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排序方式: 共有822条查询结果,搜索用时 24 毫秒
51.
Thorleifsson G Magnusson KP Sulem P Walters GB Gudbjartsson DF Stefansson H Jonsson T Jonasdottir A Jonasdottir A Stefansdottir G Masson G Hardarson GA Petursson H Arnarsson A Motallebipour M Wallerman O Wadelius C Gulcher JR Thorsteinsdottir U Kong A Jonasson F Stefansson K 《Science (New York, N.Y.)》2007,317(5843):1397-1400
Glaucoma is a leading cause of irreversible blindness. A genome-wide search yielded multiple single-nucleotide polymorphisms (SNPs) in the 15q24.1 region associated with glaucoma. Further investigation revealed that the association is confined to exfoliation glaucoma (XFG). Two nonsynonymous SNPs in exon 1 of the gene LOXL1 explain the association, and the data suggest that they confer risk of XFG mainly through exfoliation syndrome (XFS). About 25% of the general population is homozygous for the highest-risk haplotype, and their risk of suffering from XFG is more than 100 times that of individuals carrying only low-risk haplotypes. The population-attributable risk is more than 99%. The product of LOXL1 catalyzes the formation of elastin fibers found to be a major component of the lesions in XFG. 相似文献
52.
Inhibition of cytotoxicity of lymphocytes by concanavalin A in vitro 总被引:10,自引:0,他引:10
Human lymphocytes treated with the plant protein concanavalin A are stimulated to transform into blasts, without developing cytotoxicity for chicken erythrocytes. Prior treatment of lymphocytes with concanavalin A potentiated phytohemagglutinin-induced blast transformation and DNA synthesis but completely inhibited phytohemagglutinin-induced cytotoxicity. Inhibiton was not due to suppression of the mixed lymphocyte-erythrocyte aggregation normally caused by phytohemagglutinin. Inhibition of cytotoxicity was reversible when concanavalin A was removed from the lymphocytes by treatment with methyl-alpha-D-manno-pyranoside after 1 hour but not after 20 hours. The results indicate that blast transformation and cytotoxicity are separate expressions of lymphocyte stimulation. 相似文献
53.
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing 总被引:1,自引:0,他引:1
Maeda S Hsu LC Liu H Bankston LA Iimura M Kagnoff MF Eckmann L Karin M 《Science (New York, N.Y.)》2005,307(5710):734-738
Variants of NOD2, an intracellular sensor of bacteria-derived muramyl dipeptide (MDP), increase susceptibility to Crohn's disease (CD). These variants are thought to be defective in activation of nuclear factor kappaB (NF-kappaB) and antibacterial defenses, but CD clinical specimens display elevated NF-kappaB activity. To illuminate the pathophysiological function of NOD2, we introduced such a variant to the mouse Nod2 locus. Mutant mice exhibited elevated NF-kappaB activation in response to MDP and more efficient processing and secretion of the cytokine interleukin-1beta (IL-1beta). These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion. 相似文献
54.
Fire-derived charcoal causes loss of forest humus 总被引:5,自引:0,他引:5
Fire is a global driver of carbon storage and converts a substantial proportion of plant biomass to black carbon (for example, charcoal), which remains in the soil for thousands of years. Black carbon is therefore often proposed as an important long-term sink of soil carbon. We ran a 10-year experiment in each of three boreal forest stands to show that fire-derived charcoal promotes loss of forest humus and that this is associated with enhancement of microbial activity by charcoal. This result shows that charcoal-induced losses of belowground carbon in forests can partially offset the benefits of charcoal as a long-term carbon sink. 相似文献
55.
56.
