[1] 陈立平,赵平,任广旭,等.乳铁蛋白的研究现状与进展[J].农产品加工,2019,8:68-70. CHEN L P,ZHAO P,REN G X,et al.Research status and progress of lactoferrin[J].Farm Products Processing,2019,8:68-70.(in Chinese) [2] 陈镜羽,单毓娟,杜明,等.乳铁蛋白对铁代谢的影响及其在神经退行性疾病中的应用[J].现代生物医学进展,2013,13(3):564-566. CHEN J Y,SHAN Y J,DU M,et al.Effect of lactoferrin on iron metabolism and the application in neurodegenerative diseases[J].Progress in Modern Biomedicine,2013,13(3):564-566.(in Chinese) [3] 肖奕昕,赵善仓,董燕婕,等.乳铁蛋白生物学功能及其检测方法研究进展[J].中国乳品工业,2018,46(3):29-34. XIAO Y X,ZHAO S C,DONG Y J,et al.Advances in biological functions and determination methods of lactoferrin[J].China Dairy Industry,2018,46(3):29-34.(in Chinese) [4] 郝丽媛,孙鹏,卜登攀,等.乳铁蛋白检测及应用研究进展[J].中国畜牧杂志,2016,52(1):82-86. HAO L Y,SUN P,BU D P,et al.Rearch advances in detection and application of lactoferrin[J].Chinese Journal of Animal Science,2016,52(1):82-86.(in Chinese) [5] LAFFAN A M,MCKENZIE R,FORTI J,et al.Lactoferrin for the prevention of post-antibiotic diarrhoea[J].Journal Health Papulation and Nutrition,2011,29:547-551. [6] 徐拔群,李志飞,杨齐华,等.乳铁蛋白联合三联疗法治疗小儿幽门螺杆菌相关性胃病的疗效及安全性评价[J].中华全科医学,2018,16(4):583-585. XU B Q,LI Z F,YAMG Q H,et al.Efficacy and safety of lactoferrin combined with triple therapy in the treatment of Helicobacter pylori-associated gastropathy in children[J].Chinese General Practice,2018,16(4):583-585.(in Chinese) [7] TSUDA H,KOZU T,LINUMA G,et al.Cancer prevention by bovine lactoferrin:From animal studies to human trial[J].Biometals,2010,23(3):399-409. [8] 庞广昌,胡志和,陈庆森.乳铁蛋白的抗病毒活性[J].食品科学,2006,1:253-257. PANG G C,HU Z H,CHEN Q S.Antiviral activity of lactoferrin[J]. Food Science,2006,1:253-257.(in Chinese) [9] ANDERSEN J H,OSBAKK S A,VORLAND L H,et al.Lactoferrin and cyclic lactoferricin inhibit the entry of human cytomegalovirus into human fibroblasts[J].Antiviral Research,2001,51(2):141-149. [10] MURPHY M E,KARIWA H,MIZUTANT T,et al.Characterization of in vitro and in vivo antiviral activity of lactoferrin and ribavirin upon hantavirus[J].The Journal of Veterinary Medical Science,2001,63(6):637-645. [11] 王雷,蔡研,孙宏晨.重组人乳铁蛋白对口腔癌细胞周期及周期因子表达影响的实验研究[J].口腔医学研究,2010,1:19-21. WANG L,CAI Y,SUN H C.Experimental study on the effect of recombinant human lactoferrin on cell cycle and expression of cyclin in oral cancer cells[J].Stomatological Research,2010,1:19-21.(in Chinese) [12] LI H Y,LI P,YANG H G,et al.Investigation and comparison of the anti-tumor activities of lactoferrin,α-lactalbumin,and β-lactoglobulin in A549,HT29,HepG2,and MDA231-LM2 tumor models[J].Journal of Dairy Science,2019,102(11):9586-9597. [13] LI H,LI M,LUO C,et al.Lactoferrin exerts anti-tumor effects by inhibiting angiogenesis in a HT29 human colon tumor model[J].Journal of Agricul-tural & Food Chemistry,2017,65(48):10464-10472. [14] 高远,杨丽杰,马满玲,等.乳铁蛋白的免疫调节作用研究进展[J].中国药房,2014,25(37):3523-3525. GAO Y,YANG L J,MA M L,et al.Progress in immunomodulatory effect of lactoferrin[J].Chinese Pharmacy,2014,25(37):3523-3525.(in Chinese) [15] 孙瑞英,曲书强.补充乳铁蛋白对新生儿和婴幼儿影响的研究进展[J].