共查询到20条相似文献,搜索用时 78 毫秒
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为探索牛寄生虫药物驱虫效果,筛选高效驱虫药物组合,新晃县畜牧水产局在省市的指导下,在新晃县境内的兴隆、禾滩二个乡镇分5个组,进行牛药物驱虫筛选试验。结果表明:牛驱虫药物组合从驱虫、增重效果来看,以吡喹酮+虫克星为最佳,硫双二氯酚+虫克星次之。但因吡喹酮药物昂贵,从经济的角度出发,可将硫双二氯酚+虫克星作为大面积牛驱虫的优选药物组合。 相似文献
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《中国畜牧兽医文摘》2016,(7)
为了研究几种药物的驱虫效果以及药物对山羊生产的影响,分别对阿苯达唑50mg/kg;依维菌素注射液0.2 mg/kg;吡喹酮片50 mg/kg;以上三种药物进行驱虫试验。实验结果表明:驱虫羊的增重速度显著高于不驱虫羊;从增重效果来看,以阿苯达为最佳,驱虫效果最佳的是伊维菌素,因此,建议龙里县选择阿苯达+伊维菌素驱虫药物组合进行大面积推广。 相似文献
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综述了大环内酯类抗寄生虫药物美贝霉素肟的理化性质、药效学、药动学、临床应用、安全性和应用展望。该药对内寄生虫和外寄生虫均有效,抗虫机制独特,广谱抗虫、高效。作为专用于宠物临床的抗寄生虫药,美贝霉素肟价格低廉,极具临床推广价值,具有广阔的应用前景。 相似文献
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Sanchez Bruni SF Jones DG McKellar QA 《Journal of veterinary pharmacology and therapeutics》2006,29(6):443-457
Parasitic diseases are an important health concern to small animal veterinarians worldwide, and their zoonotic potential is also of relevance to human medicine. The treatment and control of such conditions relies heavily on pharmaceutical intervention using a range of antiparasitic drugs and/or their biologically active metabolites. Broad spectrum agents have been produced, although narrow and even monospecific drugs are used in some situations. Their efficacy may depend on dosage, the target pathogen(s), the host species and/or the site of infection. Optimal use of antiparasitics requires a detailed consideration of the pharmacokinetic and pharmacodynamic properties of the drugs in specific clinical contexts. This review summarizes the present status of knowledge on the metabolism, and physicochemical and pharmacological properties of the major antiparasitic drugs currently used in small animal veterinary practice. In addition, data relevant to therapeutic dosage, efficacy and clinical indication/contraindication, particularly in relation to combination drug therapy, are included. 相似文献
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为分析不同驱虫药对感染豆状囊尾蚴肌肉营养成分含量的影响,本试验采用3种抗蠕虫药(甲苯咪唑、吡喹酮、丙硫苯咪唑)对人工感染豆状囊尾蚴家兔进行驱虫试验,并对感染豆状囊尾蚴后和驱虫后家兔肌肉营养成分(水分、灰分、脂肪和蛋白质)含量变化进行分析。结果表明,3种抗蠕虫药对家兔感染豆状囊尾蚴均有不同程度的驱虫效果,家兔肌肉营养成分含量有不同程度的升高。其中,甲苯咪唑和丙硫苯咪唑对家兔肌肉中的水分、脂肪和蛋白质含量影响较大,吡喹酮驱虫后家兔肌肉中灰分含量增加较明显。 相似文献
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Swan GE 《Journal of the South African Veterinary Association》1999,70(2):61-70
The halogenated salicylanilides are a large group of compounds developed mainly for their antiparasitic activity in animals. Several halogenated salicylanilides with potent antiparasitic activity have been synthesised of which only closantel, niclosamide, oxyclozanide, rafoxanide and resorantel are commercially available. Closantel and rafoxanide, which represent the most important drugs in the group, are used extensively for the control of Haemonchus spp. and Fasciola spp. infestations in sheep and cattle and Oestrus ovis in sheep in many parts of the world. Niclosamide is used extensively for its anticestodal activity in a wide range of animals. Antiparasitic activity of the halogenated salicylanilides has also been demonstrated against a large number of other internal parasites, in particular haematophagous helminths, and external parasites including ticks and mites, in a variety of animal species. Several cases of toxicity and mortality have been reported for closantel and rafoxanide in sheep and goats. Their unique pharmacokinetic behaviour appears to play an important role in the efficacy and safety of these compounds. The chemical and physical characteristics, mode of action, pharmacokinetics, antiparasitic activity and toxicity of the halogenated salicylanilides in animals are reviewed. 相似文献
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Recent publications dealing mainly with the kinetics of antiparasitic and antibacterial agents, NSAIDs, and other drugs in camels are briefly reviewed. The kinetic data for most of these drugs indicated that they have longer absorption and elimination half-lives and slower systemic clearance in the camel compared to other animals. This corroborates earlier reports that suggested that the activities of drug-metabolizing enzymes and the capacity to biotransform and eliminate xenobiotics is lower in camels than in other ruminants. There is a clear need to establish basic kinetic data for the camel in order to avoid extrapolation of drug dosage regimens and withdrawal times from data for other animals, as this may result in irrational use of drugs in camels. 相似文献
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Managing parasiticide resistance 总被引:3,自引:0,他引:3
