| 血浆miR-200c作为肺癌早期诊断的临床价值研究 |
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| 作者姓名： | 王瑛琨 贾冬冬 刘琼 窦宇红 徐志康 刘和录 |
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| 作者单位： | 广州医科大学附属深圳沙井人民医院检验科, 广东 深圳 518125,广州医科大学附属深圳沙井人民医院检验科, 广东 深圳 518125,广州医科大学附属深圳沙井人民医院检验科, 广东 深圳 518125,广州医科大学附属深圳沙井人民医院检验科, 广东 深圳 518125,广州医科大学附属深圳沙井人民医院检验科, 广东 深圳 518125,广州医科大学附属深圳沙井人民医院检验科, 广东 深圳 518125 |
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| 基金项目： | 深圳市宝安区科技创新局社会公益项目（2014208）。 |
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| 摘 要： | 目的 分析血浆miR-200c的表达与肺癌患者临床病理特征的相关性，并探讨miR-200c能否作为肺癌早期诊断的潜在肿瘤标志物的可能性。方法 收集55例肺癌患者和53例健康体检者，采用实时荧光定量PCR检测受检者血浆miR-200c的表达情况，对检测结果进行统计学分析。结果 miR-200c在肺癌患者组血浆中表达水平均高于正常对照组，差异有统计学意义（P<0.01）。受试者工作特征曲线显示miR-200c能够将肺癌与正常对照组区分出来（AUC=0.676）。结论 血浆miR-200c的表达可能与肺癌的发生有关，提示miR-200c可作为特异性生物标志物对肺癌患者进行早期诊断的可能性。
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| 关 键 词： | 肺癌 miR-200c 实时荧光定量PCR 早期诊断 |
| 收稿时间： | 2016/12/14 0:00:00 |
Clinical Value of Plasma miR-200c in Early Diagnosis of Lung Cancer |
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| Authors: | WANG Yingkun JIA Dongdong LIU Qiong DOU Yuhong XU Zhikang and LIU Helu |
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| Affiliation: | Clinical Laboratory, Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University, Shenzhen, Guangdong 518125, China,Clinical Laboratory, Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University, Shenzhen, Guangdong 518125, China,Clinical Laboratory, Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University, Shenzhen, Guangdong 518125, China,Clinical Laboratory, Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University, Shenzhen, Guangdong 518125, China,Clinical Laboratory, Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University, Shenzhen, Guangdong 518125, China and Clinical Laboratory, Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University, Shenzhen, Guangdong 518125, China |
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| Abstract: | Objective To analyze the correlation between plasma miR-200c expression and clinicopathological features of lung cancer patients,and to explore the possibility of miR-200c as a potential tumor marker for early diagnosis of lung cancer.Methods Fifty lung cancer patients and fifty-three healthy subjects,the expression of miR-200c in plasma was detected by real-time fluorescent quantitative PCR,and the results were statistically analyzed.Results MiR-200c expression in lung cancer patients were higher than that in normal control group and the difference was statistically significant (P<0.01).The receiver operating characteristic curve showed that miR-200c expression was able to differentiate lung cancer from the normal control group (AUC=0.676).Conclusion The expression of miR-200c in plasma may be related to the occurrence of lung cancer,suggesting that miR-200c may be a specific biomarker in patients during early diagnosis. |
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| Keywords: | lung cancer miR-200c real time PCR early diagnosis |
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