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Acetylcholinesterase-Inhibiting Activity of Pyrrole Derivatives from a Novel Marine Gliding Bacterium, Rapidithrix thailandica
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Yutthapong Sangnoi Oraphan Sakulkeo Supreeya Yuenyongsawad Akkharawit Kanjana-opas Kornkanok Ingkaninan Anuchit Plubrukarn Khanit Suwanborirux 《Marine drugs》2008,6(4):578-586
Acetylcholinesterase-inhibiting activity of marinoquinoline A (1), a new pyrroloquinoline from a novel species of a marine gliding bacterium Rapidithrix thailandica, was assessed (IC50 4.9 μM). Two related pyrrole derivatives, 3-(2′-aminophenyl)-pyrrole (3) and 2,2-dimethyl-pyrrolo-1,2-dihydroquinoline (4), were also isolated from two other strains of R. thailandica. The isolation of 3 from a natural source is reported here for the first time. Compound 4 was proposed to be an isolation artifact derived from 3. The two isolated compounds were virtually inactive in the acetylcholinesterase-inhibitory assay (enzyme inhibition < 30% at 0.1 g L−1). 相似文献
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Snow forces impede afforestation in the subalpine region; in particular juvenescent trees can be damaged by extraction from the ground. Such forces are mainly triggered by intense snow gliding which is a frequent phenomenon on slopes with a smooth ground surface. 相似文献
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