中国儿童保健杂志,2019,27(2):168-170. SUN R Y,QU S Q.Research progress on the effects of lactoferrin supplement at action on new borns and infants[J].Chinese Journal of Child Health, 2019,27(2):168-170.(in Chinese) [16] TOMITA M,WAKABAYASHI H,SHIN K,et al.Twenty-five years of research on bovine lactoferrin applications[J].Biochimie,2009,91(1):52-57. [17] 陈文亮,苏米亚,贾宏信,等.α-乳白蛋白的功能特性及其在婴儿配方乳粉中的应用[J].乳业科学与技术,2019,42(1):33-38. CHEN W L,SU M Y,JIA H X,et al.Functional characteristics and application in infant formula of alpha-lactalbumin[J].Journal of Dairy Science and Technology,2019,42(1):33-38.(in Chinese) [18] 方冰,郭慧媛,张昊,等.乳白蛋白-油酸复合物抗癌活性研究进展[J].中国乳业,2011,8:36-38. FANG B,GUO H Y,ZHANG H,et al.Research progress of anticancer activity of lactalbumin oleic acid complex[J].China Dairy,2011,8:36-38.(in Chinese) [19] KOHLER C,GOGVADZE V,HÅKANSSON A,et al.A folding variant of human α-lactalbumin induces mitochondrial permeability transition in isolated mitochondria[J].European Journal of Biochemistry,2001,268:186-191. [20] 张明,方冰,张录达,等.牛α-乳白蛋白-亚油酸复合物的结构及抗肿瘤活性[J].光谱学与光谱分析,2015,35(9):2609-2612. ZHANG M,FANG B,ZHANG L D,et al.Structure and antitumor activity of bovine α-lactalbumin linoleic acid complex[J].Spectroscopy and Spectral Analysis,2015,35(9):2609-2612.(in Chinese) [21] PELLIGRINI A,THOMAS U,BRAMAZ N,et al.Isolation and identification of three bactericidal domains in the bovine α-lactalbumin molecule[J].Biochimica et Biophysica Acta,1999,1426(3):439-448. [22] SVENSSON M,HAKANSSON A,MOSSBERG A K,et al.Conversion of alpha-lactalbumin to a protein inducing apoptosis[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(8):4221-4226. [23] HAKANSSON A,SVENSSON M,MOSSBERG A K,et al.A folding variant of alpha-lactalbumin with bacteri-cidal activity against Streptococcus pneumonia[J].Molecular Microbiology,2000,35:589-600. [24] JEAN-CHRISTOPHE R,SÉBASTIEN B,MARIE-JOSÉ B,et al.An α-lactalbumin-enriched and symbiotic-supplemented v.a standard infant formula:A multicentre,double-blind,randomised trial[J].The British Journal of Nutrition,2011,107(11):1616-1622. [25] TRABULSI J,CAPEDING R,LEBUMFACIL J,et al.Effects of an alpha-lactalbumin-enriched infant formula with lower protein on growth[J].European Journal of Clinical Nutrition,2011,65(2):167-174. [26] LIEN E L,DAVIS A M,EULER A R.Growth and safety in term infants fed reduced-protein formula with added bovine alpha-lactalbumin[J].Journal of Pediatric Gastroenterology and Nutrition,2004,38(2):170-176. [27] 李梦寒,王志勇,盛雪,等.基于16S rRNA技术分析α-乳白蛋白对大鼠肠道菌群的影响[J].食品科学,2020,41(6):155-162. LI M H,WANG Z Y,SHENG X,et al.Effect of α-lactalbumin on intestinal flora in rats analyzed by 16S rRNA high-throughput sequencing[J].Food Science, 2020,41(6):155-162.(in Chinese) [28] 吴相迭,宋馨然,刘斯,等.α-乳白蛋白酶解物体外抗氧化及活性氧清除作用[J].中国乳品工业,2018,46(1):4-7. WU X D,SONG X R,LIU S,et al.Antioxidant and ROS scavenging activity of α-lactalbumin hydrolysates against oxidative stress in HepG2 cells[J].China Dairy Industry,2018,46(1):4-7.(in Chinese) [29] 李燕,伊洋,石径,等.低致敏牛乳清蛋白的酶法制备[J].