| 一氧化氮供体型药物抗肿瘤作用的研究进展 |
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| 作者姓名： | 宾雨飞 廖端芳 |
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| 作者单位： | 湖南中医药大学药学院, 湖南 长沙 410208;湘产大宗药材品质评价湖南省重点实验室, 湖南 长沙 410208,湖南中医药大学药学院, 湖南 长沙 410208;湘产大宗药材品质评价湖南省重点实验室, 湖南 长沙 410208 |
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| 基金项目： | 湖南省自然科学基金（2015JJ6085） |
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| 摘 要： | 肿瘤已经成为当今社会的重大健康问题，作为抗肿瘤药物的一氧化氮（NO）供体型药物在这方面引人注目。一些NO供体药物已被证明具有良好的抗癌活性，显示出其应用潜力和价值。通过控制NO在适当的部位释放并杀死肿瘤细胞，实现药物的靶向性，是NO供体类药物治疗癌症的一个新领域和重要的发展方向。本文将综述NO供体型药物在抗肿瘤领域的研究进展，以及简要介绍新型NO供体纳米材料。
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| 关 键 词： | 肿瘤 NO供体型药物 新型NO供体纳米材料 |
| 收稿时间： | 2018/9/17 0:00:00 |
Progress in the Study of Anti-tumor Effect of Nitric Oxide Donor Drugs |
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| Authors: | BIN Yufei and LIAO Duanfang |
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| Affiliation: | School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Key Laboratory in Hunan Province for Quality Evaluation of Bulk Medicinal Materials from Hunan Province, Changsha, Hunan 410208, China and School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Key Laboratory in Hunan Province for Quality Evaluation of Bulk Medicinal Materials from Hunan Province, Changsha, Hunan 410208, China |
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| Abstract: | Tumor has become a major health problem in today''s society. As an anti-tumor drug, nitric oxide (NO) donor drug has attracted much attention in this field. Some NO donor drugs have shown good anti-cancer activity, showing their potential applications and value. It is a new field and an important development direction for NO donors to treat cancer by controlling the release of NO in appropriate sites and killing tumor cells, and then achieving drug targeting. This paper reviewed the research progress of NO donor drug-based drugs in the field of anti-tumor, and briefly introduce the new NO donor nanoparticle materials. |
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| Keywords: | tumor nitric oxide donor drugs new nitric oxide donor nanoparticle materials |
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