| 加减苍附导痰汤对痰湿阻滞型非酒精性脂肪性肝病氧化应激水平及脂质代谢的影响 |
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| 作者姓名： | 万霞 万涛 |
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| 作者单位： | 湖北省荆州市中医医院, 湖北 荆州 434000,湖北省随州市中医医院, 湖北 随州 441300 |
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| 基金项目： | 荆州市科技局医疗卫生科技计划项目荆科技发（[2016]26-65）。 |
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| 摘 要： | 目的 观察加减苍附导痰汤对痰湿阻滞型非酒精性脂肪性肝病（non-alcoholicfattyliverdisease，NAFLD）氧化应激水平及脂质代谢的影响。方法 将82例痰湿阻滞型NAFLD患者随机分为治疗组42例和对照组40例。治疗组给予口服加减苍附导痰汤，对照组给予口服奥利司他胶囊，两组的疗程均为12周。观察两组患者治疗前后总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、血清丙氨酸氨基转移酶（ALT）、血清天冬氨酸氨基转移酶（AST）、丙二醛（MDA）、超氧化物歧化酶（SOD）水平、肝脏脂肪含量（LFC）及不良反应的发生情况。结果 治疗后两组患者TC、TG、LDL-C、HDL-C均较治疗前显著改善（P<0.05），且治疗组各项指标的改善优于对照组（P<0.05）；两组血清ALT、AST、MDA及LFC较治疗前明显降低，而血清SOD水平升高（P<0.05），且治疗组各项指标的改善优于对照组（P<0.05）。结论 加减苍附导痰汤对痰湿阻滞型NAFLD患者保肝降酶及降低肝脏脂肪含量有较好的疗效，可能与其提高抗氧化及脂质代谢水平有关。
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| 关 键 词： | 非酒精性脂肪性肝病 加减苍附导痰汤 氧化应激 脂质代谢 |
| 收稿时间： | 2018/8/28 0:00:00 |
Effects of Modified Cangfu Daotan Decoction on Oxidative Stress and Lipid Metabolism in Non-alcoholic Fatty Liver Disease with Syndrome of Phlegm-damp Obstruction |
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| Authors: | WAN Xia and WAN Tao |
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| Affiliation: | Jingzhou Hospital of Traditional Chinese Medicine, Jingzhou, Hubei 434000, China and Suizhou Hospital of Traditional Chinese Medicine, Suizhou, Hubei 441300, China |
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| Abstract: | Objective To observe the effects of modified Cangfu Daotan Decoction on lipid metabolism and oxidative stress level in non-alcoholic fatty liver disease (NAFLD) with syndrome of phlegm-damp obstruction. Methods A total of 82 patients of NAFLD with syndrome of phlegm-damp obstruction were randomly divided into treatment group with 42 cases and control group with 40 cases. The treatment group was treated with modified Cangfu Daotan Decoction orally and the control group was treated with Orlistat Capsules orally. The course of treatment was 12 weeks. The levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), malondialdehyde (MDA) and superoxide dismutase (SOD), liver fat content (LFC) and adverse reactions were observed before and after the treatment. Results After the treatment, the TC, TG, LDL-C and HDL-C of the 2 groups were significantly improved compared with those before the treatment (P<0.05), and the improvement of each index in the treatment group was better than that in the control group (P<0.05). The serum ALT, AST, MDA and LFC in the 2 groups were significantly decreased compared with those before the treatment, while serum SOD level was increased (P<0.05), and the improvement of each index in the treatment group was better than that in the control group (P<0.05). Conclusion There is good efficacy of modified Cangfu Daotan Decoction in NAFLD patients with syndrome of phlegm-damp obstruction to protect liver, reduce enzymes and liver fat content, which may be related to its improving anti-oxidation and lipid metabolism. |
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| Keywords: | non-alcoholic fatty liver disease modified Cangfu Daotan Decoction oxidative stress lipid metabolism |
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