It is an effective way to improve grain yield and plant biomass by exploring the optimal drip irrigation and fertilization program for sandy spring maize(Zea mays L.).In this paper，the effects of different formula fertilization of nitrogen，phosphorus and potassium on grain yield and quality of maize dry matter in jointing，tasseling and harvesting periods were investigated by using three-factor D-saturated optimal design.The results showed that(1)the grain yield was increased by 32.60% to 52.90% with different formula fertilization of nitrogen，phosphorus and potassium.The analysis of yield equation and interaction between two factors showed that combined nitrogen，phosphorus and potassium could improve the grain yield effectively，and that the effect of nitrogen was the most obvious，followed by potassium and phosphorus，and that the grain yield increased first and then decreased with the increase of applying fertilization.(2)The effect of nitrogen，phosphorus and potassium on plant biomass and harvest index was significant.The treatments with the highest dry matter quality and the highest harvest index were formula fertilization of nitrogen，phosphorus and potassium in the three growth stages.(3)According to the analysis of maize yield and plant biomass in different growth stages in the condition of drip irrigation under mulching film，the most optimal formula fertilization is nitrogen fertilizer 240 kg·hm-2，phosphorus fertilizer 80 kg·hm-2 and potassium fertilizer 225 kg·hm-2 in sandy land.