乳业科学与技术,2019,42(5):4-8. LI Y,YI Y,SHI J,et al.Enzymatic preparation of bovine whey protein hydrolysate with low allergenicity[J].Dairy Science and Technology, 2019,42(5):4-8.(in Chinese) [30] KUSHIBIKI S,HODATE K,KURISAKI J,et al.Effect of β-lactoglobulin on plasma retinol and triglyceride concentrations,and fatty acid composition in calves[J].Journal of Dairy Research,2001,68(4):579-586. [31] VERMEIRSSEN V J C,VAN CAMP J,AUGUSTIJNS P,et al.ACE inhibitory activity from pea and whey protein:In vitro gastrointestinal digestion and transport in caco-2 model[J].Journal of Food Protection,2002,63(11):1503-1510. [32] NAGAOKA S,FUTAMURA Y,MIWA K,et al.Identification of novel hypocholesterolemic peptides derived from bovine milk beta-lactoglobulin[J].Biochemical and Biophysical Research Communications,2001,281(1):11-17. [33] 高学飞,王志耕.β-乳球蛋白应用研究进展[J].乳品加工,2005,7(7):41-44. GAO X F,WANG Z G.Research progress of β-lactalbumin application[J].Dairy Industry,2005,7(7):41-44.(in Chinese) [34] KOKUBA H,AURELIAN L,NEURATH A R.3-hydroxyphthaloyl beta-lactoglobulin.IV Antiviral activity in the mouse model of genital herpesvirus infection[J].Antiviral Chemistry,1998,9(4):353-357. [35] 师文文,吕攀,徐庆强,等.油酸在黄曲霉毒素诱导肝细胞损伤中的保护作用[J].中国油料作物学报,2019,41(2):267-274. SHI W W,LYU P,XU Q Q,et al.Protective effect of oleic acid on aflatoxin-induced hepatocyte injury[J].Chinese Journal of Oil Crop Sciences,2019,41(2):267-274.(in Chinese) [36] PSALTOPOULOU T,KOSTI R I,HAIDOPOULOS D,et al.Olive oil intake is inversely related to cancer prevalence:A systematic review and a meta-analysis of 13,800 patients and 23,340 controls in 19 observa-tional studies[J].Lipids in Health and Disease,2011,10:127. [37] JUNPING W,TAKAYAMA K,NAGAI T,et al.Pharmacokinetics and antitumor effects of vincristine carried by microemulsions composed of PEG-lipid,oleic acid,vitamin E and cholesterol[J].International Journal of Pharmaceutics,2003,251:13-21. [38] 董丽红,张瑞芬,黄菲,等.油酸诱导单纯性肝脂肪变性细胞模型的建立及应用[J].中国药理学通报,2017,33(11):1622-1626. DONG L H,ZHANG R F,HUANG F,et al.Study of two kinds of Alzheimer's disease tree shrew models[J].Chinese Pharmacological Bulletin,2017,33(11):1622-1626.(in Chinese) [39] 魏刚,孙刚,乔宁,等. 改性油酸吸附处理含铜离子废水[J].北京化工大学学报(自然科学版),2010,37(2):113-116. WEI G,SUN G,QIAO N,et al.Trement of cupricwaste water by a new liquid sorbent modified oleic acid[J].Journal of Beijing University of Chemical Technology (Natural Science Edition),2010,37(2):113-116.(in Chinese) [40] SATARUG S,VESEY D A,GOBE G C.Kidney cadmium toxicity,diabetes and high blood pressure:The perfect storm[J].Tohoku Journal of Experi-mental Medicine,2017,241(1):65-87. [41] 张鼎. 镉中毒及锌对镉中毒的作用机理研究[D].武汉:华中农业大学,2015. ZHANG D.Study on the mechanism of cadmium poisoning and the effect of zinc on cadmium poisoning[D].Wuhan:Huazhong Agricultural Univer-sity,2015.(in Chinese) [42] 徐敏. 小鼠镉的蓄积性毒性试验及残留分析研究[D].雅安:四川农业大学,2009. XU M.Cumulative toxicity test and residue analysis of cadmium in mice[D].Ya'an:Sichuan Agricultural University,2009.(in Chinese) [43] 金媛媛,周蓉,匡兴亚. 镉致肾损伤机制的研究进展[J].