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401.
Keele BF Van Heuverswyn F Li Y Bailes E Takehisa J Santiago ML Bibollet-Ruche F Chen Y Wain LV Liegeois F Loul S Ngole EM Bienvenue Y Delaporte E Brookfield JF Sharp PM Shaw GM Peeters M Hahn BH 《Science (New York, N.Y.)》2006,313(5786):523-526
Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus (SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P. t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic (group M) and nonpandemic (group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1. 相似文献
402.
U. Schwittlick J. Junginger K. Hahn A. Habierski M. Hewicker‐Trautwein 《Anatomia, histologia, embryologia》2017,46(1):33-42
Histamine is an important mediator of many physiological processes including gastrointestinal function that acts via four different histamine receptors (H1R to H4R). Elevated histamine levels and increased HR messenger ribonucleic acid (mRNA) have been shown in humans with gastrointestinal disorders such as irritable bowel syndrome or allergic intestinal diseases. As there is limited knowledge concerning the distribution of histamine receptors (HR) in dogs, one aim of this study was to investigate the expression of histamine 1 receptor (H1R), histamine 2 receptor (H2R) and histamine 4 receptor (H4R) in the canine gastrointestinal tract at protein level using immunohistochemistry. Histamine 1 receptor, H2R and H4R were widely expressed throughout the canine gastrointestinal tract including epithelial, mesenchymal, neuronal and immune cells. In addition, in situ hybridisation was established for detecting canine H4R mRNA. Results showed H4R mRNA to be present in enterocytes, lamina propria immune cells and submucosal plexus in the duodenum and colon of nearly all investigated animals. The results elucidate the importance of HR in the canine gut and represent the basis for investigating their possible impact on canine inflammatory gastrointestinal disorders. 相似文献
403.
V S Blazer H L Walsh R P Braham C M Hahn P Mazik P B McIntyre 《Journal of fish diseases》2017,40(3):377-393
The prevalence and histopathology of neoplastic lesions were assessed in white sucker Catostomus commersonii captured at two Lake Michigan Areas of Concern (AOCs), the Sheboygan River and Milwaukee Estuary. Findings were compared to those observed at two non‐AOC sites, the Root and Kewaunee rivers. At each site, approximately 200 adult suckers were collected during their spawning migration. Raised skin lesions were observed at all sites and included discrete white spots, mucoid plaques on the body surface and fins and large papillomatous lesions on lips and body. Microscopically, hyperplasia, papilloma and squamous cell carcinoma were documented. Liver neoplasms were also observed at all sites and included both hepatocellular and biliary tumours. Based on land use, the Kewaunee River was the site least impacted by human activities previously associated with fish tumours and had significantly fewer liver neoplasms when compared to the other sites. The proportion of white suckers with liver tumours followed the same patterns as the proportion of urban land use in the watershed: the Milwaukee Estuary had the highest prevalence, followed by the Root, Sheboygan and Kewaunee rivers. The overall skin neoplasm (papilloma and carcinoma) prevalence did not follow the same pattern, although the percentage of white suckers with squamous cell carcinoma exhibited a similar relationship to land use. Testicular tumours (seminoma) were observed at both AOC sites but not at the non‐AOC sites. Both skin and liver tumours were significantly and positively associated with age but not sex. 相似文献
404.
João Costa Filho Mônica Yumi Tsuzuki Giovanni Lemos de Mello Luiz Cláudio Miletti Karim Hahn Lüchmann Carlos André da Veiga Lima-Rosa 《Journal Of Applied Aquaculture》2017,29(3-4):199-206
We investigated the growth of juvenile common snook (Centropomus undecimalis) reared at 25°C and 28°C and salinities of 0.3, 15, and 32 g L?1. Total length, weight, RNA/DNA, and protein/DNA ratios were determined after 90 days of experiment. Higher growth was observed at 28ºC compared with 25°C, at the same salinity. At 28°C and 15 g L?1 salinity, the weight (25.14 g) of juveniles was twice that of the juveniles reared at the lower temperature. At different salinities, only higher temperature affected growth, with higher weight values obtained at 15 g L?1 in comparison with 0.3 and 32 g L?1. Length was similar at 0.3 and 15 g L?1. The RNA/DNA ratio was greater in juveniles reared at a salinity of 15 g L?1 when compared with 0.3 and 32 g L?1. This study shows that the combination of higher temperature and intermediate salinity promotes better growth of common snook juveniles. 相似文献