共查询到20条相似文献,搜索用时 125 毫秒
2.
微孢子虫是一类专营细胞内寄生的真核生物,它是一种关系到农业生产和人类健康的病原微生物。本文主要针对国内外有关应用多菌灵、夫马洁林、阿苯哒唑等药剂对微孢子虫病的研究进展进行了综述,希望为微粒子病的化学治疗提供新思路。 相似文献
4.
5.
<正>隐孢子虫是动物常见的机会致病性原虫,对哺乳动物主要引起以腹泻为主要症状的隐孢子虫病。随着人们生活水平的提高,兔作为经济动物和宠物与人类的关系日益密切,逐渐融入到人类的日常生活中,在部分地区发挥着很重要的作用。但近年来研究发现,兔可传播流行性人兽共患肠道寄生虫病,防治不及时就会对人类的健康造成很大的威胁。 相似文献
6.
隐孢子虫病(Cryptosxporidiosis)是一种全球性的人畜共患病。现已发现隐抱子虫可寄生于多种脊椎动物,其中包括哺乳动物、乌类、爬行类和鱼类。隐强子虫属于真球虫目、隐抱科、隐抱属,目前认为其有效种有6个,即感染鱼类的鼻隐抱子虫(C.nasorum)、感染爬行类的响尾蛇隐抱子虫(C.crotatN、感染鸟类的火鸡隐抱子虫(C。meleagrZdZs)和贝氏隐梅子虫(C.baileyi)、感染哺乳动物的鼠隐抱子虫(C。。urZs)和小隐掴寸一虫(C.parvu。)。下面就其引起的局部病理变化、兔疫器官的反应。免疫反应和免疫诊断等方面综述之。】.寄生… 相似文献
7.
8.
隐孢子虫病免疫学研究进展 总被引:2,自引:0,他引:2
隐孢子虫病(Cryptosporidiosis)是一种全球性的人畜共患病。其病原体为一种寄生性原虫,即隐孢子虫。隐孢子虫属于真球虫目、隐孢科、隐孢属,目前认为其有效种有6个,即感染鱼类的鼻隐抱子虫(C.nasorum)、感染爬行类的响尾蛇隐池子虫(C.crotati)、感染鸟类的火鸡隐抱子虫(C.meleagridis)和贝氏隐抱子虫(C.baileyi)、感染哺乳动物的鼠隐抱子虫(C.muris)和小隐子虫(C.parvum)。现已发现隐抱子虫可寄生于多种脊椎动物,下面就其引起的局部病理变化、免疫器官的反应、免疫反应和免疫诊断等方面述之。1寄生部位与所引起… 相似文献
9.
10.
本文叙述了国内外学者研究蜜蜂微孢子虫病的成果,包括:蜜蜂微孢子虫(Nosema apis)的生物学,发育周期,孢子虫病的流行规律及影响发病的因素,患病蜜的病理及孢子虫病的诊断防治。 相似文献
11.
运用透射电镜术、原位末端标记技术(TUNEL)和流式细胞术对11只自然感染兔脑炎原虫獭兔的肾脏进行了细胞凋亡研究,5只健康长耳白兔用作对照。结果表明.凋亡细胞多见于远曲小管和集合管的上皮细胞。用透射电镜观察,初期的凋亡细胞,其细胞核的染色质高度凝集,边缘化,粗面内质网增多、扩张呈泡状;后期的凋亡细胞,其细胞质浓缩.细胞膜起泡,细胞核分裂成块状,最后形成膜包裹的凋亡小体。TUNEL法检测,病变轻微的细胞,胞核微缩,胞膜增厚;病变严重的细胞,其胞核体积明显缩小,胞膜皱缩,最后形成膜包裹的凋亡小体。流式细胞术检测,病兔可呈现明显的亚“G1”峰,凋亡细胞百分比与对照兔相比差异极显著(P=0.01),且病兔。肾细胞的周期也有所改变。结果表明,3种方法检测的病兔肾上皮细胞凋亡数均高于对照免。 相似文献
12.
为了有效地治疗兔脑炎原虫病,本研究根据脑炎原虫的生物学特点和对组织损伤的特征选用阿苯达唑进行了治疗试验。将28只3~4月龄隐性感染的獭兔,随机分为对照组和治疗组进行试验。治疗组按30mg/kg剂量(首次给药量为50mg/kg),每隔12h给药1次,连续用药10d,停药1周为1个治疗期,共治疗3个疗程。对照组按正常饲养。每1疗程之后,均采血和尿液进行ELISA检测和尿沉渣虫体检查。结果,治疗组的病兔用阿苯达唑治疗3个疗程后,ELISA检测的D值均低于标准值(〈0.044),即抗脑炎原虫血清抗体呈阴性反应,从尿沉渣中也不能检出虫体。而对照组病免的D值则大大高于正常值.从尿沉渣中均易检出虫,并有1只对照兔出现典型的神经症状,剖检后从脑组织中检出脑炎原虫性肉芽肿。经方差分析,2组间差异非常显著(P〈0.01)。试验证明,阿苯达唑对兔脑炎原虫有良好治疗作用,用药的时机以脑炎原虫还未进入脑组织时最合适,用药的剂量一定要保持有效的杀虫浓度。 相似文献
13.
