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Pharmacokinetics of meloxicam in mature swine after intravenous and oral administration |
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| Authors: | M D Pairis‐Garcia A K Johnson B KuKanich L Wulf S T Millman K J Stalder L A Karriker J F Coetzee |
| Affiliation: | 1. Department of Animal Science, Iowa State University, Ames, IA, USA;2. Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA;3. Pharmacology Analytical Support Team (PhAST), College of Veterinary Medicine, Iowa State University, Ames, IA, USA;4. Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA, USA;5. Swine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA, USA |
| Abstract: | The purpose of this study was to compare the pharmacokinetics of meloxicam in mature swine after intravenous (i.v.) and oral (p.o.) administration. Six mature sows (mean bodyweight ± standard deviation = 217.3 ± 65.68 kg) were administered an i.v. or p.o. dose of meloxicam at a target dose of 0.5 mg/kg in a cross‐over design. Plasma samples collected up to 48 h postadministration were analyzed by high‐pressure liquid chromatography and mass spectrometry (HPLC‐MS) followed by noncompartmental pharmacokinetic analysis. Mean peak plasma concentration (CMAX) after p.o. administration was 1070 ng/mL (645–1749 ng/mL). TMAX was recorded at 2.40 h (0.50–12.00 h) after p.o. administration. Half‐life (T½ λz) for i.v. and p.o. administration was 6.15 h (4.39–7.79 h) and 6.83 h (5.18–9.63 h), respectively. The bioavailability (F) for p.o. administration was 87% (39–351%). The results of this study suggest that meloxicam is well absorbed after oral administration. |
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