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免疫促进剂是一类用来增进机体免疫应答、调节免疫功能、维持机体免疫功能相对稳定,以达到防治疾病目的的物质。在动物医学上的应用将具有重要价值和作用。本文概述了家禽免疫促进剂的研究现状及其作用机理,并展望其应用前景。 相似文献
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1免疫促进剂
中医免疫学中指出中草药中补气、补血、补阴、补阳等药材,对低下的免疫反应有促进作用,能提高机体免疫系统的功能,增强机体的免疫力,促进免疫反应向着有利于机体的方面进行,达到治愈疾病的目的。凡具有上述作用的中药,都可称为中药免疫促进剂。 相似文献
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动物免疫促进剂的应用 总被引:1,自引:0,他引:1
扈留轩 《兽药与饲料添加剂》2001,6(5):17-18
动物机体接种疫苗后产生主动免疫的原理是十分复杂的,它受动物机体自身免疫系统和接种疫苗的免疫原性两方面影响,其中动物机体自身的健全状况属内因,是起决定作用的。近几年来动物免疫促进剂在畜禽疾病防治中的研究与应用日益引起国内外的重视,本文对能提高动物机体免疫力的物质的应用作一介绍。动物免疫促进剂指的是在疫苗接种前后或与疫苗同时应用,可使有效免疫应答反应及早出现,持续时间延长,免疫应答反应幅度提高,增强机体抗病力的物质。免疫促进剂的作用机理是通过作用于淋巴细胞膜受体,提高细胞中环磷酸腺苷和环磷酸鸟苷的水… 相似文献
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免疫增强剂-紫锥菊的研究进展 总被引:1,自引:0,他引:1
免疫增强剂是指能增强机体免疫功能的物质,亦称免疫促进剂,是近些年来出现的一类新型生物活性制剂.过去多为化学合成物质,因其存在副作用,因而在应用上受到限制. 相似文献
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刘晓跃 《畜牧兽医科技信息》2019,(9)
正免疫增强剂又称免疫促进剂及免疫刺激剂。这类药物能激活一种或多种免疫活性细胞,增强机体特异性和非特异性免疫共能,使底下的免疫功能恢复正常,或具有佐剂作用,或替代体内缺乏的免疫活性成分发挥作用。免疫增强剂可以增强鸡群的免疫力,有效避免鸡群受病原体感染,还可以保障饲养人员的身体健康,提高疫病防治 相似文献
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动物接种疫苗后,产生主动免疫的原理是十分复杂的,它受动物机体自身免疫系统和接种疫苗的免疫原性两方面影响,其中动物机体自身的健康状况属内因,是起决定作用的。近几年来动物免疫促进剂在畜禽疾病防治的研究与应用日益引起国内外的熏视,本文对能提高动物机体免疫力的物质的应用作一介绍。 相似文献
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免疫增强剂在鸡疫病防制中的应用 总被引:2,自引:1,他引:1
随着现代化养鸡业集约化程度的不断提高,鸡场的疫病防御愈发重要。疫苗的应用已被广大养殖业者充分认可,在鸡疫病防制中起到了不可替代的作用。但是因各种原因,疫苗在疫病防制中并不能发挥最大的免疫保护效力。免疫增强剂自发现以来,已经在人及各种动物的疾病防治中得以广泛尝试应用。研究证明,免疫增强剂与疫苗的联合应用,取得了较好的免疫增强效果,提高了疫苗对动物机体的保护效率,因而对于免疫增强剂的研究已成为当代免疫学研究的热点之一。为了在临床中更好的应用免疫增强剂,提高疫苗效力,现将一些免疫增强剂在鸡疫病防制中的应用做一综述。 相似文献
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干扰素是一种诱生性糖蛋白,有抗病毒、抗肿瘤与免疫调节等多种生物学作用.当畜禽感染病毒时,干扰素是最先发挥作用的抵抗分子.干扰素参与早期黏膜免疫并通过产生一系列与免疫调节相关的细胞因子来活化机体的天然免疫与适应性免疫应答从而使机体处于抗病毒状态.干扰素因其重要的生物学功能,在流行性病毒病防治的应用中越来越广泛.本文从不同... 相似文献
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Shirasuna K Kawashima C Murayama C Aoki Y Masuda Y Kida K Matsui M Shimizu T Miyamoto A 《The Journal of reproduction and development》2011,57(1):135-142
The decrease in fertility and conception rates of high-producing dairy cows is one of the major negative impacts for today's producers. The recovery of ovarian activity postpartum is affected by the status of immunity, metabolism and reproduction and plays a critical role in subsequent fertility after parturition in the cow. In the present study we investigated the relationships between polymorphisms in genes relating to the above functions and the first postpartum ovulation as a marker of the recovery of ovarian function in the cow. In immune function related-factors, the occurrence of first postpartum ovulation within 3 weeks in the C/C genotypes of tumor necrosis factor α (TNFα) exon (55.4%) and the A/G genotypes of TNFα promoter (55.4%) was significantly higher than that in T/T genotypes of TNFα exon (14.3%) and A/A genotypes of TNFα promoter (14.3%). Moreover, anovulatory cows with the T/T genotype of TNFα exon and the A/A genotype of TNFα promoter tended to have a prolonged days open compared with those of the other genotypes of TNFα polymorphisms. In metabolic function-related factors, ovulatory and anovulatory cows had a different distribution for alleles of the growth hormone receptor, but there were no significant differences in genotype and allele frequency of insulin-like growth factor-I polymorphism. No significant relationships were found between ovarian function after parturition and polymorphisms for reproduction-related genes. In conclusion, polymorphisms of TNFα gene both in exon and promoter regions have a strong association with the early first ovulation within 3 weeks after parturition in the high-producing dairy cow. Taken together, polymorphisms of TNFα gene could be strongly related to early first ovulation after parturition, thus being an effective tool of selection for improving reproductive performance in the high-producing dairy cow. 相似文献
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Marlene Paibomesai Brendan Hussey Maria Nino-Soto Bonnie A. Mallard 《Canadian journal of veterinary research》2013,77(1):54-62
This study investigated epigenetic mechanisms by which DNA methylation affects the function of bovine adaptive immune system cells, particularly during the peripartum period, when shifts in type 1 and type 2 immune response (IR) biases are thought to occur. Stimulation of CD4+ T-lymphocytes isolated from 5 Holstein dairy cows before and after parturition with concanavalin A (ConA) and stimulation of CD4+ T-lymphocytes isolated from 3 Holstein dairy cows in mid-lactation with ConA alone or ConA plus dexamethasone (Dex) had significant effects on production of the cytokines interferon gamma (IFN-γ, type 1) and interleukin 4 (IL-4, type 2) that were consistent with DNA methylation profiles of the IFN-γ gene promoter region but not consistent for the IL-4 promoter region. ConA stimulation increased the production of both cytokines before and after parturition. It decreased DNA methylation in the IFN-γ promoter region but increased for IL-4 promoter region. Parturition was associated with an increase in IFN-γ production in ConA-stimulated cells that approached significance. Overall, DNA methylation in both promoter regions increased between the prepartum and postpartum periods, although this did not correlate with secreted cytokine concentrations. Dexamethasone treated cells acted in a manner consistent with the glucocorticoid’s immunosuppressive activity, which mimicked the change at the IFN-γ promoter region observed during parturition. These results support pregnancy as type 2 IR biased, with increases of IFN-γ occurring after parturition and an increase in IL-4 production before calving. It is likely that these changes may be epigenetically controlled. 相似文献