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[目的] 研究结石通片对小鼠的急性毒性作用,对健康大鼠的利尿作用,以及对乙二酰胺致大鼠肾结石的调节作用。[方法] 取ICR小鼠40只,雌、雄各半,随机分为对照组与给药组,每组20只,观察结石通片给药前后小鼠的体重变化和死亡情况;另取SD大鼠36只,雌、雄各半,分为对照组、低剂量组(给予5%结石通片溶液)和高剂量组(给予10%结石通片溶液),统计各组大鼠24 h排尿量;并采用42只雄性SD大鼠,考查结石通片对给予乙二酰胺(2%掺喂)后大鼠体重、肾重和肾重比的影响。[结果] 给予结石通片溶液后,连续观察7 d,小鼠的各项生理活动未见明显异常,给药组与对照组相比体重差异不显著(P>0.05);与对照组比较,给予结石通片溶液后大鼠24 h内排尿量明显增加(P<0.01);与对照组比较,给药组随着给药剂量的增加,结晶和结石的数量极显著(P<0.01或P<0.001)减少,形成结石的动物数量极显著(P<0.01或P<0.001)减少。[结论] 结石通片对小鼠无明显急性毒性作用,对大鼠利尿作用明显,并对乙二酰胺致大鼠肾结石具有明显抑制作用。 相似文献
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对紫外-可见分光光度法测定阿苯达唑片含量的不确定度进行评定以及测量过程中各种不确定度来源进行分析与评估,含量测定结果可表示为(95.7±2.0)%(k=2)。结果表明,仪器的吸光度、重量差异、称样量和移液管的体积引入的不确定度为测量结果不确定度的主要影响因素。 相似文献
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为完善银翘片质量标准,采用高效液相色谱法对银翘片中牛蒡苷的含量测定进行了研究。色谱柱为C18(4.6mm×250mm,5μm),流动相为乙腈-0.1%冰乙酸溶液(25:75),检测波长为280nm,流速1mL/min,柱温25℃,进样量10μL。牛蒡苷进样浓度在0.1~2mg/mL范围内与峰面积呈良好的线性关系(r=0.9999);样品平均回收率为96.5%(n=6),RSD为1.3%。本方法简便、准确度高、重复性好,为进一步控制银翘片的质量提供了依据。 相似文献
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本文是在原味奶片的基础上添加了草莓粉、草莓香精、柠檬酸和食用色素等原料,并通过单因素实验、正交实验和感官评定的方法确定草莓奶片的最佳产品配方。结果表明最佳配方参数为草莓果粉添加量为20‰、草莓香精添加量为3.5‰、柠檬酸添加量5.0‰、食用色素添加量0.0025‰。 相似文献
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AIM: To study the dynamic expression of protease-activated receptors-1 (PAR-1) after intracerebral hemorrhage (ICH) and the influence of Nao Xue Kang Tablet (NXKT) on it's expression. METHODS: 72 Wistar rats were divided into normal group, ICH model groups (ICH, 6 h, 24 h, 3 d, 7 d), Nao Xue Kang groups (NXKT, 6 h, 24 h, 3 d,7 d). ICH models were produced with the induction of collagenase typeⅦ-S, except normal group. Immunohistochemical method was used to detect PAR-1 protein and RT-PCR technique was used to detect PAR-1 mRNA in brain tissues around the haematoma at different time points of different groups. RESULTS: PAR-1 protein and mRNA were mildly positive in normal group. In ICH model groups, intensity of PAR-1 expression started to increase at 6 h, and further increased at 24 h. PAR-1 expression reached the peak at 3 d and began to descend. At 7 d the decent was obvious. At 6 h, 24 h, 3 d, and 7 d time points, the PAR-1 protein positive cell number and PAR-1 mRNA absorbance ratio in ICH model and NXKT groups were significantly higher than those in normal group (P<0.05 or P<0.01). The PAR-1 protein positive cell number and PAR-1 mRNA absorbance ratio in NXKT group were significantly lower than in ICH model group (P<0.05 or P<0.01). CONCLUSION: After ICH, PAR-1 is continuously activated because of the stimulation of thrombin. Action of thrombin after ICH may be mediated by PAR-1; NXKT may inhibit the activation of PAR-1, so the praxiology is improved. This may be one of the main mechanisms that NXKT could facilitate the recovery of nervous function. 相似文献
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To examine the rate of chemical weathering, field experiments using microweight-loss techniques were carried out. Two kinds of porous rhyolite forming lava domes in Kozu-shima Island were selected: (1) a younger rock (weathering period is 2.6 ka) and (2) an older rock (20 ka). Both rocks seem to have been very similar in their initial composition and structure. They have, however, different properties in the present depending on the difference in weathering period. Rock tablets of these rhyolites with a diameter of 3.5 cm and a thickness of about 1 cm were enclosed in a nylon mesh bag and placed in a soil–bedrock interface on a hillslope of central Japan for over 5 years. The younger rock has a lower weight loss by about 0.5%, and the older rock has a higher weight loss of 3% to 5%. These results show that older rock has a higher rate of chemical weathering than in younger rock. This supports Oguchi et al.'s (Oguchi, T.C., Hatta, T., Matsukura, Y., 1994. Changes in rock properties of porous rhyolite through 40,000 years in Kozu-shima Island, Japan. Geogr. Rev. Jpn. 67A, 775–793 (in Japanese, with English Abstr.); Oguchi, T.C., Hatta, T., Matsukura, Y., 1999. Weathering rates over 40,000 years based on changes in rock properties of porous rhyolite. Phys. Chem. Earth (A) 24, 861–870.) finding that the rate of change in chemical properties appears to accelerate with weathering time. 相似文献
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本试验以康思农蜂胶片为材料对动物进行食品安全性毒理学试验,采用霍恩氏法对试验动物小鼠进行急性毒性试验,采用Ames法,对小鼠进行遗传毒性试验。试验结果表明,康思农蜂胶片属实际无毒级。未见任何遗传性毒性作用。 相似文献
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为了以藏灵菇为发酵剂研制出新型片剂乳制食品,该文通过口味正交试验确定了藏灵菇益生菌奶片的最佳制作工艺配方,其配方的质量分数分别为10%脱脂藏灵菇奶冻干粉+40%全脂奶粉+14%白砂糖粉+2.5%硬脂酸镁+2.5%羧甲基纤维素钠(CMC-Na)+31%脱脂奶粉。通过电子鼻检测不同配比的脱脂藏灵菇益生菌奶片,绘制线性判别分析(LDA)图,客观地描述了脱脂(包括不同评分)和全脂藏灵菇益生菌奶片在LDA图上的分布区域。藏灵菇益生菌奶片的初始乳酸菌总数对数值为9.26,经过120 d的4℃保存,乳酸菌总数对数值为7.41,满足市售要求。将藏灵菇和脱脂藏灵菇奶片的扫描电镜图进行比较展示了其结构以及内部菌种的分布。综合成本和品质分析,认为藏灵菇益生菌奶片的生产可行性强。 相似文献