THIAMBUTENE AND ACEPROMAZINE AS ANALGESIC AND PREANESTHETIC AGENTS IN HORSES AND SHEEP

Investigations into the analgesic effect of thiambutene and its value as a pre-anaesthetic agent were carried out in the horse and the sheep. Special emphasis was placed on the post-anaesthetic recovery period.
Thiambutene produced analgesia in both species. Toxic effects such as muscle tremor and hyperkinesia occurred with high doses. Prior administration of acepromazine increased the tolerated doses of thiambutene, and satisfactory neuroleptanalgesic states were produced.
Combined use of thiambutene and acepromazine in pre-anaesthetic medication reduced the dose of thiopentone required for anaesthesia in both species and significantly improved post-anaesthetic recovery.
Administration of nalorphine in both species reduced the duration of the recovery period. In the horse, even after prolonged thiopentone anaesthesia, nalorphine produced a shorter, quieter recovery.
It was concluded that pre-anaesthetic medication with thiambutene and acepromazine facilitated thiopentone anaesthesia and greatly reduced the problems of post-anaesthetic recovery in horses.     

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