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The skeletal development of three groups of great dane dogs, fed a diet composed according to the published nutritional requirements for dogs (controls) or with increased calcium or calcium and phosphorus content, was examined radiographically, histologically and biochemically. The diets were fed from the time the dogs first began eating food in addition to their dam's milk, until they were 17 weeks old. Thereafter, the calcium and phosphorus intakes of the dogs in the high calcium groups were normalised for a further 10 weeks. The dogs fed the high calcium diet without a proportionally high phosphorus intake became hypercalcaemic and hypophosphataemic, and had severe disturbances in skeletal development, growth, and mineralisation which were typical for rickets. After their calcium intake was normalised the lesions of rickets resolved but osteochondrotic lesions became apparent. The dogs fed the high calcium and phosphorus diet became slightly hypophosphataemic, their growth was retarded, and they had disturbances in skeletal development resembling osteochondrosis, which had only partly resolved after 10 weeks on the normal calcium and phosphorus diet.  相似文献   
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We tracked and monitored hurricane Anita over a 5-day period by using the SRI-operated Wide Aperture Research Facility (WARF) high-frequency skywave radar. The WARF-derived positions for Anita agreed to within +/- 19 kilometers of the coincident temporal positions along the National Hurricane Center's smooth track. Hurricane Anita passed near the open ocean-moored buoy EB-71 of the National Oceanic and Atmospheric Administration, and measurements of wind direction, wind speed, and significant wave height made during this period at the WARF and in situ at the buoy showed agreement of 7 degrees , 0.4 meter per second, and 0.5 meter, respectively. The WARF estimates of longshore coastal surface currents showed good agreement with measurements made at a moored current meter.  相似文献   
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The SNF1 gene plays a central role in carbon catabolite repression in the yeast Saccharomyces cerevisiae, namely that SNF1 function is required for expression of glucose-repressible genes. The nucleotide sequence of the cloned SNF1 gene was determined, and the predicted amino acid sequence shows that SNF1 encodes a 72,040-dalton polypeptide that has significant homology to the conserved catalytic domain of mammalian protein kinases. Specific antisera were prepared and used to identify the SNF1 protein. The protein was shown to transfer phosphate from adenosine triphosphate to serine and threonine residues in an in vitro autophosphorylation reaction. These findings indicate that SNF1 encodes a protein kinase and suggest that protein phosphorylation plays a critical role in regulation by carbon catabolite repression in eukaryotic cells.  相似文献   
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Considering the unique morphology (purposefully shaped polished bar with a groove) and composition (magnetic mineral with magnetic moment vector in the floating plane) of M-160, and acknowledging that the Olmec were a sophisticated people who possessed advanced knowledge and skill in working iron ore minerals, I would suggest for consideration that the Early Formative artifact M-160 was probably manufactured and used as what I have called a zeroth-order compass, if not a first-order compass. The data I have presented in this article support this hypothesis, although they are not sufficient to prove it. That M-160 could be used today as a geomagnetically directed pointer is undeniable. The original whole bar may indeed have pointed close to magnetic north-south. The groove functions well as a sighting mark, and the slight angle it makes with the axis of the bar appears to be the result of calibration rather than accident. A negative supporting argument is that M-160 looks utilitarian rather than decorative, and no function for the object other than that of a compass pointer has been suggested by anyone who has examined it critically. Whether such a pointer would have been used to point to something astronomical (zeroth-order compass) or to geomagnetic north-south (first-order compass) is entirely open to speculation. The observation of the family of Olmec site alignments 8 degrees west of north is a curiosity in its own right, and the possibility that these alignments have an astronomical or geomagnetic origin should be explored. I also believe that it is constructive to compare the first millennium Chinese, who used the lodestone compass for geomancy, with the Gulf Coast Olmec since both were agrarian-terrestrial societies. The Olmec's apparent concern with orientation and skillful use of magnetic minerals also stimulates one to draw cross-cultural parallels. The evidence and analysis offered in this article provide a basis for hypotheses of parallel cultural developments in China and the Olmec New World. If the Olmec did discover the geomagnetic orienting properties of lodestone, as did the Han Chinese, it is most reasonable to speculate that they would have used their compass for comparable geomantic purposes. It should, however, be recognized that the Olmec claim, if documented, predates the Chinese discovery of the geomagnetic lodestone compass by more than a millennium. At present, M-160 is a unique artifact and San Lorenzo a unique site: "The first civilized center of Mesoamerica and probably of the New World" (19, p. 89). Further documentation of the Olmec claim must await the discovery of similar artifacts in museums, private collections, or as yet undiscovered Olmec sites. I would welcome communications from anyone possessing information relating to such artifacts. Regardless of shape, purposefully grooved and highly polished specimens of magnetic minerals are of particular interest. It would also be useful for the archeologist excavating Olmec burials and offerings to carefully note their alignments and consider them in a geomantic context. In addition to the discovery of supporting artifacts, establishment of Olmec primacy of the lodestone compass depends on the acquisition of the archeomagnetic data for the Early Formative period. I appeal to archeologists who find good archeomagnetic samples (burned hearths and post-holes) from the Formative periods to convey this information to R. DuBois of the University of Oklahoma. In a few years, the archeomagnetic data should be available for the last three millennia and the possibilities are very exciting.  相似文献   
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In situ measurements of the composition and spatial distribution of heavy thermal positive ions in the coma of comet Halley were made with the heavy-ion analyzer RPA2-PICCA aboard the Giotto spacecraft. Above 50 atomic mass units an ordered series of mass peaks centered at 61, 75, 91, and 105 atomic mass units were observed. Each peak appears to be composed of three or more closely spaced masses. The abundances decrease and the dissociation rates increase smoothly with increasing mass. These observations suggest the presence of chain molecules that are enriched in carbon, oxygen, and hydrogen, such as polyoxymethylene (polymerized formaldehyde), in comet Halley.  相似文献   
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Stratospheric temperatures on Saturn imply a strong decay of the equatorial winds with altitude. If the decrease in winds reported from recent Hubble Space Telescope images is not a temporal change, then the features tracked must have been at least 130 kilometers higher than in earlier studies. Saturn's south polar stratosphere is warmer than predicted from simple radiative models. The C/H ratio on Saturn is seven times solar, twice Jupiter's. Saturn's ring temperatures have radial variations down to the smallest scale resolved (100 kilometers). Diurnal surface temperature variations on Phoebe suggest a more porous regolith than on the jovian satellites.  相似文献   
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