17 t·ha-1),lower in A.germinans(161.93±12.63t·ha-1),and intermediate in R.mangle(181.70±16.58 t·ha-1)and L.racemosa(206.07±19.12 t·ha-1).Of the three studied sites,the highest absolute value for AGB was 279.72 t·ha-1in button mangrove forest at any single site.Carbon stored in soil at the three sites ranged from36.80±10.27 to 235.77±66.11 t·ha-1.The Tukey test(p0.05)made for AGB was higher for black mangrove showed significant differences in soil carbon content between black mangrove and button mangrove.C.erectus had higher AGB compared with the other species.A.germinans trees had lower AGB because they grew in hypersaline environments,which reduced their development.C.erectus grew on higher ground where soils were richer in nutrients.AGB tended to be low in areas near the sea and increased with distance from the coast.A.germinans usually grew on recently deposited sediments.We assumed that all sites have the same potential to store carbon in soil,and then we found that there were no significant differences in carbon content between the three samples sites:all sites had potential to store carbon for long periods.Carbon storage at the three sampling sites in the state of Campeche,Mexico,was higher than that reported for other locations. 相似文献
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Emma L. Gillingham Jessica L. Hall Richard J. Birtles Kevin J. Bown Jolyon M. Medlock Robert Smith Kayleigh M. Hansford Jenny C. Warner Matthew Dryden Maaike E. Pietzsch 《Zoonoses and public health》2020,67(5):591-599
Lyme borreliosis (LB) is a tick‐borne disease caused by Borrelia burgdorferi sensu lato complex. In Europe, it is predominately transmitted by the sheep tick, Ixodes ricinus. Compared with other European countries, the United Kingdom (UK) is considered to have a low incidence of LB, although this varies regionally. To determine whether an association exists between tick bite consultations and LB incidence in the UK, retrospective questionnaires were sent to general practitioners (GPs) in high (Wiltshire), medium (Cumbria) and low (Wales) incidence areas. During 2011, the greatest incidence of consultations for tick bites was reported by GPs in Cumbria (204 consultations per 100,000 inhabitants), followed by Wiltshire (160 per 100,000 population) and Wales (54 per 100,000 population). In Wiltshire and Cumbria, GPs predominantly provided advice on tick removal, whilst Welsh GPs mostly advised patients on tick bite prevention. Focusing on Cumbria during 2011–2013, 72.5% of GPs removed ticks from patients (incidence of 101 consultations per 100,000 population), and more GPs diagnosed LB based on clinical features than laboratory‐confirmed diagnoses. To date, this is the first study to investigate the incidence of tick bite consultations and LB in England and Wales. 相似文献