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排序方式: 共有502条查询结果,搜索用时 281 毫秒
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Adrian Boswood Sonya G. Gordon Jens Häggström Martin Vanselow Gerhard Wess Rebecca L. Stepien Mark A. Oyama Bruce W. Keene John Bonagura Kristin A. MacDonald Mark Patteson Sarah Smith Philip R. Fox Karen Sanderson Richard Woolley Viktor Szatmári Pierre Menaut Whitney M. Church M. Lynne O'Sullivan Jean-Philippe Jaudon Jan-Gerd Kresken John Rush Kirstie A. Barrett Steven L. Rosenthal Ashley B. Saunders Ingrid Ljungvall Michael Deinert Eric Bomassi Amara H. Estrada Maria J. Fernandez Del Palacio N. Sydney Moise Jonathan A. Abbott Yoko Fujii Alan Spier Michael W. Luethy Roberto A. Santilli Masami Uechi Anna Tidholm Christoph Schummer Philip Watson 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(3):1108-1118
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Peeraporn Varinthra Shun-Ping Huang Supin Chompoopong Zhi-Hong Wen Ingrid Y. Liu 《Marine drugs》2021,19(1)
Age-related macular degeneration (AMD) is a progressive eye disease that causes irreversible impairment of central vision, and effective treatment is not yet available. Extracellular accumulation of amyloid-beta (Aβ) in drusen that lie under the retinal pigment epithelium (RPE) has been reported as one of the early signs of AMD and was found in more than 60% of Alzheimer’s disease (AD) patients. Extracellular deposition of Aβ can induce the expression of inflammatory cytokines such as IL-1β, TNF-α, COX-2, and iNOS in RPE cells. Thus, finding a compound that can effectively reduce the inflammatory response may help the treatment of AMD. In this research, we investigated the anti-inflammatory effect of the coral-derived compound 4-(phenylsulfanyl) butan-2-one (4-PSB-2) on Aβ1-42 oligomer (oAβ1-42) added to the human adult retinal pigment epithelial cell line (ARPE-19). Our results demonstrated that 4-PSB-2 can decrease the elevated expressions of TNF-α, COX-2, and iNOS via NF-κB signaling in ARPE-19 cells treated with oAβ1-42 without causing any cytotoxicity or notable side effects. This study suggests that 4-PSB-2 is a promising drug candidate for attenuation of AMD. 相似文献
94.
Evaluation of DRAINMOD using saturated hydraulic conductivity estimated by a pedotransfer function model 总被引:1,自引:0,他引:1
Direct measurement of soil saturated hydraulic conductivity (Ks) is time-consuming and therefore costly. The ROSETTA pedotransfer function model is able to estimate Ks from soil textural data, bulk density and one or two water retention points. This study evaluated the feasibility of running the DRAINMOD field-scale hydrological model with Ks input produced using ROSETTA. A hierarchical approach was adopted to estimate Ks using ROSETTA, with four limited-more extended sets of soil information used as inputs: USDA textural class (H1); texture (H2); texture and bulk density (H3); texture, bulk density, water retention at −33 kPa (θ33 kPa) and −1500 kPa (θ1500 kPa) (H4). ROSETTA-estimated Ks values from these four groups (H1-H4) were used in DRAINMOD to simulate drain outflows during a 4-year period from a conventional drainage plot (CD) and two controlled drainage plots (CWT1 and CWT2) located in south-east Sweden. The DRAINMOD results using ROSETTA-estimated Ks values were compared with observed values and with model results using laboratory-measured Ks values (H0). Deviations in simulated drainage outflow (D), infiltration (F) and evapotranspiration (ET) resulting from the use of ROSETTA-estimated rather than laboratory-measured Ks values were evaluated. During the study period, statistical comparisons showed good agreement on a monthly basis between observed and DRAINMOD-simulated drainage rates using five soil datasets (H0, H1, H2, H3 and H4). The monthly mean absolute error (MAE) ranged from 0.57 to 0.82 cm for CD, 0.38 to 0.41 cm for CWT1, and 0.15 to 0.22 cm for CWT2. On a monthly basis, the modified coefficient efficiency (E′) values were in the range of 0.62 to 0.74 for CD, 0.72 to 0.74 for CWT1, and 0.79 to 0.86 for CWT2. The modified index of agreement (d′) for monthly predictions ranged from 0.80 to 0.86 cm for CD, 0.87 to 0.88 cm for CWT1, and 0.89 to 0.93 cm for CWT2. The absolute values of the percent-normalised error (NE) on an overall basis when using ROSETTA-estimated rather than laboratory-measured Ks values were less than 3% in E, less than 1% in F, and less than 15% in D. The results suggest that ROSETTA-estimated Ks values can be used in DRAINMOD to simulate drainage outflows as accurately as laboratory-measured Ks values (H0) in coarse-textured soils. 相似文献
95.
Ingrid Allgoewer DVM Susanne Lucas DVM Stephan Albert Schmitz MD 《Veterinary radiology & ultrasound》2000,41(5):413-418
The magnetic resonance imaging appearance of the feline middle ear is described in three healthy cats and in five cats with middle ear disease. Owing to the good spatial resolution, multiplanar slice orientation as well as display high contrast resolution of soft tissue, in particular fluids, MR imaging was helpful prior to surgery. It is superior to radiography which failed to allow identification of the abnormality in two of our five cats. MR imaging for middle ear disease should include dorsal and transverse plane images using T1- and T2-weighted sequences. In the presence of a mass within the bulla or the external ear canal application of contrast medium is helpful. 相似文献
96.
Vineyard evaluation of stilbenoid‐rich grape cane extracts against downy mildew: a large‐scale study
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Description and Biomechanical Comparison of a Percutaneous Radiologic Gastropexy Technique in a Canine Cadaver Model 下载免费PDF全文