Extended‐spectrum beta‐lactamase‐producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru |
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| Authors: | J A Benavides C Shiva M Virhuez C Tello A Appelgren J Vendrell J Solassol D G Streicker |
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| Affiliation: | 1. Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK;2. Faculty of Veterinary Medicine and Zootechnics, University Cayetano Heredia of Peru, Lima, Peru;3. Association for the Conservation and Development of Natural Resources, Lima, Peru;4. Yunkawasi, Lima, Peru;5. Laboratoire de Bactériologie, Centre Hospitalier Universitaire (CHU) de Montpellier, Montpellier, France;6. MIVEGEC (Laboratoire Maladies Infectieuses et Vecteurs, Ecologie, Génétique, Evolution et Contr?le), UMR CNRS 5290/IRD 224, Université Montpellier, Montpellier, France;7. Department of Pathology, Arnaud de Villeneuve Hospital, CHU Montpellier, Montpellier, France |
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| Abstract: | Antibiotic resistance mediated by bacterial production of extended‐spectrum beta‐lactamase (ESBL) is a global threat to public health. ESBL resistance is most commonly hospital‐acquired; however, infections acquired outside of hospital settings have raised concerns over the role of livestock and wildlife in the zoonotic spread of ESBL‐producing bacteria. Only limited data are available on the circulation of ESBL‐producing bacteria in animals. Here, we report ESBL‐producing Escherichia coli in wild common vampire bats Desmodus rotundus and livestock near Lima, Peru. Molecular analyses revealed that most of this resistance resulted from the expression of blaCTX‐M‐15 genes carried by plasmids, which are disseminating worldwide in hospital settings and have also been observed in healthy children of Peru. Multilocus sequence typing showed a diverse pool of E. coli strains carrying this resistance that were not always host species‐specific, suggesting sharing of strains between species or infection from a common source. This study shows widespread ESBL resistance in wild and domestic animals, supporting animal communities as a potential source of resistance. Future work is needed to elucidate the role of bats in the dissemination of antibiotic‐resistant strains of public health importance and to understand the origin of the observed resistance. |
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| Keywords: | antibiotic resistance
Desmodus rotundus
ESBL‐producing Escherichia coli multilocus sequence typing Peru plasmid typing |
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