| 靶向蜕皮激素受体的新型4,5,6,7-四氢-2H-吲唑酰肼类衍生物的设计、合成及杀虫活性 |
| |
| 引用本文： | 郭兵博,蒋标标,董雅雯,金小宇,崔丽,张莉,杨新玲.靶向蜕皮激素受体的新型4,5,6,7-四氢-2H-吲唑酰肼类衍生物的设计、合成及杀虫活性[J].农药学学报,2022,24(1):39-48. |
| |
| 作者姓名： | 郭兵博 蒋标标 董雅雯 金小宇 崔丽 张莉 杨新玲 |
| |
| 作者单位： | 1.中国农业大学 理学院 应用化学系 农药创新研究中心，北京 100193 |
| |
| 基金项目： | 国家自然科学基金(21977114)；国家重点研发计划项目(2017YFD0200504). |
| |
| 摘 要： | 为了发现结构新颖的昆虫生长调节剂,以蜕皮激素受体(EcR)为靶标,以课题组发现的高活性化合物C(N-(4-(叔丁基)苯基)-2-苯基-2,4,5,6,7,8-六氢环庚基C]吡唑-3-甲酰胺)为先导化合物,利用活性亚结构拼接的方法,设计合成了25个未见文献报道的新型4,5,6,7-四氢-2H-吲唑酰肼类衍生物,其结构经...
|
| 关 键 词： | 蜕皮激素受体 昆虫生长调节剂 4 5 6 7-四氢-2H-吲唑酰肼衍生物 合成 杀虫活性 蛋白结合活性 |
| 收稿时间： | 2021-08-12 |
Design,synthesis and insecticidal activity of novel 4,5,6,7-tetrahydro-2H-indazole hydrazide derivatives targeting ecdysone receptor |
| |
| GUO Bingbo,JIANG Biaobiao,DONG Yawen,JIN Xiaoyu,CUI Li,ZHANG Li,YANG Xinling.Design,synthesis and insecticidal activity of novel 4,5,6,7-tetrahydro-2H-indazole hydrazide derivatives targeting ecdysone receptor[J].Chinese Journal of Pesticide Science,2022,24(1):39-48. |
| |
| Authors: | GUO Bingbo JIANG Biaobiao DONG Yawen JIN Xiaoyu CUI Li ZHANG Li YANG Xinling |
| |
| Affiliation: | 1.Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China2.Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China |
| |
| Abstract: | In order to discover insect growth regulators with new structures, 25 novel 4,5,6,7-tetrahydro-2H-indazole hydrazide derivatives were designed and synthesized by the method of linking active substructures with the lead compound C based on the ecdysone receptor (EcR). The structures of these target compounds were confirmed by 1H NMR, 13C NMR and HRMS. Moreover, molecular docking study revealed that all target compounds had a good binding force with the EcR , wherein the compound I-15 had the similar binding mode with EcR as tebufenozide, which can bind well with the active site of EcR. And the protein binding experiments showed that the binding activity of I-15 to EcR was 75.8%±7.2% at a concentration of 40 mg/L. In addition, preliminary bioassay results showed that some target compounds had certain insecticidal activity against the Plutella xylostella at 500 mg/L, but their activities were not as good as tebufenozide and C . The ClogP values of target compounds were lower than the lead compound, which indicated that their liposolubility was not good enough to penetrate the insect cuticle, resulting in poor insecticidal activity. This work provides important clues for the further structure optimization. |
| |
| Keywords: | |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《农药学学报》浏览原始摘要信息 |
|
点击此处可从《农药学学报》下载全文 |
|
