Environmental change and Antarctic seabird populations

Recent changes in Antarctic seabird populations may reflect direct and indirect responses to regional climate change. The best long-term data for high-latitude Antarctic seabirds (Adélie and Emperor penguins and snow petrels) indicate that winter sea-ice has a profound influence. However, some effects are inconsistent between species and areas, some in opposite directions at different stages of breeding and life cycles, and others remain paradoxical. The combination of recent harvest driven changes and those caused by global warming may produce rapid shifts rather than gradual changes.     

Timing of millennial-scale climate change in Antarctica and Greenland during the last glacial period

A precise relative chronology for Greenland and West Antarctic paleotemperature is extended to 90,000 years ago, based on correlation of atmospheric methane records from the Greenland Ice Sheet Project 2 and Byrd ice cores. Over this period, the onset of seven major millennial-scale warmings in Antarctica preceded the onset of Greenland warmings by 1500 to 3000 years. In general, Antarctic temperatures increased gradually while Greenland temperatures were decreasing or constant, and the termination of Antarctic warming was apparently coincident with the onset of rapid warming in Greenland. This pattern provides further evidence for the operation of a "bipolar see-saw" in air temperatures and an oceanic teleconnection between the hemispheres on millennial time scales.     

Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection

Certain pathogens, such as Mycobacterium tuberculosis, survive within the hostile intracellular environment of a macrophage. To identify host factors required for mycobacterial entry and survival within macrophages, we performed a genomewide RNA interference screen in Drosophila macrophage-like cells, using Mycobacterium fortuitum. We identified factors required for general phagocytosis, as well as those needed specifically for mycobacterial infection. One specific factor, Peste (Pes), is a CD36 family member required for uptake of mycobacteria, but not Escherichia coli or Staphylococcus aureus. Moreover, mammalian class B scavenger receptors (SRs) conferred uptake of bacteria into nonphagocytic cells, with SR-BI and SR-BII uniquely mediating uptake of M. fortuitum, which suggests a conserved role for class B SRs in pattern recognition and innate immunity.     

PERSISTENT MITOSIS OF TRANSFUSED HOMOLOGOUS LEUKOCYTES IN CHILDREN RECEIVING ANTILEUKEMIC THERAPY

Temporary homologous bone marrow grafts were observed in three patients with acute leukemia, receiving intensive antileukemic treatment, following transfusion of peripheral blood cells from donors with chronic myelocytic leukemia. Persistent mitosis of the transfused cells, containing the Philadelphia chromosome marker, were detected by cytogenetic techniques 19, 39, and 52 days after transfusion.     

Regional synthesis of Mediterranean atmospheric circulation during the Last Glacial Maximum

Atmospheric circulation leaves few direct traces in the geological record, making reconstructions of this crucial element of the climate system inherently difficult. We produced a regional Mediterranean synthesis of paleo-proxy data from the sea surface to alpine altitudes. This provides a detailed observational context for change in the three-dimensional structure of atmospheric circulation between the Last Glacial Maximum (LGM, approximately 23,000 to 19,000 years ago) and the present. The synthesis reveals evidence for frequent cold polar air incursions, topographically channeled into the northwestern Mediterranean. Anomalously steep vertical temperature gradients in the central Mediterranean imply local convective precipitation. We find the LGM patterns to be analogous, though amplified, to previously reconstructed phases of enhanced meridional winter circulation during the Maunder Minimum (the Little Ice Age).