共查询到20条相似文献,搜索用时 31 毫秒
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Mechanisms of glyphosate resistance and response to alternative herbicide‐based management in populations of the three Conyza species introduced in southern Spain 下载免费PDF全文
Ignacio Amaro‐Blanco Pablo Tomás Fernández‐Moreno María Dolores Osuna‐Ruiz Fernando Bastida Rafael De Prado 《Pest management science》2018,74(8):1925-1937
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Intensive herbicide use has selected for constitutively elevated levels of stress‐responsive mRNAs and proteins in multiple herbicide‐resistant Avena fatua L 下载免费PDF全文
Barbara K Keith Erin E Burns Brian Bothner Charles C Carey Aurélien J Mazurie Jonathan K Hilmer Sezgi Biyiklioglu Hikmet Budak William E Dyer 《Pest management science》2017,73(11):2267-2281
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Jonathan Gressel 《Pest management science》2020,76(2):421-425
For many years, the emphasis of industry discovery programs has been on finding new target sites of pesticides and finding pesticides that inhibit single targets. There had been an emphasis on genomics in finding single targets for potential pesticides. There is also the claim that registration of single target inhibiting pesticides is simpler if the mode of action is known. Conversely, if one looks at the evolution of resistance from an epidemiological perspective to ascertain which pesticides have been the most recalcitrant to evolutionary forces, it is those that have multiple target sites of action. Non‐target‐site resistances can evolve to multi‐target‐site inhibitors, but these resistances can often be overcome by structural modification of the pesticide. Industry has looked at pest‐toxic natural products as pesticide leads, but seems to have abandoned those where they can find no single target of action. Perhaps nature has been intelligent and evolved many natural products that are synergistic multi‐target‐site inhibitors, and that is why natural compounds have been active for millennia? We should be learning from nature while combining new chemistry technologies with vast accrued databases and computer aided design allowing fragment‐based discovery and scaffold hopping to produce multi‐target site inhibitors instead of single target pesticides. © 2019 Society of Chemical Industry 相似文献
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