Sangster NC 《Veterinary parasitology》2001,98(1-3):89-109
Resistance to antiparasitic drugs is all too common in parasites of veterinary interest. The fact that resistance has arisen in so many different species of parasite and hosts against so many different drugs and in so many geographic areas suggests that the resistances may have common features. Such features may be useful in generating ideas for resistance management. Although describing the nature and presence of resistance remains an important objective, there is now a pressing need to develop improved methods of detection of resistance and to devise schemes for integrated parasite management (IPM). Multidisciplinary teams of researchers and extension workers are exploring new ways to deal with the problem of resistance. 相似文献
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B. H. Ali 《Veterinary research communications》1988,12(1):67-75
Specific recommendations for drug dosages for the camel are rare and doses for this species are usually extrapolated from those recommended for other species. The pharmacology and toxicity of drugs likely to be used in the camel needs to be further studied to ensure the efficacy and safety of these drugs in this species.Most of the reported work is on the chemotherapeutic efficacy of a few drugs long in use in other species against trypanosomiasis, mange and gastrointestinal nematodes. Areas of study most deficient are pharmacodynamics, pharmacokinetics and drug metabolism. The anatomical, physiological and biochemical peculiarities of the camel warrant more pharmacological and toxicological studies in this species.This article surveys the literature on the pharmacology, toxicity and therapeutic uses of some antiparasitic and antibacterial drugs and central nervous system depressants commonly used in the camel. It appears that camels are more susceptible to the toxic action of some trypanocidal drugs than other species. In certain cases they may metabolize some drugs differently. In general, the camel appears to be a good subject for analgesics and anaesthetics. 相似文献
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M. Wierup C. Löwenhielm M. Wold-Troell I. Agenäs 《Veterinary research communications》1987,11(5):397-405
The total animal consumption of antibiotic and chemotherapeutic drugs in Sweden during 1980, 1982 and 1984 has been studied. The study also included coccidiostatic, antiparasitic and antimycotic drugs. The total animal consumption during the years mentioned was 66.1, 68.8 and 72.6 tons of active substance, respectively, and the amount of antibacterial drugs for therapy was 28.7 (43.4%), 29.1 (42.5%) and 34.1 (47.0%) tons, respectively. Tetracycline, penicillin, sulphonamide and aminoglycoside were the four major groups of antibiotics used for therapy of bacterial infections in animals. The consumption was related to the metabolic bodyweights of animals which were the potential consumers. A comparison was also made with the corresponding human consumption during 1980. The data on antibiotic consumption can be divided by county and compared to the animal population and disease situation in each county. This study thus offers a good base for further investigations on different aspects of the use of antibiotics. 相似文献
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Müntener CR Bruckner L Gassner B Stürer A Demuth DC Althaus FR Zwahlen R 《Schweizer Archiv für Tierheilkunde》2007,149(10):439-448
We received 190 reports of suspected adverse events (SARs) following the use of veterinary drugs for the year 2006: 118 declarations for veterinary drugs and 72 declarations following the application of immunolgical medicinal products. Most of the 118 declarations relate to the use of antiparasitic drugs (48%) and every second declaration to drug use in dogs. Other drug classes concerned were, in decreasing order, antiinfectives (20%) and drugs used off-label (12%; other target species or other indication). For the vaccines, most of the reactions occurred in dogs (62%) followed by horses (11%) and cattle (10%). The most frequently reported reactions concerned the use of a vaccine against piroplasmosis. Another 349 requests for information were processed by the Swiss Toxicological Information center. We also present a case of a serious adverse reaction in form of a Stevens-Johnson syndrome in a cat as well as a case of ketamine abuse. We note the growing interest of practicing veterinarians with pleasure and are currently working on further adaptations to the system. 相似文献