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111.
Shocks in ion sputtering sharpen steep surface features 总被引:1,自引:0,他引:1
Chen HH Urquidez OA Ichim S Rodriquez LH Brenner MP Aziz MJ 《Science (New York, N.Y.)》2005,310(5746):294-297
We report a regime of ion beam sputtering that occurs for sufficiently steep slopes. High slopes propagate over large distances without dissipating the steepest features. Both the propagation velocity and the dynamically selected slope are universal, independent of the details of the initial shape of the surface. The resulting behavior can be understood as the propagation of a shock front that self-selects a stable slope, as has been previously observed in thin-film fluid flows. Experiments confirm predictions of the theory. An important implication of the propagative behavior at high surface slopes is that a pattern can be fabricated at a large length scale and, through uniform ion irradiation, reduced to a smaller length scale while preserving, or even sharpening, the sharpest features. 相似文献
112.
Hafezparast M Klocke R Ruhrberg C Marquardt A Ahmad-Annuar A Bowen S Lalli G Witherden AS Hummerich H Nicholson S Morgan PJ Oozageer R Priestley JV Averill S King VR Ball S Peters J Toda T Yamamoto A Hiraoka Y Augustin M Korthaus D Wattler S Wabnitz P Dickneite C Lampel S Boehme F Peraus G Popp A Rudelius M Schlegel J Fuchs H Hrabe de Angelis M Schiavo G Shima DT Russ AP Stumm G Martin JE Fisher EM 《Science (New York, N.Y.)》2003,300(5620):808-812
Degenerative disorders of motor neurons include a range of progressive fatal diseases such as amyotrophic lateral sclerosis (ALS), spinal-bulbar muscular atrophy (SBMA), and spinal muscular atrophy (SMA). Although the causative genetic alterations are known for some cases, the molecular basis of many SMA and SBMA-like syndromes and most ALS cases is unknown. Here we show that missense point mutations in the cytoplasmic dynein heavy chain result in progressive motor neuron degeneration in heterozygous mice, and in homozygotes this is accompanied by the formation of Lewy-like inclusion bodies, thus resembling key features of human pathology. These mutations exclusively perturb neuron-specific functions of dynein. 相似文献
113.
Receptors: localization and specificity of binding of serotonin in the central nervous system 总被引:2,自引:0,他引:2
S G Alivisatos F Ungar P K Seth L P Levitt A J Geroulis T S Meyer 《Science (New York, N.Y.)》1971,171(973):809-812
Formation of a Schiff base between the ethylamine residue of serotonin and an appropriate carbonyl residue at the receptor site may be among the forces holding serotonin onto the receptor. Reduction of this imine may provide a means of permanently labeling receptors as a preliminary to their isolation. 相似文献
114.
Striatal nondopaminergic neurons: possible involvement in feeding and drinking behavior 总被引:1,自引:0,他引:1
D J Pettibone N Kaufman M C Scally E Meyer I Ulus L D Lytle 《Science (New York, N.Y.)》1978,200(4346):1175-1177
Intracaudate injections of kainic acid destroy striatal neurons containing acetylcholine and gamma-aminobutyric acid but leave dopaminergic nerve terminals in this brain region intact. Rats injected with the drug are aphagic and adipsic, and have other behavioral abnormalities strikingly similar to those seen in animals with lesions in the dopaminergic nigrostriatal bundle. 相似文献
115.
Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle 总被引:18,自引:0,他引:18
P Ruth A R?hrkasten M Biel E Bosse S Regulla H E Meyer V Flockerzi F Hofmann 《Science (New York, N.Y.)》1989,245(4922):1115-1118
Complementary DNAs for the beta subunit of the dihydropyridine-sensitive calcium channel of rabbit skeletal muscle were isolated on the basis of peptide sequences derived from the purified protein. The deduced primary structure is without homology to other known protein sequences and is consistent with the beta subunit being a peripheral membrane protein associated with the cytoplasmic aspect of the sarcolemma. The protein contains sites that might be expected to be preferentially phosphorylated by protein kinase C and guanosine 3',5'-monophosphate-dependent protein kinase. A messenger RNA for this protein appears to be expressed in brain. 相似文献
116.
117.
Two distinct suites of minerals included in natural diamond occur and probably represent different physical and chemical conditions during diamond growth. Minerals of the ultramafic suite appear to have equilibrated in the range 1000 degrees to 1300 degrees C between 45 and 65 kilobars, whereas the temperature range for minerals of the eclogitic suite is 850 degrees to 1250 degrees C. At present, models relating the partitioning of magnesium and iron between coexisting phases are not sufficiently rigorous to determine a value for the pressure of equilibration of these eclogitic suite inclusions. 相似文献
118.
The chiral fullerene C(76) was kinetically resolved by asymmetric osmylation providing an example of an optically active allotrope of a pure element. C(76) recovered from the treatment of racemic C(76) with OsO(4) and a chiral alkaloid ligand, showed a specific rotation [alpha](D) of -4000 degrees (> 97 percent enantiomeric excess) and a circular dichroism spectrum corresponding to the ultraviolet spectrum. Regenerated C(76) formed by reducing the asymmetrically osmylated C(76) with SnCl(2) was enriched in the opposite enantiomer. Analysis of the local curvature of the C(76) molecule indicated that OsO(4) should selectively add to 2 of the 30 types of bonds in C(76). This regioselectivity was supported chromatographically and interpreted in terms of the kinetic resolution. 相似文献
119.
Meyer C 《Science (New York, N.Y.)》1985,227(4693):1421-1428
The ores of chromite, nickel, copper, and zinc show a wide distribution over geologic time, but those of iron, titanium, lead, uranium, gold, silver, molybdenum, tungsten, and tin are more restricted. Many of the limitations to specific time intervals are probably imposed by the evolving tectonic history of Earth interacting with the effects of the biomass on the evolution of the earth's s surface chemistry. Photosynthetic generation of free oxygen and "carbon" contributes significantlly to the diversity of redox potentials in both sedimentary and igneous-related processes of ore formation, influencing the selection of metals at the source, during transport, and at the site of ore deposition. 相似文献
120.