用在体外连续培养10代的兔脑炎原虫,接种于12只家兔,动态地观察了脑炎原虫对家免的感染情况。实验发现,肾脏产生的病变明显早于大脑,即感染3周后,用Gram's和Goodpasture's染色,即可在髓袢和远曲小管内脱落的上皮细胞中发现兔脑炎原虫。6周后即可见到间质性肾炎变化,而脑组织于感染9~12周时才见有细胞性肉芽肿的形成;脑炎原虫具有较强的抗原性,即在感染3周后,血液中的抗体含量足以进行诊断。 相似文献
14.
15.
16.
17.
Inge Bjerks 《Acta veterinaria Scandinavica》1990,31(4):423-432
Central nervous system lesions were studied by light microscopy in 43 farmed mink, aged 5 months to 2 1/2 years, with spontaneous encephalitozoonosis and showing cataractous eye changes. Lesions were found in the brain and spinal cord of all animals examined but were generally mild and chronic. The lesions were consistent with those previously described in spontaneous encephalitozoonosis in other carnivores. Parasites in parasitophorous vacuoles and free or phagocytosed in necrotic and granulomatous lesions were demonstrated in animals aged 5 months to 1 year. The occurrence of arterial lesions of the polyarteritis nodosa type found in the youngest animals probably indicates fetal infection. In animals aged 1 1/2 and 2 1/2 years active lesions were usually lacking and the changes were characterized by arterial sclerosis, sometimes with aneurysmal formations, small perivascular lympho-plasmacytic cuffings and focal gliosis. 相似文献
18.
Newborn and young pups up to the age of 15 days were exposed to E. cuniculi, either by keeping the pups in cages together with orally inoculated foster-mothers and their offspring, or by oral inoculation with E. cuniculi spores. A majority of pups appeared sero-positive to E. cuniculi with the india-ink immuno-reaction from 35 to 87 days post exposure; spores of E. cuniculi were detected in organs of some of the animals. The non-inoculated pups kept together with the orally inoculated pups became seropositive from 49 to 129 days after the oral inoculations. However, the exposure of newborn and young pups failed to induce clinical encephalitozoo-nosis, and when killed at the time of pelting the body weights and fur quality appeared to be within the normal range in all exposed foxes. No macroscopic lesions were detected in the various organs. Histologically focal interstitial nephritis occurred in the great majority of the seropositive animals. Meningoencephalitis was seen in some of the foxes, whereas slightly thickened walls of some arteries, mainly in the myocardium, were found in a few animals. The lesions of the brain and kidneys seem to be very similar to those seen in chronic cases of rabbit encephalitozoonosis. Polyarteritis nodosa and severe encephalitis and interstitial nephritis with extensive proliferations of plasma cells, which are almost constant findings in cases of clinically diseased foxes, were not detected in any of the subclinically infected animals. Various factors that might be of significance in the pathogenesis of the disease are discussed, and it is concluded that intrauterine infection of the pups via the transplacental route appears to be an essential supposition for the establishment of clinical fox encephalitozoonosis. 相似文献
19.
Spores of Encephalitozoon cuniculi were recovered from foetal and placental tissues from blue fox females orally inoculated with the parasite. The results provided evidence for transplacental transmission of the causative agent of fox encephalitozoonosis. 相似文献
20.
Svein Fredrik Mohn 《Acta veterinaria Scandinavica》1982,23(4):503
Two groups of blue fox pups about 1½— 2 and 2½—3 months old, respectively, suffering from experimental encephalitozoonosis, were examined clinically and serologically. Antibodies to Encephalitozoon cuniouli were detected in all pups, the titres varying within the range 10–12,800. In addition to unspecific signs of disease the pups showed various neurological disturbances including ataxia, posterior weakness, lameness and circling behaviour, terminaiting in recumbency, paralysis or convulsions. Reduced sight or blindness was observed occasionally. Some of the pups appeared thirsty. Haematological examinations revealed pronounced leukocytosis without any conspicuous shift within the various groups of leukocytes. Biochemical examinations of serum showed significant elevated values of urea nitrogen, creatinine, and magnesium concentrations, reflecting renal dysfunction. Alanine aminotransferase was found significantly depressed in both groups. Raised levels of total protein were demonstrated due to pronounced hyperglobulinaemia. This finding, together with the common occurrence of generalized polyarteritis nodosa and proliferations of plasma cells in clinically affected pups, is probably a result of autoimmune disturbances initiated directly or indirectly by the protozoan infection. 相似文献