Baerlocher C Gramm F Massüger L McCusker LB He Z Hovmöller S Zou X 《Science (New York, N.Y.)》2007,315(5815):1113-1116
Despite substantial advances in crystal structure determination methodology for polycrystalline materials, some problems have remained intractable. A case in point is the zeolite catalyst IM-5, whose structure has eluded determination for almost 10 years. Here we present a charge-flipping structure-solution algorithm, extended to facilitate the combined use of powder diffraction and electron microscopy data. With this algorithm, we have elucidated the complex structure of IM-5, with 24 topologically distinct silicon atoms and an unusual two-dimensional medium-pore channel system. This powerful approach to structure solution can be applied without modification to any type of polycrystalline material (e.g., catalysts, ceramics, pharmaceuticals, complex metal alloys) and is therefore pertinent to a diverse range of scientific disciplines. 相似文献
57.
El-Sayed NM Myler PJ Blandin G Berriman M Crabtree J Aggarwal G Caler E Renauld H Worthey EA Hertz-Fowler C Ghedin E Peacock C Bartholomeu DC Haas BJ Tran AN Wortman JR Alsmark UC Angiuoli S Anupama A Badger J Bringaud F Cadag E Carlton JM Cerqueira GC Creasy T Delcher AL Djikeng A Embley TM Hauser C Ivens AC Kummerfeld SK Pereira-Leal JB Nilsson D Peterson J Salzberg SL Shallom J Silva JC Sundaram J Westenberger S White O Melville SE Donelson JE Andersson B Stuart KD Hall N 《Science (New York, N.Y.)》2005,309(5733):404-409
A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont. 相似文献
58.
To analyze the dynamics of protein complexes during the yeast cell cycle, we integrated data on protein interactions and gene expression. The resulting time-dependent interaction network places both periodically and constitutively expressed proteins in a temporal cell cycle context, thereby revealing previously unknown components and modules. We discovered that most complexes consist of both periodically and constitutively expressed subunits, which suggests that the former control complex activity by a mechanism of just-in-time assembly. Consistent with this, we show that additional regulation through targeted degradation and phosphorylation by Cdc28p (Cdk1) specifically affects the periodically expressed proteins. 相似文献
59.
A global overview of dam-based impacts on large river systems shows that over half (172 out of 292) are affected by dams, including the eight most biogeographically diverse. Dam-impacted catchments experience higher irrigation pressure and about 25 times more economic activity per unit of water than do unaffected catchments. In view of projected changes in climate and water resource use, these findings can be used to identify ecological risks associated with further impacts on large river systems. 相似文献
60.
Matts Lindbladh Adam Felton Renats Trubins Ola Sallnäs 《European Journal of Forest Research》2011,130(5):861-869
As resources allocated specifically for conservation are limited, there is a need to ensure conservation policy initiatives
lead to effective conservation outcomes. In this study, we investigated the potential conservation benefits from alternative
spatial allocations of old deciduous stands to a landscape dominated by coniferous production forests owned primarily by non-industrial
private forest owners. As a target species, we used the long-tailed tit (Aegithalos caudatus), a species associated with deciduous forests and known to be sensitive to isolation. We used a previously published model
based on empirical data on the occurrence of this species, to assess the probability of occurrence of the bird in a 4,000 km2 area in southern Sweden for which we possess detailed spatial GIS data (kNN data) of tree species composition and age. We
assessed alternative scenarios where old deciduous forest was allocated with or without respect to distance from existing
old deciduous forests. Due to the long-tailed tit’s habitat requirement increasing the amount of old deciduous forests close
to existing habitats was the most effective strategy. However, the potential advantages of this strategy may in fact be overturned
in favor of the other scenarios if ownership structures and probable uptake rates of policy initiatives are also considered.
If a policy initiative is targeted toward owners with properties in close proximity to existing suitable habitat, when compared
to if all forest owners are targeted, a higher proportion of owners is needed to participate in order to achieve the same
degree of habitat creation for the species. Here, we discuss the potential benefits for effective conservation policy formulation
from integrating spatially explicit datasets and detailed ecological knowledge with land-ownership structures and policy uptake
scenarios. 相似文献