环境与职业医学,2018,35(2):180-184. JIN Y Y,ZHOU R,KUANG X Y.Research progress on renal injury induced by cadmium[J].Journal Environment Occupational Medicine,2018,35(2):180-184.(in Chinese) [44] 王海萍. 硝基油酸对急慢性肾损伤保护作用及机制的研究[D].济南:山东大学,2010. WANG H P.Study on the protective effect and mechanism of nitrooleic acid on acute and chronic renal injury[D].Jinan:Shandong University,2010.(in Chinese) [45] 吴涛,关广聚,刘海英. 硝基油酸对肾急性缺血再灌注模型小鼠肾的保护作用及其机制[J].中国药理学与毒理学杂志,2013,27(5):776-782. WU T,GUAN G J,LIU H Y.The protective effect of nitrooleic acid on the kidney of acute renal ischemia-reperfusion model mice and its mechanism[J].Chinese Journal of Pharmacology and Toxicology,2013,27(5):776-782.(in Chinese) [46] OBIOHA F C,EZENDUKA E,UKOHA J C,et al. Assessment of cadmium (Cd) residues in organs and muscles of slaughtered pigs at Nsukka and environs in Enugu State,Nigeria[J].Journal of Veterinary Medicine and Animal Health,2016,8(11):199-206. [47] 翟齐啸.乳酸菌减除镉危害的作用及机制研究[D].无锡:江南大学,2015. ZHAI Q X.Study on the role and mechanism of lactic acid bacteria in reducing cadmium damage[D].Wuxi:Jiangnan University,2015.(in Chinese) [48] 王靖雯,陈泽娜,高健,等.油酸对小鼠急性镉中毒的缓解作用及镉残留的影响[J].生物学杂志,2019,36(4):50-54. WANG J W,CHEN Z N,GAO J,et al.The alleviative effect of oleic acid on acute cadmium poisoning in mice and the effect of cadmium residue[J].Journal of Biology,2019,36(4):50-54.(in Chinese) [49] 王菲,佘星星,孙冰洁,等.螺旋藻γ-亚麻酸的提取优化及体外抗氧化活性的研究[J].食品工业科技,2014,35(19):68-72. WANG F,SHE X X,SUN B J,et al.Study on the optimized extraction and in vitro antioxidant activities of γ-linolenic acid from Spirulina plantensis[J].Science and Technology of Food Industry,2014,35(19):68-72.(in Chinese) [50] 赵要武,付娟,周绍良,等.α-亚麻酸对高糖下人红细胞抗氧化系统和膜的影响[J].江苏预防医学,2013,24(2):1-4. ZHAO Y W,FU J,ZHOU S L,et al.Effect of α-linolenic acid on antioxidant system and membrane of human erythrocytes under high glucose[J].Jiangsu Preventive Medicine,2013,24(2):1-4.(in Chinese) [51] DAVID E M,MAUREEN R S.Gamma linolenic acid attenuates cardiovascuar responses to stress in borderline hypertensive rats[J].Lipids,1985,20(9):573-577. [52] DEFERNE J L,LEEDS A R.The antihypertensive effect of dietary supplementation with a 6-desaturated essential fatty acid concentrate as compared with sunflower seed oil[J].Journal of Human Hyperten-sion,1992,6(2):113-119. [53] 殷俊俊,马传国,朱换,等.γ-亚麻酸降血压作用及其机制探究[J].粮食与油脂,2013,26(7):49-52. YIN J J,MA C G,ZHU H,et al.The hypotensive effect of gamma linolenic acid and its mechanisms[J].Food and Oil,2013,26(7):49-52.(in Chinese) [54] 赵宝琴,邹慧,姜文月,等.亚麻酸磷脂软胶囊降血脂药理作用[J].安徽农业科学,2015,43(23):3-5. ZHAO B Q,ZOU H,JIANG W Y,et al.Study on pharmacological effect of flax acid phospholipid soft capsules lowering blood lipid[J].Journal of Anhui Agricultural Science,2015,43(23):3-5.(in Chinese) [55] 马润娣,于立坚,西村实,等.γ-亚麻酸的抗癌活性[J].营养学报,1993,4:390-396. MA R D,YU L J,XI C S,et al.Antitumor activity of γ-linolenic acid[J].Journal of Nutrition,1993,4:390-396.(in Chinese) [56] 卜云萍,王光风,陈竺.转基因高γ-亚麻酸大豆油抗肿瘤作用的研究[J].