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Polymethylmethacrylate orbital implants with interconnecting channels. A retrospective study following enucleation in dogs and cats
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Kazuhiro Shiozaki Momo Shiozaki Junko Masuda Akiko Yamauchi Shuichi Ohwada Toshiki Nakano Toshiyasu Yamaguchi Tadao Saito Koji Muramoto Minoru Sato 《Fisheries Science》2010,76(5):865-872
Angiotensin-I-converting enzyme (ACE) plays a crucial role in the crisis of hypertension. Some peptides that originate from
protease hydrolysates are known to suppress ACE activity in vitro and in vivo. Here, we investigated whether trypsin hydrolysate
of oyster Crassostrea gigas showed hypotensive activity and ACE inhibition. The hydrolysate significantly suppressed systolic blood pressure and ACE
activity in spontaneously hypertensive rats following a one-shot oral administration and a long-term feeding experiment lasting
9 weeks. Each hydrolysate from oyster tissue showed ACE inhibitory activity, indicating the hypotensive effect was due to
synergism. One potent ACE inhibitory peptide, Asp-Leu-Thr-Asp-Tyr, was identified from the hydrolysate of the striate muscle,
and the peptide exhibited hypotensive activity in vivo. Protease digestion analysis suggested that Asp-Tyr could be the real
effector of this penta-peptide in vivo. 相似文献
3.
Jin DH Zhang Y Suzuki Y Naganuma T Ogawa T Hatakeyama E Muramoto K 《Journal of agricultural and food chemistry》2000,48(11):5450-5454
Protein hydrolysates, prepared by enzymatic digestion of soybean protein and egg white albumin using several proteases, inhibited the crystal growth of calcium carbonate. Each hydrolysate showed different inhibitory activities, suggesting the key role of peptide structures in the inhibition. The deamidation of protein hydrolysates by glutaminase increased not only the inhibitory activity toward the crystal growth of calcium carbonate but also the resistance of the hydrolysates against peptic digestion. Furthermore, the addition of sodium chloride, citric acid, or lactose into the reaction mixture enhanced the inhibitory activity. The protein hydrolysates inhibited both nucleation and crystal growth of calcium carbonate and also affected the crystal morphology. 相似文献
4.
Sex-chromosome chimerism (XX-XY) in heterosexual bovine triplets 总被引:3,自引:0,他引:3
H Kanagawa K Kawata T Ishikawa J Muramoto H Ono 《The Japanese journal of veterinary research》1965,13(4):121-126
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Cotton RG Auerbach AD Axton M Barash CI Berkovic SF Brookes AJ Burn J Cutting G den Dunnen JT Flicek P Freimer N Greenblatt MS Howard HJ Katz M Macrae FA Maglott D Möslein G Povey S Ramesar RS Richards CS Seminara D Smith TD Sobrido MJ Solbakk JH Tanzi RE Tavtigian SV Taylor GR Utsunomiya J Watson M 《Science (New York, N.Y.)》2008,322(5903):861-862
An ambitious plan to collect, curate, and make accessible information on genetic variations affecting human health is beginning to be realized. 相似文献
8.
Akira Watanabe Kazunari Kinoshita Takayuki Muramoto Mizuho Nakai Yuiko Suzuki Sakumi Inoue Shigeki Hirata 《Animal Science Journal》2021,92(1):e13602
Colorimetric pH strips (MColorpHast™) are very convenient to use, but the decision of pH is based on an individual's color perception and is, therefore, subjective. We developed a pH calculation program for the image of coloring strips on CIE1976 (L*a*b* color space), which slightly underestimated human judgment as the color of pH darker. This image analysis and three individuals' judgments were used for evaluating the strip's features for various qualities of meat from wild animals, and the results were compared with the assessments based on potentiometric pH. In both methods, dipping the strips in distilled water just before use improved the regression coefficient compared with that mentioned in the manual. The image analysis showed higher correlation than human judgments but slightly underestimate pH by a maximum of 0.13 unit from the regression line of the potentiometric pH. In addition, the image analysis revealed meat pigment changed pH higher on the color scale in the lower meat pH region. The strips must be used according to the manual, but dipping is effective when the meat surface is dry, and keeping the strips from touching the meat drip is important in lower pH region because the pigment affects the color of pH. 相似文献
9.
Antioxidative properties of tripeptide libraries prepared by the combinatorial chemistry 总被引:11,自引:0,他引:11
Saito K Jin DH Ogawa T Muramoto K Hatakeyama E Yasuhara T Nokihara K 《Journal of agricultural and food chemistry》2003,51(12):3668-3674
Two series of combinatorial tripeptide libraries were constructed, based on an antioxidative peptide isolated from a soybean protein hydrolysate. One was a library of 108 peptides containing either His or Tyr residues. Another was a library of 114 peptides related to Pro-His-His, which had been identified as an active core of the antioxidative peptide. The antioxidative properties of these libraries were examined by several methods, such as the antioxidative activity against the peroxidation of linoleic acid, the reducing activity, the radical scavenging activity, and the peroxynitrite scavenging activity. Two Tyr-containg tripeptides showed higher activities than those of two His-containing tripeptides in the peroxidation of linoleic acid. Tyr-His-Tyr showed a strong synergistic effects with phenolic antioxidants. However, the tripeptide had only marginal reducing activity and a moderate peroxynitrite scavenging activity. Cysteine-containing tripeptides showed the strong peroxynitrite scavenging activity. Change of either the N-terminus or C-terminus of Pro-His-His to other amino acid residues did not significantly alter their antioxidative activity. Tripeptides containing Trp or Tyr residues at the C-terminus had strong radical scavenging activities, but very weak peroxynitrite scavenging activity. The present results allow us to understand why protein digests have such a variety of antioxidative properties. 相似文献
10.
Yasuharu Watanabe Yin-Hsuan Chang Osamu Nakamura Takako Naganuma Tomohisa Ogawa Koji Muramoto 《Fisheries Science》2013,79(3):513-519
Rhamnose-binding lectins (RBLs) have been isolated and characterized from various kinds of fish. RBLs recognize the structures of lipopolysaccharides and lipoteichoic acid on microbes, and have an opsonic effect, suggesting that RBLs play an important role as pattern recognition proteins in innate immunity. However, the function of RBLs in the removal of pathogens from the body has not yet been elucidated. In this study, we investigated the effect of three RBLs—named CSL1, 2, and 3—that were isolated from chum salmon Oncorhynchus keta eggs on the respiratory burst activity in a macrophage cell line. The CSLs induced reactive oxygen species in the peritoneal macrophage cell line from rainbow trout Oncorhynchus mykiss (RTM5). However, this activity was not affected by l-rhamnose or dl-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol, an inhibitor for glucosylceramide synthesis, indicating that the interaction between CSLs and Gb3 on cell surfaces was not involved in the induction of respiratory burst activity. 相似文献