| 脾气虚证动物模型造模方法与模型评价的研究概述 |
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| 作者姓名： | 曾梅艳 陈雪莲 宋厚盼 陈小娟 陈新怡 赵沅 蔡雄 喻嵘 谢梦洲 |
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| 作者单位： | 湖南中医药大学中医诊断学湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学数字中医药协同创新中心, 湖南 长沙 410208;湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学医学院, 湖南 长沙 410208,湖南中医药大学中医诊断学湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学数字中医药协同创新中心, 湖南 长沙 410208;湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医诊断学湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学数字中医药协同创新中心, 湖南 长沙 410208;湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医诊断学湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学数字中医药协同创新中心, 湖南 长沙 410208;湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医诊断学湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学数字中医药协同创新中心, 湖南 长沙 410208;湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医诊断学湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学数字中医药协同创新中心, 湖南 长沙 410208;湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医诊断学湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学数字中医药协同创新中心, 湖南 长沙 410208 |
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| 基金项目： | 国家自然科学基金项目（81703920）；湖南省中医药管理局一般项目（201780）；湖南省大学生研究性学习和创新性实验计划项目（2017280） |
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| 摘 要： | 脾气虚证为临床常见的病证之一，证候动物模型是中医临床研究病因病机与疾病发展的基础，其中脾气虚证动物模型的建立对于脾胃病证的研究意义重大。在三十余年来的研究发展进程中，脾气虚证动物模型的构建经历了从单因素造模方法到复合因素造模方法的发展过程，研究取得一定成果的同时也暴露了一些问题。本文整理了脾气虚证动物模型的构建方法及模型评价方法，对其存在的问题进行探讨，以期为今后脾胃病的基础与临床研究提供参考。
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| 关 键 词： | 脾气虚证 动物模型 模型评价 |
| 收稿时间： | 2018/7/27 0:00:00 |
A Research Overview of Modeling Method and Model Evaluation for Animal Models of Spleen-Qi Deficiency Syndrome |
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| Authors: | ZENG Meiyan CHEN Xuelian SONG Houpan CHEN Xiaojuan CHEN Xinyi ZHAO Yuan CAI Xiong YU Rong and XIE Mengzhou |
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| Affiliation: | Hunan Provincial Key Laboratory of Diagnostics of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Cooperative Innovation Center of Digital Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,Hunan Provincial Key Laboratory of Diagnostics of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Cooperative Innovation Center of Digital Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,Hunan Provincial Key Laboratory of Diagnostics of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Cooperative Innovation Center of Digital Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,Hunan Provincial Key Laboratory of Diagnostics of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Cooperative Innovation Center of Digital Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,Hunan Provincial Key Laboratory of Diagnostics of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Cooperative Innovation Center of Digital Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,Hunan Provincial Key Laboratory of Diagnostics of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Cooperative Innovation Center of Digital Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China and Hunan Provincial Key Laboratory of Diagnostics of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Cooperative Innovation Center of Digital Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China |
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| Abstract: | Spleen-Qi deficiency syndrome is one of common clinical diseases and syndromes. Syndrome animal model is the foundation for clinical studies of etiology, pathogenesis, and disease progression in traditional Chinese medicine. The establishment of animal models of spleen-Qi deficiency syndrome is of great significance for the study of spleen-stomach diseases and syndromes. Over the past 30 years, the establishment of animal models of spleen-Qi deficiency syndrome has developed from single factor modeling to multiple factor modeling. These studies have achieved certain results and also exposed some problems at the same time. This article reviews the establishment method and model evaluation system for animal models of spleen-Qi deficiency syndrome and discusses the existing problems, so as to provide a reference for future basic and clinical research on spleen and stomach diseases. |
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| Keywords: | spleen-Qi deficiency syndrome animal model model evaluation |
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