中国生物工程杂志,2005,25(7):92-97. BU Y P,WANG G F,CHEN Z.Antitumor of the transgenic soybean oil[J].Chinese Bioengineering,2005,25(7):92-97.(in Chinese) [57] 王彦武,赵鹏,刘荣珍,等.α-亚麻酸减肥功能的实验研究[J].中国热带医学,2005,4:863-864. WANG Y W,ZHAO P,LIU R Z,et al.Experimental study on the effect of α-linolenic acid on weight control[J].Chinese Tropical Medicine,2005,4:863-864.(in Chinese) [58] FORSYTH J S,CARLSON S.Long-chain polyunsaturated fatty acids in infant nutrition:Effects on infant development[J].Current Opinion in Clinical Nutrition and Metabolic Care,2001,4:123-126. [59] FEWTRELL M S,MORLEY R,ABBOTT R A,et al.Double blind,randomized trial of long chain polyunsaturated fatty acid supplementation in formula fed to preterm infants[J].Pediatric,2002,110(1):73-82. [60] 刘敬.DHA与婴幼儿智力和视力发育[J].中华现代儿科学杂志,2005,2(5):414-416. LIU J.DHA and infant intelligence and vision development[J].Chinese Journal of Modern Pediatrics,2005,2(5):414-416.(in Chinese) [61] SMUTS C M,HUANG M,MUNDY D,et al.A randomized trial of docosahexaenoic acid supplementation during the third trimester of pregnancy[J]. American Journal of Obstetrics and Gynecology,2003,101(3):469-479. [62] 陆姝欢,汪志明,李博玲,等.DHA对婴幼儿智力发育的有益效果[J].中国乳品工业,2014,42(11):39-41. LU S H,WANG Z M,LI B L,et al.Beneficial effect of docosahexaenoic acid on mental development of infants[J].Dairy Industry,2014,42(11):39-41.(in Chinese) [63] KURATKO C N,BARRETT E C,NELSON E B,et al.The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children:A review[J].Nutrients,2013,5:2777-2810. [64] LAVIE C J,MILANI R V,MEHRA M R,et al.Omega-3 fatty acids and cardiovascular disease[J].Journal of the American College of Cardiology,2009,54(7):585-594. [65] 周鸿,山杉公男.DHA对大白鼠血胆固醇浓度及磷脂分子组成的影响[J].江西科学,2003,2:27-32. ZHOU H,SU G Y M.Effect of dietary docosahexaenoic ACID on plasma cholesterol concentrations and lipid molecular species in rats[J].Jiangxi Science,2003,2:27-32.(in Chinese) [66] 冯宪光,姚文环.DHA复合物抗肿瘤作用的实验研究[J].预防医学论坛,2009,5:567-569. FENG X G,YAO W H.Experimental study on antitumor effect of DHA complex[J].Preventive Medicine Tribune,2009,5:567-569.(in Chinese) [67] 褚遵华,程东,韩晓英.DHA复合物诱导人胃癌细胞SGC-7901凋亡的实验研究[J].预防医学论坛,2011,17(11):1016-1017. CHU Z H,CHENG D,HAN X Y.Study on DHA compound inducing apoptosis of human gastric carcinoma SGC-7901[J].Preventive Medicine Tribune,2011,17(11):1016-1017.(in Chinese) [68] 杨贤庆,吕军伟,林婉玲,等.DHA功能特性以及抗氧化性研究进展[J].食品工业科技,2014,35(2):390-394. YANG X Q,LYU J W,LIN W L,et al.Research progress in biological function and antioxidative activity of DHA[J].Science and Technology of Food Industry,2014,35(2):390-394.(in Chinese) [69] 黄菊华,李蕴成.DHA的功能及在食品添加中的应用研究[J].中国食物与营养,2014,20(4):76-79. HUANG J H,LI Y C.Functions of DHA and its application in food addictives[J].Food and Nutrition in China,2014,20(4):76-79.(in Chinese) [70] 何天博,姜玲玲.DHA抑制2型糖尿病大鼠肝脏炎症改善胰岛素抵抗的机制研究[A].生物化学与分子生物学会论文集[C].2013. HE T B,JIANG L L.Mechanism of DHA inhibiting liver inflammation and improving insulin resistance in type 2 diabetic rats[A].Proceedings of Biochemistry and Molecular Biology Society[C].2013.(in Chinese) |