Selenium‐enriched Saccharomyces cerevisiae improves growth,antioxidant status and selenoprotein gene expression in Arbor Acres broilers |
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| Authors: | F Chen L Zhu H Qiu S Qin |
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| Affiliation: | 1. Institute of Animal Nutritional and Metabolic Disorders, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China;2. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China;3. Department of Animal Science, Tianjin Agricultural University, Tianjin, China |
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| Abstract: | One hundred and fifty 7‐day‐old Arbor Acres broilers were randomly assigned into five groups: group 1 served as a control that was fed a basal diet without selenium (Se) supplementation; groups 2, 3 and 4 were fed the basal diet supplemented with 0.15, 0.5 and 1.5 mg Se as Se‐enriched Saccharomyces cerevisiae (SSC) per kg of diet; and group 5 was fed the basal diet supplemented with 0.15 mg per kg of Se as sodium selenite (SS). Growth performance, glutathione peroxidase (GPX) and superoxide dismutase (SOD) activities, total antioxidant capacity (T‐AOC), and malondialdehyde (MDA) content in plasma and liver, and cellular glutathione peroxidase (GPX‐1) and phospholipid hydroperoxide glutathione peroxidase (GPX‐4) mRNA levels in liver were determined. Compared with group 1, groups 2–4 exhibited higher body weights (p < 0.05), lower feed/gain ratios, and higher GPX activities in plasma (p < 0.05) and GPX and SOD activities and GPX‐1 and GPX‐4 mRNA levels in liver (p < 0.05). Compared with group 5, group 2 exhibited higher GPX activity in plasma on day 21 (p < 0.05). Compared with group 2 and 5, group 3 exhibited lower MDA content in plasma on day 7 (p < 0.05), higher GPX activity in plasma, SOD activity and GPX‐1 mRNA levels in liver on day 14 and 21 (p < 0.05), and higher GPX‐4 mRNA levels on day 14 (p < 0.05). Compared with group 4, group 3 exhibited lower MDA contents in plasma on day 14 (p < 0.05) and in liver on day 21 (p < 0.05), higher T‐AOC in plasma and higher GPX‐1 mRNA levels on day 14 and 21 (p < 0.05), and higher SOD activity in plasma and higher SOD and GPX activities in liver on day 21 (p < 0.05). Thus, SSC improves growth and antioxidant status of broilers; the short‐term bioavailability of SS was faster than that of SSC, but the long‐term bioavailability of SSC was greater than SS. |
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| Keywords: | average daily gain cellular glutathione peroxidase (GPX‐1) feed/gain ratio GPX activity phospholipid hydroperoxide glutathione peroxidase (GPX‐4) sodium selenite |
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