| 美洲大蠊提取液保留灌肠治疗不确定性肠炎并发肛瘘术后的临床观察 |
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| 作者姓名： | 邓辉 杨敏 曾娟妮 |
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| 作者单位： | 娄星区人民医院, 湖南 娄底 417008,湖南中医药大学, 湖南 长沙 410208,湖南中医药大学第二附属医院, 湖南 长沙 410005 |
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| 基金项目： | 国家自然科学基金项目（81774325） |
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| 摘 要： | 目的 观察美洲大蠊提取液保留灌肠治疗不确定性肠炎并发肛瘘术后的临床疗效。方法 将30例不确定性肠炎并发肛瘘的患者随机分为治疗组、阳性对照组、空白对照组，每组10例，患者入院后行外科肛瘘切扩挂线术，术后行常规静脉抗炎、肠外营养、口服常规治疗药物等内科治疗，治疗组外用美洲大蠊提取液保留灌肠，阳性对照组外用结肠宁保留灌肠，空白对照组予以生理盐水安慰灌肠，15 d为1个疗程，连续治疗4个疗程。对比观察3组患者肛瘘术后创面面积、肠镜下结直肠黏膜水肿及溃疡情况，比较3组药物的临床疗效。结果 肛瘘术后创面面积比较，治疗组术后创面明显缩小，阳性对照组次之，空白对照组最差，差异均具有统计学意义（P<0.05）；肠镜下治疗组患者肠道黏膜水肿及溃疡数量明显少于阳性对照组及空白对照组，阳性对照组明显少于空白对照组，差异均具有统计学意义（P<0.05）。3组患者临床疗效比较，治疗组显效率为60.0%，明显高于阳性对照组的30.0%及空白对照组的10.0%（P<0.05）。结论 美洲大蠊提取液保留灌肠治疗不确定性肠炎并发肛瘘术后疗效显著，能缩小肛瘘创面，加速结肠炎症吸收，促进溃疡面愈合，为临床经济、高效的外用辅助治疗方法提供了理论基础。
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| 关 键 词： | 不确定性肠炎 肛瘘 美洲大蠊提取液 保留灌肠 |
| 收稿时间： | 2018/8/15 0:00:00 |
Clinical Effect of Retention Enema with Periplaneta americana Extract in Treatment of Uncertain Enteritis After Anal Fistula Surgery |
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| Authors: | DENG Hui YANG Min and ZENG Juanni |
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| Affiliation: | Louxing District People''s Hospital, Loudi, Hunan 417008, China,Hunan University of Chinese Medicine, Changsha, Hunan 410208, China and The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, China |
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| Abstract: | Objective To investigate the clinical effect of retention enema with Periplaneta americana extract in the treatment of uncertain enteritis after anal fistula surgery. Methods A total of 30 patients with uncertain enteritis complicated by anal fistula were randomly divided into treatment group, positive control group, and blank control group, with 10 patients in each group. All patients underwent cutting and thread-drawing surgery for anal fistula and were given routine medical treatment including intravenous anti-inflammatory therapy, parenteral nutrition, and oral administration of drugs. The patients in the treatment group were given retention enema with Periplaneta americana extract, those in the positive control group were given retention enema with Jiechangning, and those in the blank control group were given retention enema with normal saline. Each course of treatment was 15 days, and all patients were treated for 4 courses. The three groups were compared in terms of wound area after anal fistula surgery, colorectal mucosal edema and ulcer on colonoscopy, and clinical outcome after drug therapy. Results The treatment group had the most significant reduction in wound area after anal fistula surgery, followed by the positive control group and the blank control group (P<0.05). The treatment group had a significantly smaller amount of mucosal edema and ulcer on colonoscopy than the positive control group and the blank control group, and the positive control group had a significantly smaller amount than the blank control group (P<0.05). The treatment group had a significantly higher marked response rate than the positive control group and the blank control group (60.0% vs 30.0%/10.0%, P<0.05). Conclusion Retention enema with Periplaneta americana extract has a marked clinical effect in the treatment of uncertain enteritis after anal fistula surgery and can reduce the wound area of anal fistula, accelerate the absorption of colon inflammation, and promote ulcer healing, which provides a theoretical basis for economic and efficient external adjuvant therapy in clinical practice. |
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| Keywords: | uncertain enteritis anal fistula Periplaneta americana extract retention enema |
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