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Cocaine addiction: psychology and neurophysiology   总被引:30,自引:0,他引:30  
F H Gawin 《Science (New York, N.Y.)》1991,251(5001):1580-1586
Cocaine was considered incapable of producing dependence in 1980 but was recently proclaimed the drug of greatest national health concern. Recent clinical and preclinical investigations demonstrate that cocaine produces unique abuse and withdrawal patterns that differ from those of other major abused drugs and suggest that long-term cocaine abuse produces neurophysiological alterations in specific systems in the central nervous system that regulate the capacity to experience pleasure. It will be necessary to develop clinically pertinent research models before these findings can be considered definitive, but these evolving ideas have already led to applications of promising experimental treatments for cocaine abuse.  相似文献   

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通过对彩色马蹄莲(Zantedeschia Pink Persuasion)的盆栽萌发试验,发现芽的直径约为0.7 cm或大于0.7 cm,芽高约为0.3 cm或大于0.3 cm时,具有优先萌发的优势,称其为"优势芽".芽体高度和直径可以作为判断彩色马蹄莲球茎优劣的一个依据.  相似文献   

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RAZRAN G 《Science (New York, N.Y.)》1958,128(3333):1187-1194
Pavlov's experiments, begun long before the revolution, have always been generously supported by the Soviet state. However, their far-reaching ontological and methodological implication gained an official and commanding position to Soviet biomedical and psychosocial (as distinct from socioeconomic) sciences only in 1950 with the Resolution of the 28 June-4 July Joint Pavlovian Session of the Soviet Academy of Sciences and Academy of Medical Sciences. In the biomedical sciences, present-day Soviet Pavlovianism may best be conceived of as (i) a doctrine of nervism (a Russian term)-the ubiquity of neural control of bodily reactions (neural, neurosomatic, neurovisceral, and neurohumoral) and (ii) a doctrine of what might be called concomitantism (my term )-the ready and radical modification of these reactions by concomitant reactions; or, viewed more generally and somewhat differently, as (iii) a far-reaching physicalistic psychosomaticism or, rather, a neuroviscerosomaticism. Psychophysiology-or higher nervous activity-is the key discipline here. With scores of research institutes, it is indeed a very well-established, wide-scoped, and faradvanced faradvanced science that, in both present achievements and future capabilities, is a challenge to American and Western equivalents. On the other hand, in the psychosocial sciences and the key discipline of psychology proper, unmitigated Pavlovian physicalism and objectivism is met head on by (i) the unbending postulate of dialectical materialism of "the specific emergent efficacy of consciousness and subjective conscious categories" as well as by (ii) the simple consideration that a consistent Pavlovianism is a fully autarchic psychology and needs no other science of psychology on top of it. A large portion of current Soviet psychological theory in psychology proper is thus primarily a textual and exegetic collation and conciliation of the views of Pavlov with those of Marx, Engels, and Lenin (until recently and, to some extent even now, also of Stalin), just as most current Soviet psychological experimentation in psychology proper is primarily a duplication of what Soviet psychophysiology could do as well, if not better. Moreover, there is the longstanding drastic ban on intelligence testing, psychoanalysis, Gestalt psychology, and other to-be-shunned "bourgeois-psychological" thought-and-practice systems, so that, in all, psychology proper is a much constricted and, per se, more ancilliary than basic discipline of Soviet empirical research-a state of affairs plainly reflected in the fact that the number of its research institutes and publications (as well as the number of psychologists proper) is but a small fraction of the number in psychophysiology. Yet, in evaluating our efforts in the area vis-à-vis those of the Soviets, we must, obviously, take full account of both disciplines, Soviet psychophysiology being in all respects a psychology in American terms (60). Indeed, it is Soviet psychophysiology, and not Soviet psychology proper, that is the homolog not only of American behavioristics but also, to a large extent, of all American experimental psychology.  相似文献   

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通过选择性试验和非选择性试验,研究了马缨丹5种溶剂萃取物和氯仿萃取物不同浓度对美洲斑潜蝇成虫的产卵驱避作用和拒食作用,结果表明,低极性萃取物和高极性萃取物对美洲斑潜蝇都有一定的产卵驱避作用和拒食作用,其中氯仿萃取物的产卵驱避作用和拒食作用最强,其干扰作用控制指数和拒食率分别为0.370、0.230和59.699%、47.882%,马缨丹氯仿萃取物对美洲斑潜蝇成虫的产卵驱避作用和拒食作用随浓度的增大而增强。  相似文献   

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