副溶血性弧菌Ⅲ型分泌系统与Ⅵ型分泌系统的研究进展
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Q 932

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国家自然科学基金面上项目(31671779,31972188);国家重点研发计划(2018YFC1602205);上海市科学技术委员会上海市“科技创新行动计划”农业领域项目(19391901600);上海市科技兴农项目(沪农科推字〔2017〕第4-4号);上海市教育委员会科研创新计划 (2017-01-07-00-10-E00056)


Progress in the research of type Ⅲ secretion system and type Ⅵ secretion system of Vibrio parahaemolyticus
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    摘要:

    副溶血性弧菌(Vibrio parahaemolyticus,VP)是一种常见的革兰氏阴性细菌,主要分布在海洋、海口和河口沉积物中,能够引起人急性肠胃炎、伤口感染和败血症,同时危害水产品养殖业。由该菌引起的食物中毒事件在全世界范围内频繁发生,该菌被认为是微生物性食物中毒的主要病原菌之一。影响副溶血性弧菌致病性的毒力因素包括溶血素、黏附因子、分泌系统等,尤其在分泌系统中,Ⅲ型分泌系统(Type Ⅲ secretion systems,T3SS)和Ⅵ型分泌系统(T6SS)与副溶血性弧菌致病性密切相关。T3SS是一种多亚基针状结构,将分泌蛋白通过供体细胞质直接注入受体细胞质;T6SS是一种接触依赖性蛋白分泌装置,将毒素直接注入目标细胞内。通过对Ⅲ型分泌系统和Ⅵ型分泌系统的研究进展进行梳理,从这两种分泌系统的结构出发,并对其功能和调控机制分别进行分析比较,指出了二者在效应蛋白及产生毒素上的不同,找出了二者与副溶血性弧菌定植的关系,以期通过这两者的联系进而深入了解副溶血性弧菌的致病机制,为防治该菌提供科学指导。

    Abstract:

    Vibrio parahaemolyticus(VP) is a common gram-negative bacterium, mainly distributed in marine, estuary and estuarine sediments, which can cause acute gastroenteritis, wound infection and sepsis in humans, and endanger aquatic product aquaculture. Food poisoning incidents caused by this bacterium occur frequently all over the world, and this bacterium is considered to be one of the main pathogens of microbial food poisoning. The virulence factors that affect the pathogenicity of VP include hemolysin, adhesion factor, secretion system, etc., especially in the secretion systems, Type Ⅲ Secretion Systems (T3SS) and Type Ⅵ Secretion Systems (T6SS). It is closely related to the pathogenicity of VP. T3SS is a multi-subunit needle-like structure that injects secreted proteins directly into the recipient cytoplasm through the donor cytoplasm; T6SS is a contact-dependent protein secretion apparatus that injects toxins directly into target cells. By sorting out the research progress of T3SS and T6SS, starting from the structure of these two secretion systems, and analyzing and comparing their functions and regulatory mechanisms, it was pointed out that the two are involved in effector proteins and regulatory mechanisms. The difference in the production of toxins, the relationship between the two and the colonization of VP were found out, in order to further understand the pathogenic mechanism of VP through the connection between the two, and provide scientific guidance for the prevention and treatment of the bacteria.

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刘海泉,江春铃,赵伟,钱江,潘迎捷,胡金庆,赵勇.副溶血性弧菌Ⅲ型分泌系统与Ⅵ型分泌系统的研究进展[J].上海海洋大学学报,2023,32(3):660-668.
LIU Haiquan, JIANG Chunling, ZHAO Wei, QIAN Jiang, PAN Yingjie, HU Jinqing, ZHAO Yong. Progress in the research of type Ⅲ secretion system and type Ⅵ secretion system of Vibrio parahaemolyticus[J]. Journal of Shanghai Ocean University,2023,32(3):660-668.

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  • 收稿日期:2022-02-22
  • 最后修改日期:2022-08-25
  • 录用日期:2022-08-26
  • 在线发布日期: 2023-06-17
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