Plasma Vitamin D Metabolites and C‐Reactive Protein in Stage‐Stop Racing Endurance Sled Dogs |
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| Authors: | JW Spoo RL Downey C Griffitts RJ Horst CB Levine RM Childs JJ Wakshlag |
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| Affiliation: | 1. Best Care Pet Hospital, Sioux Falls, SD;2. Annamaet Petfoods, Sellersville, PA;3. The Traveling Vet, Loveland, CO;4. Heartland Assays, Ames, IA;5. Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY |
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| Abstract: | BackgroundDogs are a unique model for examining the effects of exercise on vitamin D status because of their lack of vitamin D synthesis by UV exposure. In addition, the inflammatory response may be associated with hypovitaminosis D.ObjectivesTo investigate the effects of several days of endurance exercise on plasma vitamin D (25‐(OH)D3, 24,25‐(OH)D3 and 1,25(OH)D3) and serum C‐reactive protein (CRP) concentrations in stage‐stop racing sled dogs.Animals12 racing sled dogs and 8 control dogs.MethodsBlood was collected before the race and immediately after racing on days 2 and 8. Plasma vitamin D metabolites and serum CRP concentrations were measured.ResultsRacing dogs showed a significant increase in 25(OH)D3 on day 2 (P = .027) and day 8 of the race (P < .001), whereas no increases were observed in control dogs. The plasma concentration of 24,25(OH)D3 showed a significant increase by day 8 (P < .001). There were no significant changes in 1,25(OH) D3 concentrations across all time points and groups. Racing dogs had significantly increased CRP concentrations by day 2 (39.3 ± 30.1 μg/mL; P < .001).Conclusions and Clinical ImportanceIncreases in vitamin D metabolites as well as increases in CRP concentrations were observed in racing sled dogs. This finding was contrary to the hypothesis that decreases in vitamin D status in athletes may be related to the acute phase inflammatory response during exercise. In addition, the increased 24,25(OH)D3 concentrations compared to what is observed in other species suggests metabolic variations in dogs that lead to enhanced disposal of vitamin D. |
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| Keywords: | Endocrinology Metabolism Nutrition Physiology Sports medicine Vitamins and minerals |
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