| 副溶血性弧菌Ⅲ型分泌系统与Ⅵ型分泌系统的研究进展 |
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| 引用本文： | 刘海泉,江春铃,赵伟,钱江,潘迎捷,胡金庆,赵勇.副溶血性弧菌Ⅲ型分泌系统与Ⅵ型分泌系统的研究进展[J].上海海洋大学学报,2023,32(3):660-668. |
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| 作者姓名： | 刘海泉 江春铃 赵伟 钱江 潘迎捷 胡金庆 赵勇 |
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| 作者单位： | 上海海洋大学 食品学院,上海海洋大学 食品学院,上海海洋大学 食品学院,上海海洋大学 食品学院,上海海洋大学 食品学院,上海海洋大学,上海海洋大学 食品学院 |
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| 基金项目： | 国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 摘 要： | 副溶血性弧菌（Vibrio parahaemolyticus，VP）是一种常见的革兰氏阴性细菌，主要分布在海洋、海口和河口沉积物中，能够引起人急性肠胃炎、伤口感染和败血症，同时危害水产品养殖业。由该菌引起的食物中毒事件在全世界范围内频繁发生，该菌被认为是微生物性食物中毒的主要病原菌之一。影响副溶血性弧菌致病性的毒力因素包括溶血素、黏附因子、分泌系统等，尤其在分泌系统中，Ⅲ型分泌系统（Type Ⅲ Secretion Systems,T3SS）和Ⅵ型分泌系统（T6SS）与副溶血性弧菌致病性密切相关。T3SS是一种多亚基针状结构，将分泌蛋白通过供体细胞质直接注入受体细胞质；T6SS是一种接触依赖性蛋白分泌装置，将毒素直接注入目标细胞内。通过对Ⅲ型分泌系统和Ⅵ型分泌系统的研究进展进行梳理，从这两种分泌系统的结构出发，并对其功能和调控机制上分别进行了分析比较，指出了这二者在效应蛋白及产生毒素上的不同，找出了二者与副溶血性弧菌定植的关系，以期通过这两者的联系进而深入了解副溶血性弧菌的致病机制，为防治该菌提供科学的指导。
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| 关 键 词： | Ⅲ型分泌系统 Ⅵ型分泌系统 副溶血性弧菌 致病性 |
| 收稿时间： | 2022/2/22 0:00:00 |
| 修稿时间： | 2022/8/25 0:00:00 |
Study on the role of type III secretion system and type VI secretion system of Vibrio parahaemolyticus |
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| LIU Haiquan,JIANG Chunling,ZHAO Wei,QIAN Jiang,PAN Yingjie,HU Jinqing,ZHAO Yong.Study on the role of type III secretion system and type VI secretion system of Vibrio parahaemolyticus[J].Journal of Shanghai Ocean University,2023,32(3):660-668. |
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| Authors: | LIU Haiquan JIANG Chunling ZHAO Wei QIAN Jiang PAN Yingjie HU Jinqing ZHAO Yong |
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| Affiliation: | Shanghai Ocean University,Shanghai Ocean University,Shanghai Ocean University,Shanghai Ocean University,Shanghai Ocean University,Shanghai Ocean University,Shanghai Ocean University |
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| Abstract: | Vibrio parahaemolyticus(VP) is a common gram-negative bacteria, mainly distributed in marine, estuarine and estuarine sediments, which can cause acute gastroenteritis, wound infection and sepsis in humans, and endanger aquatic products Aquaculture. Food poisoning incidents caused by this bacterium occur frequently all over the world, and this bacterium is considered to be one of the main pathogens of microbial food poisoning. The virulence factors that affect the pathogenicity of VP include hemolysin, adhesion factor, secretion system, etc., especially in the secretion system, Type III Secretion Systems (T3SS) and Type VI Secretion Systems (T6SS) It is closely related to the pathogenicity of VP. T3SS is a multi-subunit needle-like structure that injects secreted proteins directly into the recipient cytoplasm through the donor cytoplasm; T6SS is a contact-dependent protein secretion apparatus that injects toxins directly into target cells. By sorting out the research progress of T3SS and T6SS, starting from the structure of these two secretion systems, and analyzing and comparing their functions and regulatory mechanisms, it is pointed out that the two are involved in effector proteins and regulatory mechanisms. The difference in the production of toxins, the relationship between the two and the colonization of VP was found out, in order to further understand the pathogenic mechanism of VP through the connection between the two, and provide scientific guidance for the prevention and treatment of the bacteria. |
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