Effects of fatty acid transport protein 1 on proliferation and differentiation of porcine intramuscular preadipocytes |
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| Authors: | Xiaoling Chen Yanliu Luo Ruisheng Wang Bo Zhou Zhiqing Huang Gang Jia Hua Zhao Guangmang Liu |
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| Affiliation: | 1. Key Laboratory for Animal Disease‐Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, China;2. Chongqing Academy of Animal Sciences, Rongchang, China |
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| Abstract: | ![]()
Fatty acid transport protein 1 (FATP1) plays an important role in the fatty acid transmembrane transport and fat deposition. However, its role in porcine intramuscular preadipocytes proliferation and differentiation remain poorly understood. Here, we examined the effects of pFATP1 on porcine intramuscular preadipocytes proliferation and differentiation. Overexpression of pFATP1 in porcine intramuscular preadipocytes significantly promoted the proliferation of porcine intramuscular preadipocytes, and also significantly upregulated the expressions of peroxisome proliferator‐activated receptor γ, CCAAT enhancer binding protein α, lipoprotein lipase, fatty acid synthetase and perilipin 1. Moreover, overexpression of pFATP1 in porcine intramuscular preadipocytes significantly increased fat accumulation and downregulated β‐catenin protein expression. Overall, our results indicated that pFATP1 played an important role in porcine intramuscular preadipocytes proliferation and differentiation, and it might promote adipogenesis in porcine intramuscular preadipocytes by repressing Wnt/β‐catenin signaling pathway. |
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| Keywords: | differentiation porcine FATP1 porcine intramuscular preadipocytes proliferation |
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